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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia an... See more...
Aliases for WNT10A Gene
Aliases for WNT10A Gene
External Ids for WNT10A Gene
- HGNC: 13829
- Entrez Gene: 80326
- Ensembl: ENSG00000135925
- OMIM: 606268
- UniProtKB: Q9GZT5
Previous GeneCards Identifiers for WNT10A Gene
- GC02P217761
- GC02P218466
- GC02P219709
- GC02P219947
- GC02P219570
- GC02P219453
- GC02P219745
- GC02P211599
Summaries for WNT10A Gene
-
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT10A Gene
WNT10A (Wnt Family Member 10A) is a Protein Coding gene. Diseases associated with WNT10A include Schopf-Schulz-Passarge Syndrome and Odontoonychodermal Dysplasia. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT10B.
UniProtKB/Swiss-Prot Summary for WNT10A Gene
-
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).
Additional gene information for WNT10A Gene
- HGNC(13829)
- Entrez Gene(80326)
- Ensembl(ENSG00000135925)
- OMIM(606268)
- UniProtKB(Q9GZT5)
- Open Targets Platform(ENSG00000135925)
- Monarch Initiative
- Search for WNT10A at DataMed
- Search for WNT10A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT10A Gene
Genomics for WNT10A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WNT10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WNT10A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT10A
- Top Transcription factor binding sites by QIAGEN in the WNT10A gene promoter:
-
- C/EBPalpha
- COMP1
- Lmo2
- MyoD
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for WNT10A Gene
Genomic Locations for WNT10A Gene
- chr2:218,874,116-218,899,581
- (GRCh38/hg38)
- Size:
- 25,466 bases
- Orientation:
- Plus strand
- chr2:219,745,085-219,764,303
- (GRCh37/hg19)
- Size:
- 19,219 bases
- Orientation:
- Plus strand
Genomic View for WNT10A Gene
Genes around WNT10A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
WNT10A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WNT10A Gene
Proteins for WNT10A Gene
-
Protein details for WNT10A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZT5-WN10A_HUMAN
- Recommended name:
- Protein Wnt-10a
- Protein Accession:
- Q9GZT5
- Q53S44
- Q96TA7
- Q9H7S8
Protein attributes for WNT10A Gene
- Size:
- 417 amino acids
- Molecular mass:
- 46444 Da
- Quaternary structure:
-
- Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).
Protein Expression for WNT10A Gene
Post-translational modifications for WNT10A Gene
- Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
-
Glycosylation at Asn106 and Asn363
- NX_Q9GZT5 (NX_Q9GZT5-1)
- Modification sites at PhosphoSitePlus
Other Protein References for WNT10A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Wnt10a Antibody
- Novus Biologicals Antibodies for WNT10A
-
Abcam antibodies for WNT10A
- Invitrogen Antibodies for WNT10A (AFLGC-WNT10A)
-
Biorbyt antibodies for WNT10A
-
Custom Antibody ServicesProSci Antibodies for WNT10A
-
Santa Cruz Biotechnology (SCBT) Antibodies for WNT10A
Protein Products
-
OriGene Purified Proteins for WNT10A
- Search Origene for MassSpec and Protein Over-expression Lysates for WNT10A
- Origene Custom Protein Services for WNT10A
Assay Products
No data available for DME Specific Peptides for WNT10A Gene
Domains & Families for WNT10A Gene
Gene Families for WNT10A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for WNT10A Gene
Suggested Antigen Peptide Sequences for WNT10A Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Wnt (Q05BQ6_HUMAN)
- Protein Wnt (Q53S44_HUMAN)
- Protein Wnt-10a (WN10A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9GZT5- Family:
-
- Belongs to the Wnt family.
Function for WNT10A Gene
Molecular function for WNT10A Gene
- UniProtKB/Swiss-Prot Function:
- Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).
