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Aliases for WNK4 Gene

Aliases for WNK4 Gene

  • WNK Lysine Deficient Protein Kinase 4 2 3 5
  • Protein Kinase Lysine-Deficient 4 3 4
  • Protein Kinase With No Lysine 4 3 4
  • EC 2.7.11.1 4 56
  • PRKWNK4 3 4
  • Serine/Threonine-Protein Kinase WNK4 3
  • Protein Kinase, Lysine Deficient 4 2
  • EC 2.7.11 56
  • PHA2B 3

External Ids for WNK4 Gene

Previous HGNC Symbols for WNK4 Gene

  • PRKWNK4

Previous GeneCards Identifiers for WNK4 Gene

  • GC17P038188
  • GC17P040932
  • GC17P036697
  • GC17P042780
  • GC17P042881
  • GC17P042942
  • GC17P042896
  • GC17P042891
  • GC17P043039
  • GC17P043103

Summaries for WNK4 Gene

Entrez Gene Summary for WNK4 Gene

  • This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]

GeneCards Summary for WNK4 Gene

WNK4 (WNK Lysine Deficient Protein Kinase 4) is a Protein Coding gene. Diseases associated with WNK4 include Pseudohypoaldosteronism, Type Iib and Pseudohypoaldosteronism. Among its related pathways are Diuretics Pathway, Pharmacodynamics and Ion channel transport. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot for WNK4 Gene

  • Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Gene Wiki entry for WNK4 Gene

Additional gene information for WNK4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNK4 Gene

Genomics for WNK4 Gene

GeneHancer (GH) Regulatory Elements for WNK4 Gene

Promoters and enhancers for WNK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042778 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.8 +0.6 646 3.6 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 POLR2B WNK4 GC17P043538 PIR58321 HMGN2P15 EZH1 AOC4P VPS25
GH17I042823 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.4 +44.4 44404 1.7 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B MIR6781 PSME3 BECN1 CNTD1 COA3 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2
GH17I042419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.7 -357.7 -357729 5.2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B CAVIN1 LOC102725238 LINC00910 HMGN1P29 NBR2 ENSG00000267758 DHX58 PSME3 CNTD1 RETREG3
GH17I042802 Enhancer 0.8 ENCODE 12.1 +25.3 25343 4.3 FOXA2 ARID4B RARA ETS1 ZNF121 SMARCC2 CREM THAP11 MIXL1 SP1 WNK4 VPS25 RAMP2-AS1 RAMP2 HMGN2P15 EZH1 AOC2 AOC3 PSMC3IP AOC4P
GH17I042623 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.7 -155.5 -155469 1.9 PKNOX1 ATF1 ARNT IRF4 GTF3C2 TCF12 ZNF766 GATA2 ZNF143 ATF7 TUBG2 WNK4 RETREG3 ATP5MGP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNK4 gene promoter:

Genomic Locations for WNK4 Gene

Genomic Locations for WNK4 Gene
chr17:42,779,673-42,797,066
(GRCh38/hg38)
Size:
17,394 bases
Orientation:
Plus strand
chr17:40,932,649-40,949,084
(GRCh37/hg19)

Genomic View for WNK4 Gene

Genes around WNK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNK4 Gene

Proteins for WNK4 Gene

  • Protein details for WNK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J92-WNK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase WNK4
    Protein Accession:
    Q96J92
    Secondary Accessions:
    • B0LPI0
    • Q8N8X3
    • Q8N8Z2
    • Q96DT8
    • Q9BYS5

    Protein attributes for WNK4 Gene

    Size:
    1243 amino acids
    Molecular mass:
    134739 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the C-terminal region of KCNJ1 (By similarity). Interacts with WNK1 and WNK3 (By similarity). Interacts with KLHL3 (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031, PubMed:26435498, PubMed:27727489).
    SequenceCaution:
    • Sequence=BAC04669.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC48387.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WNK4 Gene

    Alternative splice isoforms for WNK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNK4 Gene

