Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT11 Gene

Aliases for WNT11 Gene

  • Wnt Family Member 11 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 11 2 3
  • Protein Wnt-11 3
  • HWNT11 3

External Ids for WNT11 Gene

Previous GeneCards Identifiers for WNT11 Gene

  • GC11M078224
  • GC11M077436
  • GC11M076120
  • GC11M075623
  • GC11M075575
  • GC11M075897
  • GC11M072194

Summaries for WNT11 Gene

Entrez Gene Summary for WNT11 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT11 Gene

WNT11 (Wnt Family Member 11) is a Protein Coding gene. Diseases associated with WNT11 include Mass Syndrome. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and transcription regulatory region DNA binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT11 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Gene Wiki entry for WNT11 Gene

Additional gene information for WNT11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT11 Gene

Genomics for WNT11 Gene

GeneHancer (GH) Regulatory Elements for WNT11 Gene

Promoters and enhancers for WNT11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I076205 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 552.7 +5.8 5784 5.2 ARID4B SIN3A ZBTB7B YY1 ZNF213 ZNF143 SP3 SP5 REST SMARCB1 WNT11 GC11P076210 ENSG00000255362 ENSG00000261578 LOC101928837 ENSG00000254933
GH11I076233 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -21.4 -21396 4.3 HDGF PKNOX1 CLOCK ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 GC11M076236 PIR59119 TRP-AGG2-4 TRP-TGG2-1 EMSY RPS3 WNT11 GVQW3 SNORD15B ENSG00000272301
GH11I076152 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 +60.9 60864 2.3 HDGF ATF1 ARNT ARID4B ZNF2 BRCA1 ZNF48 YY1 CBX5 ARID2 ENSG00000254814 DGAT2 WNT11 EMSY MOGAT2 SNORD15B ENSG00000254429 ENSG00000255421 GC11P076191
GH11I076146 Enhancer 0.9 ENCODE dbSUPER 11.5 +65.8 65767 3.2 MXI1 FOXA2 ZNF792 SAP130 ZFP64 ARID4B THRB ZNF48 ZNF316 TRIM24 WNT11 DGAT2 ENSG00000254814 MOGAT2 UVRAG LOC100506113 ENSG00000255421 GC11P076191
GH11I076329 Enhancer 0.8 ENCODE 11.8 -115.3 -115264 0.2 FOXA2 ARID4B RARA ETS1 THAP11 HMG20B CEBPB ELF1 NR2F2 KAT8 WNT11 LOC105369395 THAP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNT11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT11 gene promoter:

Genomic Locations for WNT11 Gene

Genomic Locations for WNT11 Gene
chr11:76,186,325-76,214,008
(GRCh38/hg38)
Size:
27,684 bases
Orientation:
Minus strand
chr11:75,897,369-75,921,780
(GRCh37/hg19)

Genomic View for WNT11 Gene

Genes around WNT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT11 Gene

Proteins for WNT11 Gene

  • Protein details for WNT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96014-WNT11_HUMAN
    Recommended name:
    Protein Wnt-11
    Protein Accession:
    O96014
    Secondary Accessions:
    • B2R8Z6
    • Q14DE8
    • Q8WZ98

    Protein attributes for WNT11 Gene

    Size:
    354 amino acids
    Molecular mass:
    39179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT11 Gene

Post-translational modifications for WNT11 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at isoforms=40, posLast=9090, posLast=160160, posLast=300300, and isoforms=304

No data available for DME Specific Peptides for WNT11 Gene

Domains & Families for WNT11 Gene

Gene Families for WNT11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WNT11 Gene

Suggested Antigen Peptide Sequences for WNT11 Gene

Graphical View of Domain Structure for InterPro Entry

O96014

UniProtKB/Swiss-Prot:

WNT11_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT11: view

Function for WNT11 Gene

Molecular function for WNT11 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 11,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development,expressed in the perichondrium of the developing skeleton
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Phenotypes From GWAS Catalog for WNT11 Gene

Gene Ontology (GO) - Molecular Function for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 20103596
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding NAS 24431302
GO:0005515 protein binding IPI 25416956
GO:0030295 protein kinase activator activity IMP 20103596
genes like me logo Genes that share ontologies with WNT11: view
genes like me logo Genes that share phenotypes with WNT11: view