LifeMap Function Summary for WNT10A Gene
During embryonic development, WNT10A as signaling molecule is secreted from the following cells
- Hair
It affects the following cells:
- Hair
Phenotypes From GWAS Catalog for WNT10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005109 | frizzled binding | IBA | 21873635 |
| GO:0005125 | cytokine activity | IBA | 21873635 |
| GO:0048018 | receptor ligand activity | IDA | 28733458 |
Phenotypes for WNT10A Gene
- MGI mutant phenotypes for WNT10A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for WNT10A:
Animal Models for WNT10A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNT10A - Select products 50% OFF >
- * WNT10A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WNT10A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNT10A
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT10A
miRNA for WNT10A Gene
- miRTarBase miRNAs that target WNT10A
-
- hsa-miR-130a-3p (MIRT053636)
- hsa-miR-1231 (MIRT533139)
- hsa-miR-203b-3p (MIRT533140)
- hsa-miR-27a-5p (MIRT533141)
- hsa-miR-3120-5p (MIRT533142)
- hsa-miR-378g (MIRT533143)
- hsa-miR-4486 (MIRT533144)
- hsa-miR-6860 (MIRT533145)
- hsa-miR-612 (MIRT533146)
- hsa-miR-5189-5p (MIRT533147)
- hsa-miR-3187-5p (MIRT533148)
- hsa-miR-1285-3p (MIRT533149)
- hsa-miR-4539 (MIRT533150)
- hsa-miR-361-3p (MIRT533151)
- hsa-miR-5685 (MIRT533152)
- hsa-miR-4690-3p (MIRT533153)
- hsa-miR-4724-5p (MIRT533154)
- hsa-miR-19b-3p (MIRT726097)
- hsa-miR-19a-3p (MIRT726098)
- hsa-miR-378a-3p (MIRT734708)
- rno-miR-378a-3p (MIRT734709)
- hsa-miR-2909 (MIRT790210)
- hsa-miR-3911 (MIRT790367)
- hsa-miR-4455 (MIRT790460)
- hsa-miR-6081 (MIRT790811)
- hsa-miR-6752-5p (MIRT790927)
- hsa-miR-7847-3p (MIRT791129)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WNT10A
- Browse OriGene Inhibitory RNA Products For WNT10A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT10A
Clone Products
- Applied Biological Materials (abm): Clones for WNT10A - Select products 50% OFF >
- * WNT10A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WNT10A
- Addgene plasmids for WNT10A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNT10A
Cell Line Products
-
Horizon Cell Lines for WNT10A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT10A Gene
Localization for WNT10A Gene
Subcellular locations from UniProtKB/Swiss-Prot for WNT10A Gene
- Secreted, extracellular space, extracellular matrix. Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT10A Gene
Pathways & Interactions for WNT10A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
.41
|
| 4 | mTOR signaling pathway (KEGG) |
.38
|
|
| 5 | Wnt signaling pathway | ||
Pathways by source for WNT10A Gene
2 Sino Biological pathways for WNT10A Gene
3 BioSystems pathways for WNT10A Gene
6 Reactome pathways for WNT10A Gene
14 KEGG pathways for WNT10A Gene
2 GeneGo (Thomson Reuters) pathways for WNT10A Gene
- Transcription Androgen Receptor nuclear signaling
- Translation Non-genomic (rapid) action of Androgen Receptor
2 R&D Systems pathways for WNT10A Gene
1 Tocris pathway for WNT10A Gene
7 Qiagen pathways for WNT10A Gene
- Colorectal Cancer Metastasis
- GSK3 Signaling
- Hedgehog Signaling in Mammals
- Human Embryonic Stem Cell Pluripotency
- Nanog in Mammalian ESC Pluripotency
2 GeneTex pathways for WNT10A Gene
Interacting Proteins for WNT10A Gene
GPS-Prot Interaction Network for WNT10A
SIGNOR curated interactions for WNT10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001942 | hair follicle development | IMP | 17847007 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0014033 | neural crest cell differentiation | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA,TAS | -- |
Transcripts for WNT10A Gene
mRNA/cDNA for WNT10A Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258411 2055 nts (view in UCSC)
- ENST00000458582 636 nts (view in UCSC)
- ENST00000483911 590 nts (view in UCSC)
- ENST00000489887 438 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNT10A - Select products 50% OFF >
- * WNT10A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WNT10A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNT10A
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT10A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WNT10A
- Browse OriGene Inhibitory RNA Products For WNT10A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT10A
Clone Products
- Applied Biological Materials (abm): Clones for WNT10A - Select products 50% OFF >
- * WNT10A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WNT10A
- Addgene plasmids for WNT10A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNT10A
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | - | ||||||||||
| SP3: |
Relevant External Links for WNT10A Gene
- GeneLoc Exon Structure for
- WNT10A
Expression for WNT10A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Dental Enamel
- Dental Papilla
-
Epithelial Cells
- Fetal Matrix Cells Hair Follicle
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Basal Cells Trachea
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Fetal Matrix Cells Hair Follicle
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Dermal Condensate Cells Dermal Papilla
-
Dermis (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