Selected DME Specific Peptides for WNK4 Gene

Q96J92:
  • ILHRDLK
  • EIGRGSF
  • EYPYSEC
  • KIGDLGLA
  • VIGTPEFMAPE
  • PEVKEIIEGCIR
  • FGMCMLEM
  • SSEESESS
  • TELMTSGTL
  • GTPEFMAPE

Post-translational modifications for WNK4 Gene

  • Phosphorylated by WNK1 and WNK3.
  • Ubiquitinated by the BCR(KLHL3) complex, leading to its degradation and increased expression of KCNJ1 at the cell surface. Ubiquitinated by the BCR(KLHL2) complex.
  • Ubiquitination at posLast=157157, posLast=175175, posLast=186186, posLast=226226, isoforms=3241, posLast=328328, posLast=387387, posLast=393393, isoforms=2, 3450, posLast=454454, isoforms=31010, isoforms=31144, posLast=11571157, and isoforms=1158
  • Modification sites at PhosphoSitePlus

Domains & Families for WNK4 Gene

Gene Families for WNK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96J92

UniProtKB/Swiss-Prot:

WNK4_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
genes like me logo Genes that share domains with WNK4: view

Function for WNK4 Gene

Molecular function for WNK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation requires autophosphorylation of Ser-335. Phosphorylation of Ser-331 also promotes increased activity (By similarity).
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Enzyme Numbers (IUBMB) for WNK4 Gene

Gene Ontology (GO) - Molecular Function for WNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,ISS --
GO:0005515 protein binding IPI 17721439
GO:0005524 ATP binding ISS,IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with WNK4: view
genes like me logo Genes that share phenotypes with WNK4: view

Human Phenotype Ontology for WNK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNK4 Gene

MGI Knock Outs for WNK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNK4

miRNA for WNK4 Gene

miRTarBase miRNAs that target WNK4

Clone Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for WNK4 Gene

Localization for WNK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNK4 Gene

Cell junction, tight junction. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex. {ECO:0000250 UniProtKB:Q80UE6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNK4 gene
Compartment Confidence
cytosol 4
plasma membrane 2
nucleus 2
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS,IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane ISS,IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with WNK4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNK4 Gene

Pathways & Interactions for WNK4 Gene

genes like me logo Genes that share pathways with WNK4: view

Pathways by source for WNK4 Gene

1 GeneGo (Thomson Reuters) pathway for WNK4 Gene
1 Cell Signaling Technology pathway for WNK4 Gene

Gene Ontology (GO) - Biological Process for WNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006811 ion transport IEA,ISS --
GO:0006821 chloride transport IEA --
GO:0008104 protein localization IEA --
GO:0010766 negative regulation of sodium ion transport IEA,ISS --
genes like me logo Genes that share ontologies with WNK4: view

No data available for SIGNOR curated interactions for WNK4 Gene

Drugs & Compounds for WNK4 Gene

(7) Drugs for WNK4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(6) Additional Compounds for WNK4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with WNK4: view

Transcripts for WNK4 Gene

Unigene Clusters for WNK4 Gene

WNK lysine deficient protein kinase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNK4 Gene

No ASD Table

Relevant External Links for WNK4 Gene

GeneLoc Exon Structure for
WNK4
ECgene alternative splicing isoforms for
WNK4

Expression for WNK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNK4 Gene

This gene is overexpressed in Colon - Transverse (x9.4), Kidney - Cortex (x8.9), Esophagus - Mucosa (x6.2), and Prostate (x5.6).

Protein differential expression in normal tissues from HIPED for WNK4 Gene

This gene is overexpressed in Heart (53.9) and Rectum (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WNK4 Gene



Protein tissue co-expression partners for WNK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of WNK4 Gene:

WNK4

SOURCE GeneReport for Unigene cluster for WNK4 Gene:

Hs.105448

mRNA Expression by UniProt/SwissProt for WNK4 Gene:

Q96J92-WNK4_HUMAN
Tissue specificity: Expressed in kidney, colon and skin.