Animal Models for WNT11 Gene

MGI Knock Outs for WNT11:

Animal Model Products

miRNA for WNT11 Gene

Clone Products

  • Addgene plasmids for WNT11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT11 Gene

Localization for WNT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT11 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 20103596
genes like me logo Genes that share ontologies with WNT11: view

Pathways & Interactions for WNT11 Gene

genes like me logo Genes that share pathways with WNT11: view

SIGNOR curated interactions for WNT11 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001822 kidney development IEA --
GO:0001837 epithelial to mesenchymal transition IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0003402 planar cell polarity pathway involved in axis elongation IEA --
genes like me logo Genes that share ontologies with WNT11: view

Drugs & Compounds for WNT11 Gene

(2) Drugs for WNT11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with WNT11: view

Transcripts for WNT11 Gene

Unigene Clusters for WNT11 Gene

Wingless-type MMTV integration site family, member 11:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT11

Alternative Splicing Database (ASD) splice patterns (SP) for WNT11 Gene

No ASD Table

Relevant External Links for WNT11 Gene

GeneLoc Exon Structure for
WNT11
ECgene alternative splicing isoforms for
WNT11

Expression for WNT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT11 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.5) and Adipose - Subcutaneous (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT11 Gene



Protein tissue co-expression partners for WNT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WNT11 Gene:

WNT11

SOURCE GeneReport for Unigene cluster for WNT11 Gene:

Hs.108219

mRNA Expression by UniProt/SwissProt for WNT11 Gene:

O96014-WNT11_HUMAN
Tissue specificity: Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.

Evidence on tissue expression from TISSUES for WNT11 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with WNT11: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT11 Gene

Orthologs for WNT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WNT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT11 33 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia WNT11 33 34
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia WNT11 33 34
  • 94.16 (n)
mouse
(Mus musculus)
Mammalia Wnt11 33 16 34
  • 92.37 (n)
rat
(Rattus norvegicus)
Mammalia Wnt11 33
  • 92 (n)
oppossum
(Monodelphis domestica)
Mammalia WNT11 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT11 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT11 33 34
  • 77.68 (n)
lizard
(Anolis carolinensis)
Reptilia WNT11 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt11r 33
  • 74.78 (n)
Str.3082 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1073 33
zebrafish
(Danio rerio)
Actinopterygii wnt11r 33 34
  • 73.14 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8886 33
Species where no ortholog for WNT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WNT11 Gene

ENSEMBL:
Gene Tree for WNT11 (if available)
TreeFam:
Gene Tree for WNT11 (if available)

Paralogs for WNT11 Gene

Paralogs for WNT11 Gene

(17) SIMAP similar genes for WNT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT11: view

Variants for WNT11 Gene

Sequence variations from dbSNP and Humsavar for WNT11 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs758816226 uncertain-significance, Exstrophy of the bladder 76,187,183(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000134848 -- 76,188,774(-) G/C intron_variant
rs1000315104 -- 76,204,886(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000371662 -- 76,199,491(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000385923 -- 76,194,299(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT11 Gene

Variant ID Type Subtype PubMed ID
nsv951044 CNV deletion 24416366
nsv555446 CNV loss 21841781
nsv1053129 CNV gain 25217958
nsv1044943 CNV gain 25217958
nsv1037940 CNV gain 25217958
esv3626864 CNV gain 21293372
dgv1227n100 CNV gain 25217958
dgv1226n100 CNV gain 25217958

Variation tolerance for WNT11 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT11 Gene

Human Gene Mutation Database (HGMD)
WNT11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT11 Gene

Disorders for WNT11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WNT11 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
mass syndrome
  • mass phenotype
- elite association - COSMIC cancer census association via MalaCards
Search WNT11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNT11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT11 Gene

Publications for WNT11 Gene

  1. Molecular cloning and characterization of human WNT11. (PMID: 11712081) Kirikoshi H … Katoh M (International journal of molecular medicine 2001) 3 4 22 58
  2. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. (PMID: 9757009) Lako M … Lindsay S (Gene 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PMID: 20890934) Menezes R … Vieira AR (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 44 58
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58

Products for WNT11 Gene

  • Addgene plasmids for WNT11

Sources for WNT11 Gene

Content
Loading form....