This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a ca... See more...

Aliases for WNK3 Gene

Aliases for WNK3 Gene

  • WNK Lysine Deficient Protein Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase WNK3 3 4
  • Protein Kinase With No Lysine 3 3 4
  • EC 2.7.11.1 4 50
  • PRKWNK3 3 4
  • Protein Kinase, Lysine Deficient 3 2
  • Protein Kinase Lysine-Deficient 3 4
  • EC 2.7.11 50
  • KIAA1566 4
  • WNK3 5

External Ids for WNK3 Gene

Previous HGNC Symbols for WNK3 Gene

  • PRKWNK3

Previous GeneCards Identifiers for WNK3 Gene

  • GC0XM054106
  • GC0XM054235
  • GC0XM051270

Summaries for WNK3 Gene

Entrez Gene Summary for WNK3 Gene

  • This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for WNK3 Gene

WNK3 (WNK Lysine Deficient Protein Kinase 3) is a Protein Coding gene. Diseases associated with WNK3 include Hypomagnesemia 4, Renal and Syndromic X-Linked Intellectual Disability Siderius Type. Among its related pathways are Ion channel transport and Diuretics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot Summary for WNK3 Gene

  • Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
  • Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.

Gene Wiki entry for WNK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNK3 Gene

Genomics for WNK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ054439 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.2 -82.3 -82306 3.2 ZNF654 NCOR1 MYC POLR2A YY1 CEBPB REST SMAD5 ETS1 BHLHE40 HSALNG0138057 TSR2 WNK3 GNL3L PHF8 HUWE1 HSALNG0138063 FGD1
GH0XJ054357 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.6 594 3.4 ZNF10 POLR2A ETS1 ZNF341 SIN3A KLF9 ZNF610 SP2 ZBTB33 YY1 WNK3 lnc-TSR2-9 RF00017-7851 RF00026-1126 RNU6-434P FAM120C
GH0XJ054344 Promoter 0.3 EPDnew 250.4 +13.9 13895 0.1 RNU6-434P RF00026-1126 WNK3 lnc-TSR2-9 RF00017-7851 FAM120C
GH0XJ054408 Enhancer 0.3 Ensembl 13.7 -50.4 -50406 1.4 POLR2A CEBPG WNK3 TSR2 hsa-miR-5095-532 lnc-TSR2-6
GH0XJ054413 Enhancer 0.5 Ensembl 0.2 -55.4 -55406 0.2 CEBPA SMAD4 BCL6 POLR2A TCF7 CEBPG HLF RUNX3 lnc-TSR2-6 hsa-miR-5095-532 TSR2 WNK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNK3

Top Transcription factor binding sites by QIAGEN in the WNK3 gene promoter:
  • AhR
  • Arnt
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx2-5
  • Pax-4a
  • RFX1
  • RREB-1

Genomic Locations for WNK3 Gene

Latest Assembly
chrX:54,192,823-54,358,695
(GRCh38/hg38)
Size:
165,873 bases
Orientation:
Minus strand

Previous Assembly
chrX:54,219,256-54,384,479
(GRCh37/hg19 by Entrez Gene)
Size:
165,224 bases
Orientation:
Minus strand

chrX:54,219,256-54,385,075
(GRCh37/hg19 by Ensembl)
Size:
165,820 bases
Orientation:
Minus strand

Genomic View for WNK3 Gene

Genes around WNK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNK3 Gene

Proteins for WNK3 Gene

  • Protein details for WNK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYP7-WNK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase WNK3
    Protein Accession:
    Q9BYP7
    Secondary Accessions:
    • B1AKG2
    • Q5JRC1
    • Q6JP76
    • Q8TCX6
    • Q9HCK6

    Protein attributes for WNK3 Gene

    Size:
    1800 amino acids
    Molecular mass:
    198416 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with WNK1 and WNK4.

    Three dimensional structures from OCA and Proteopedia for WNK3 Gene

    Alternative splice isoforms for WNK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNK3 Gene

Selected DME Specific Peptides for WNK3 Gene

Q9BYP7:
  • FTDDLHKLVD
  • PPIIHRD
  • QRFKEEAEMLKGLQHPNIVRFYDSWES
  • EYPYSEC
  • KMVTFKFD
  • KIGDLGLA
  • VIGTPEFMAPE
  • PEVKEIIEGCIR
  • FGMCMLEM
  • TELMTSGTL
  • KDNEAIEFSF
  • KVTSGIKP
  • GTPEFMAPE
  • DLLNHAFF
  • IHRDLKCDNIF
  • YDESVDV
  • VEVAWCELQDRKLTK

Post-translational modifications for WNK3 Gene

  • Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for WNK3
  • Boster Bio Antibodies for WNK3

Domains & Families for WNK3 Gene

Gene Families for WNK3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WNK3 Gene

GenScript: Design optimal peptide antigens:
  • WNK lysine deficient protein kinase 3 (B1AKG2_HUMAN)
  • WNK lysine deficient protein kinase 3 (B1AQN8_HUMAN)
  • Protein kinase with no lysine 3 (WNK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYP7

UniProtKB/Swiss-Prot:

WNK3_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
genes like me logo Genes that share domains with WNK3: view

Function for WNK3 Gene

Molecular function for WNK3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
UniProtKB/Swiss-Prot Function:
Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:17975670};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:17975670};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes increased activity (By similarity). Kinase activity is inhibited by WNK4.

