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The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
WNK2 (WNK Lysine Deficient Protein Kinase 2) is a Protein Coding gene. Diseases associated with WNK2 include Hypomagnesemia 4, Renal and Angiomatous Meningioma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,ISS | -- |
GO:0005524 | ATP binding | IEA,ISS | -- |
GO:0016301 | kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA,IDA | 17667937 |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ion channel transport | ||
2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA,IDA | 21733846 |
GO:0008285 | negative regulation of cell proliferation | IMP | 17667937 |
GO:0010766 | negative regulation of sodium ion transport | IBA | 21873635 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0035556 | intracellular signal transduction | ISS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: |
ExUns: | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: | |||||||||||||||||||||||||||||||||||||||||||||||
SP15: | |||||||||||||||||||||||||||||||||||||||||||||||
SP16: | |||||||||||||||||||||||||||||||||||||||||||||||
SP17: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WNK2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Wnk2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wnk2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | WNK2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WNK2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | WNK2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WNK2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | WNK2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WNK2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wnk2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | WNK2 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2383 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Wnk 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | wnk-1 31 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.2463 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.2221 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs112172724 | Benign: not provided | 93,259,271(+) |
G/C NM_006648.3(WNK2):c.2723G>C (p.Gly908Ala) |
MISSENSE | |
rs112615506 | Benign: not provided | 93,234,799(+) |
C/T NM_006648.3(WNK2):c.1076-9C>T |
INTRON | |
rs115314798 | Benign: not provided | 93,308,395(+) |
G/A NM_006648.3(WNK2):c.6327G>A (p.Ala2109=) |
SYNONYMOUS | |
rs143326467 | Benign: not provided | 93,288,984(+) |
G/A NM_006648.3(WNK2):c.4230G>A (p.Ala1410=) |
SYNONYMOUS | |
rs35032940 | Likely Benign: not provided | 93,293,010(+) |
C/T NM_006648.3(WNK2):c.5545C>T (p.Arg1849Trp) |
MISSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1441694 | CNV | insertion | 17803354 |
esv1576972 | CNV | insertion | 17803354 |
esv2506086 | CNV | insertion | 19546169 |
esv2668317 | CNV | deletion | 23128226 |
esv2738781 | CNV | deletion | 23290073 |
esv2738782 | CNV | deletion | 23290073 |
esv3310587 | CNV | novel sequence insertion | 20981092 |
esv3331340 | CNV | duplication | 20981092 |
nsv1117518 | CNV | tandem duplication | 24896259 |
nsv1117519 | CNV | tandem duplication | 24896259 |
nsv1129825 | CNV | tandem duplication | 24896259 |
nsv1137482 | CNV | deletion | 24896259 |
nsv1161884 | CNV | deletion | 26073780 |
nsv1161885 | CNV | duplication | 26073780 |
nsv415527 | CNV | deletion | 16902084 |
nsv415569 | CNV | deletion | 16902084 |
nsv415836 | CNV | deletion | 16902084 |
nsv509310 | CNV | insertion | 20534489 |
nsv526296 | CNV | loss | 19592680 |
nsv614880 | CNV | loss | 21841781 |
nsv824983 | CNV | gain | 20364138 |
nsv950897 | CNV | deletion | 24416366 |
nsv950898 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypomagnesemia 4, renal |
|
|
angiomatous meningioma |
|
|
olfactory groove meningioma |
|
|
meningioma, familial |
|
|
anterior cranial fossa meningioma |
|
|