Evidence on tissue expression from TISSUES for WNK4 Gene

  • Kidney(4.6)
  • Blood(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNK4 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • skeletal muscle
  • urinary
Regions:
Head and neck:
  • ear
Thorax:
  • heart
  • heart valve
Abdomen:
  • intestine
  • kidney
  • large intestine
  • small intestine
General:
  • blood vessel
genes like me logo Genes that share expression patterns with WNK4: view

Orthologs for WNK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WNK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNK4 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia WNK4 33 34
  • 88.78 (n)
dog
(Canis familiaris)
Mammalia WNK4 33 34
  • 87.23 (n)
mouse
(Mus musculus)
Mammalia Wnk4 33 16 34
  • 85.31 (n)
rat
(Rattus norvegicus)
Mammalia Wnk4 33
  • 84.96 (n)
oppossum
(Monodelphis domestica)
Mammalia WNK4 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNK4 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777580 33
  • 70.94 (n)
WNK4 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNK4 34
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii WNK4 (1 of 4) 34
  • 87 (a)
OneToMany
WNK4 (3 of 4) 34
  • 37 (a)
OneToMany
CABZ01069042.1 34
  • 31 (a)
OneToMany
CABZ01084815.1 34
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnk 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wnk-1 34
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os11g0160300 33
  • 51.62 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.28467 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
OneToMany
Species where no ortholog for WNK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for WNK4 Gene

ENSEMBL:
Gene Tree for WNK4 (if available)
TreeFam:
Gene Tree for WNK4 (if available)

Paralogs for WNK4 Gene

Paralogs for WNK4 Gene

genes like me logo Genes that share paralogs with WNK4: view

Variants for WNK4 Gene

Sequence variations from dbSNP and Humsavar for WNK4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs117902541 likely-benign, Pseudohypoaldosteronism, type 2 42,796,209(+) C/A/G/T coding_sequence_variant, missense_variant
rs137853092 pathogenic, Pseudohypoaldosteronism type 2B, Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491] 42,787,494(+) C/G coding_sequence_variant, missense_variant
rs137853093 pathogenic, Pseudohypoaldosteronism type 2B, Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491] 42,787,485(+) G/A coding_sequence_variant, missense_variant
rs137853094 pathogenic, Pseudohypoaldosteronism type 2B, Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491] 42,787,492(+) A/C coding_sequence_variant, missense_variant
rs137853095 pathogenic, Pseudohypoaldosteronism type 2B, Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491] 42,796,244(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for WNK4 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv827998 CNV loss 20364138
nsv833450 CNV loss 17160897

Variation tolerance for WNK4 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNK4 Gene

Human Gene Mutation Database (HGMD)
WNK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNK4 Gene

Disorders for WNK4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WNK4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search WNK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNK4_HUMAN
  • Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491]: An autosomal dominant disorder characterized by hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. {ECO:0000269 PubMed:11498583, ECO:0000269 PubMed:23387299, ECO:0000269 PubMed:23453970, ECO:0000269 PubMed:23576762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WNK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNK4: view

No data available for Genatlas for WNK4 Gene

Publications for WNK4 Gene

  1. Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population. (PMID: 19340547) Sun ZJ … Zhao YY (The journal of physiological sciences : JPS 2009) 3 22 44 58
  2. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PMID: 15824464) Matayoshi T … Kawano Y (Hypertension research : official journal of the Japanese Society of Hypertension 2004) 3 22 44 58
  3. WNK4 intron 10 polymorphism is not associated with hypertension. (PMID: 14967840) Speirs HJ … Morris BJ (Hypertension (Dallas, Tex. : 1979) 2004) 3 22 44 58
  4. Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. (PMID: 15309683) Kokubo Y … Miyata T (Journal of human genetics 2004) 3 22 44 58
  5. Genetic variants of WNK4 in whites and African Americans with hypertension. (PMID: 12719438) Erlich PM … DeStefano AL (Hypertension (Dallas, Tex. : 1979) 2003) 3 22 44 58

Products for WNK4 Gene

Sources for WNK4 Gene

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