Free for academic non-profit institutions. Other users need a Commercial license
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
WNT10A (Wnt Family Member 10A) is a Protein Coding gene. Diseases associated with WNT10A include Schopf-Schulz-Passarge Syndrome and Odontoonychodermal Dysplasia. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT10B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005109 | frizzled binding | IBA | 21873635 |
GO:0005125 | cytokine activity | IBA | 21873635 |
GO:0048018 | receptor ligand activity | IDA | 28733458 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
2 | Gastric cancer |
.62
.62
|
|
3 | Aldosterone synthesis and secretion |
.41
|
.41
|
4 | mTOR signaling pathway (KEGG) |
.38
|
|
5 | Wnt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001942 | hair follicle development | IMP | 17847007 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0010628 | positive regulation of gene expression | IEA | -- |
GO:0014033 | neural crest cell differentiation | IEA | -- |
GO:0016055 | Wnt signaling pathway | IEA,TAS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | - | ||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WNT10A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | WNT10A 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WNT10A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Wnt10a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wnt10a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | WNT10A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | WNT10A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WNT10A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wnt10a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | wnt10a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Wnt10 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | egl-20 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
639357 | Pathogenic: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,298(+) | TC/T | FRAMESHIFT_VARIANT | |
642382 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,893,102(+) | G/T | MISSENSE_VARIANT | |
646775 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,161(+) | G/A | MISSENSE_VARIANT | |
654586 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,893,096(+) | G/T | MISSENSE_VARIANT | |
660265 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,363(+) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
schopf-schulz-passarge syndrome |
|
|
odontoonychodermal dysplasia |
|
|
tooth agenesis, selective, 4 |
|
|
hypohidrotic ectodermal dysplasia autosomal recessive |
|
|
tooth agenesis |
|
|