- Dental Papilla
-
Lung (Respiratory System)
- Basal Cells Trachea
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Limb (Muscoskeletal System)
- Ectoderm (Gastrulation Derivatives)
This gene is overexpressed in Peripheral blood mononuclear cells (44.4) and Pancreas (24.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT10A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT10A
SOURCE GeneReport for Unigene cluster for WNT10A Gene:
Hs.121540Evidence on tissue expression from TISSUES for WNT10A Gene
- Nervous system(4.5)
- Skin(2.6)
- Kidney(2.6)
- Intestine(2.3)
- Muscle(2.2)
- Bone(2.2)
- Blood(2.1)
- Heart(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT10A Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- chin
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- scalp
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- skin
- spinal column
- sweat gland
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for WNT10A
-
OriGene qPCR primer pairs and template standards for WNT10A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WNT10A Gene
Orthologs for WNT10A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WNT10A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WNT10A 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WNT10A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Wnt10a 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wnt10a 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | WNT10A 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | WNT10A 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WNT10A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wnt10a 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wnt10a 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Wnt10 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | egl-20 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for WNT10A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WNT10A Gene
- ENSEMBL:
- Gene Tree for WNT10A (if available)
- TreeFam:
- Gene Tree for WNT10A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WNT10A: view image
Paralogs for WNT10A Gene
Paralogs for WNT10A Gene
(10) SIMAP similar genes for WNT10A Gene using alignment to 3 proteins:
- WN10A_HUMAN
- H7BZB8_HUMAN
- Q05BQ6_HUMAN
Variants for WNT10A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT10A Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639357 | Pathogenic: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,298(+) | TC/T | FRAMESHIFT_VARIANT | |
| 642382 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,893,102(+) | G/T | MISSENSE_VARIANT | |
| 646775 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,161(+) | G/A | MISSENSE_VARIANT | |
| 654586 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,893,096(+) | G/T | MISSENSE_VARIANT | |
| 660265 | Uncertain Significance: Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia | 218,890,363(+) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.48;
55.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WNT10A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10A Gene
Disorders for WNT10A Gene
(18) MalaCards diseases for WNT10A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schopf-schulz-passarge syndrome |
|
|
| odontoonychodermal dysplasia |
|
|
| tooth agenesis, selective, 4 |
|
|
| hypohidrotic ectodermal dysplasia autosomal recessive |
|
|
| tooth agenesis |
|
|
Search WNT10A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WN10A_HUMAN- Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin. {ECO:0000269 PubMed:17847007, ECO:0000269 PubMed:19471313, ECO:0000269 PubMed:19559398, ECO:0000269 PubMed:24458874, ECO:0000269 PubMed:28589954}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms. {ECO:0000269 PubMed:19559398, ECO:0000269 PubMed:21143469}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Tooth agenesis, selective, 4 (STHAG4) [MIM:150400]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive. {ECO:0000269 PubMed:20979233, ECO:0000269 PubMed:21484994, ECO:0000269 PubMed:22581971, ECO:0000269 PubMed:23401279, ECO:0000269 PubMed:24311251, ECO:0000269 PubMed:24449199, ECO:0000269 PubMed:27657131, ECO:0000269 PubMed:29178643}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for WNT10A
- Genetic Association Database
- (GAD)
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No data available for Genatlas for WNT10A Gene
Publications for WNT10A Gene
- Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PMID: 17847007) Adaimy L … Megarbane A (American journal of human genetics 2007) 2 3 4
- WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. (PMID: 11350055) Kirikoshi H … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4
- WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. (PMID: 28589954) Xu M … Millar SE (Nature communications 2017) 3 4
- WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations. (PMID: 24449199) Arzoo PS … Dahl N (American journal of medical genetics. Part A 2014) 3 4
- WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity. (PMID: 24311251) Kantaputra P … Kantaputra W (American journal of medical genetics. Part A 2014) 3 4
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