Enzyme Numbers (IUBMB) for WNK3 Gene

Phenotypes From GWAS Catalog for WNK3 Gene

Gene Ontology (GO) - Molecular Function for WNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IDA 16275913
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005515 protein binding IPI 16501604
GO:0005524 ATP binding IEA,ISS --
genes like me logo Genes that share ontologies with WNK3: view
genes like me logo Genes that share phenotypes with WNK3: view

Animal Models for WNK3 Gene

MGI Knock Outs for WNK3:
  • Wnk3 Wnk3<tm1.1Esoh>

Animal Models for research

  • Taconic Biosciences Mouse Models for WNK3

miRNA for WNK3 Gene

miRTarBase miRNAs that target WNK3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNK3 Gene

Localization for WNK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNK3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNK3 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 16501604
GO:0005829 cytosol IBA 21873635
GO:0005912 adherens junction ISS --
GO:0005923 bicellular tight junction ISS --
genes like me logo Genes that share ontologies with WNK3: view

Pathways & Interactions for WNK3 Gene

genes like me logo Genes that share pathways with WNK3: view

Pathways by source for WNK3 Gene

SIGNOR curated interactions for WNK3 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for WNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006884 cell volume homeostasis ISS 27782176
GO:0007231 osmosensory signaling pathway IMP 27782176
GO:0010765 positive regulation of sodium ion transport IDA 16275913
GO:0010766 negative regulation of sodium ion transport IBA 21873635
genes like me logo Genes that share ontologies with WNK3: view

Drugs & Compounds for WNK3 Gene

(2) Drugs for WNK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for WNK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with WNK3: view

Transcripts for WNK3 Gene

mRNA/cDNA for WNK3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK3

Alternative Splicing Database (ASD) splice patterns (SP) for WNK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1:
SP2: - -

ExUns: 24b
SP1:
SP2:

Relevant External Links for WNK3 Gene

GeneLoc Exon Structure for
WNK3

Expression for WNK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNK3 Gene

This gene is overexpressed in Testis (x9.1).

Protein differential expression in normal tissues from HIPED for WNK3 Gene

This gene is overexpressed in Testis (31.9), Fetal Brain (17.2), Lung (8.9), and Ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WNK3 Gene



Protein tissue co-expression partners for WNK3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNK3

SOURCE GeneReport for Unigene cluster for WNK3 Gene:

Hs.92423

mRNA Expression by UniProt/SwissProt for WNK3 Gene:

Q9BYP7-WNK3_HUMAN
Tissue specificity: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific.

Evidence on tissue expression from TISSUES for WNK3 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with WNK3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNK3 Gene

Orthologs for WNK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WNK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WNK3 29 30
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WNK3 29
  • 90.07 (n)
Cow
(Bos Taurus)
Mammalia WNK3 29 30
  • 89.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wnk3 29 16 30
  • 86.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnk3 29
  • 85.86 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WNK3 30
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WNK3 30
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 85 (a)
OneToMany
-- 30
  • 39 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii WNK3 30
  • 42 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Wnk 30
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea wnk-1 30
  • 23 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11318 29
Rice
(Oryza sativa)
Liliopsida Os.18183 29
Corn
(Zea mays)
Liliopsida Zm.1174 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 78 (a)
OneToMany
Species where no ortholog for WNK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for WNK3 Gene

ENSEMBL:
Gene Tree for WNK3 (if available)
TreeFam:
Gene Tree for WNK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNK3: view image
Alliance of Genome Resources:
Additional Orthologs for WNK3

Paralogs for WNK3 Gene

Paralogs for WNK3 Gene

(5) SIMAP similar genes for WNK3 Gene using alignment to 2 proteins:

  • WNK3_HUMAN
  • B1AQN8_HUMAN
genes like me logo Genes that share paralogs with WNK3: view

Variants for WNK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNK3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
872363 Uncertain Significance: not provided 54,248,887(-) G/A
NM_020922.4(WNK3):c.3461C>T (p.Ser1154Phe)
MISSENSE
rs1057524673 Uncertain Significance: not provided 54,237,299(-) T/G
NM_020922.4(WNK3):c.4267A>C (p.Ser1423Arg)
MISSENSE
rs139877996 Benign: not provided 54,294,656(-) G/A
NM_020922.4(WNK3):c.1590C>T (p.Pro530=)
SYNONYMOUS
rs140682208 Benign: not provided 54,249,609(-) T/C
NM_020922.4(WNK3):c.2739A>G (p.Glu913=)
SYNONYMOUS
rs146391543 Benign: not provided 54,298,334(-) C/T
NM_020922.4(WNK3):c.1239G>A (p.Val413=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WNK3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WNK3 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for WNK3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNK3 Gene

Human Gene Mutation Database (HGMD)
WNK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNK3
Leiden Open Variation Database (LOVD)
WNK3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNK3 Gene

Disorders for WNK3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for WNK3 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search WNK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNK3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WNK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNK3 Gene

Publications for WNK3 Gene

  1. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. (PMID: 19470686) Glover M … O'Shaughnessy KM (Journal of the American Society of Nephrology : JASN 2009) 3 4 22
  2. Autism-associated familial microdeletion of Xp11.22. (PMID: 18498374) Qiao Y … Lewis ME (Clinical genetics 2008) 3 22 40
  3. Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. (PMID: 16501604) Veríssimo F … Jordan P (Oncogene 2006) 3 4 22
  4. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. (PMID: 16275913) Rinehart J … Lifton RP (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22
  5. Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). (PMID: 15194194) Holden S … Raymond FL (Gene 2004) 3 4 22

Products for WNK3 Gene

Sources for WNK3 Gene