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The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] See more...
Aliases for WNK2 Gene
Aliases for WNK2 Gene
External Ids for WNK2 Gene
- HGNC: 14542
- Entrez Gene: 65268
- Ensembl: ENSG00000165238
- OMIM: 606249
- UniProtKB: Q9Y3S1
Previous HGNC Symbols for WNK2 Gene
- SDCCAG43
- PRKWNK2
Previous GeneCards Identifiers for WNK2 Gene
- GC09P093027
- GC09P094987
- GC09P095947
- GC09P065623
Summaries for WNK2 Gene
-
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for WNK2 Gene
WNK2 (WNK Lysine Deficient Protein Kinase 2) is a Protein Coding gene. Diseases associated with WNK2 include Meningioma, Familial and Hypomagnesemia 4, Renal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.
UniProtKB/Swiss-Prot Summary for WNK2 Gene
-
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Additional gene information for WNK2 Gene
- HGNC(14542)
- Entrez Gene(65268)
- Ensembl(ENSG00000165238)
- OMIM(606249)
- UniProtKB(Q9Y3S1)
- Open Targets Platform(ENSG00000165238)
- Search for WNK2 at DataMed
- Search for WNK2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNK2 Gene
Genomics for WNK2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WNK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WNK2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNK2
- Top Transcription factor binding sites by QIAGEN in the WNK2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- C/EBPbeta
- Egr-4
- Evi-1
- Lmo2
- MyoD
- Pax-4a
- RP58
Genomic Locations for WNK2 Gene
Genomic Locations for WNK2 Gene
- chr9:93,184,156-93,327,581
- (GRCh38/hg38)
- Size:
- 143,426 bases
- Orientation:
- Plus strand
- chr9:95,947,198-96,082,854
- (GRCh37/hg19)
- Size:
- 135,657 bases
- Orientation:
- Plus strand
Genomic View for WNK2 Gene
Genes around WNK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.31 by HGNC
- 9q22.31 by Entrez Gene
- 9q22.31 by Ensembl
WNK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WNK2 Gene
Proteins for WNK2 Gene
-
Protein details for WNK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3S1-WNK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase WNK2
- Protein Accession:
- Q9Y3S1
- Q5VWF1
- Q5VWF2
- Q8IY36
- Q9C0A3
- Q9H3P4
Protein attributes for WNK2 Gene
- Size:
- 2297 amino acids
- Molecular mass:
- 242676 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Forms a complex with the phosphorylated form of STK39.
- SequenceCaution:
-
- Sequence=AAH37965.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: Incomplete sequence.
Protein Expression for WNK2 Gene
Selected DME Specific Peptides for WNK2 Gene
- Q9Y3S1:
-
- FTDDLHKLVD
- PPIIHRD
- EYPYSEC
- IEQMKDV
- KMVTFKFD
- KIGDLGLA
- VIGTPEFMAPE
- FGMCMLEM
- TELMTSGTL
- GTPEFMAPE
- IHRDLKCDNIF
- YDESVDV
- VEVAWCELQDRKLTK
Post-translational modifications for WNK2 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for WNK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005252194.1
- XP_005252197.1
- XP_005252198.1
- XP_005252201.1
- XP_011517228.1
- XP_011517229.1
- XP_011517230.1
- XP_011517231.1
- XP_011517232.1
- XP_011517233.1
- XP_011517234.1
- XP_011517237.1
- XP_011517238.1
- XP_011517239.1
- XP_011517241.1
- XP_011517242.1
- XP_016870534.1
- XP_016870535.1
- XP_016870536.1
- XP_016870537.1
- XP_016870538.1
- XP_016870539.1
- XP_016870540.1
- XP_016870541.1
- XP_016870542.1
- XP_016870543.1
- XP_016870544.1
- NP_001269323.1
- NP_006639.3
Antibody Products
- G Biosciences Immunotag™ WNK2 Antibody
- Creative Diagnostics Anti-WNK2 monoclonal antibody, clone 3F21
- Creative Biolabs Recombinant Anti-Human WNK2 Antibody scFv Fragment and Recombinant Anti-Human WNK2 Antibody
- Novus Biologicals Antibodies for WNK2
-
Abcam antibodies for WNK2
- Invitrogen Antibodies for WNK2 (AFLGC-WNK2)
-
Biorbyt antibodies for WNK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for WNK2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for WNK2
- Origene Custom Protein Services for WNK2
- Novus Biologicals proteins for WNK2
-
Abcam proteins for WNK2
Domains & Families for WNK2 Gene
Gene Families for WNK2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for WNK2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for WNK2 Gene
- GenScript: Design optimal peptide antigens:
-
- WNK lysine deficient protein kinase 2 (A6PVR2_HUMAN)
- WNK lysine deficient protein kinase 2 (A6PVR3_HUMAN)
- WNK lysine deficient protein kinase 2 (A6PVR4_HUMAN)
- WNK lysine deficient protein kinase 2 (A6PVV2_HUMAN)
- Serologically defined colon cancer antigen 43 (WNK2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y3S1UniProtKB/Swiss-Prot:
WNK2_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Function for WNK2 Gene
Molecular function for WNK2 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9H4A3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9H4A3};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity (By similarity).
Enzyme Numbers (IUBMB) for WNK2 Gene
Phenotypes From GWAS Catalog for WNK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,ISS | -- |
| GO:0005524 | ATP binding | IEA,ISS | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for WNK2 Gene
- GenomeRNAi human phenotypes for WNK2:
-
- no effect
- Increased cell death HMECs cells
- Dynamic nuclei (hole, folded or small irregular)
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance
- Decreased viability
- Decreased viability in pancreas lineage
- Decreased ionizing radiation sensitivity
- Decreased transferrin (TF) endocytosis
- Decreased simian virus 40 (SV40) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for WNK2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNK2 - Select products 50% OFF >
- * WNK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WNK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNK2
miRNA for WNK2 Gene
- miRTarBase miRNAs that target WNK2
-
- hsa-miR-222-5p (MIRT491914)
- hsa-miR-4654 (MIRT491915)
- hsa-miR-4769-5p (MIRT491916)
- hsa-miR-6778-5p (MIRT491917)
- hsa-miR-1233-5p (MIRT491918)
- hsa-miR-4648 (MIRT491919)
- hsa-miR-5196-5p (MIRT491920)
- hsa-miR-4493 (MIRT491921)
- hsa-miR-4747-5p (MIRT491922)
- hsa-miR-134-3p (MIRT491923)
- hsa-miR-7114-5p (MIRT491924)
- hsa-miR-3129-5p (MIRT491925)
- hsa-miR-199b-3p (MIRT491926)
- hsa-miR-199a-3p (MIRT491927)
- hsa-miR-936 (MIRT491929)
- hsa-miR-629-3p (MIRT713193)
- hsa-miR-519e-5p (MIRT713194)
- hsa-miR-515-5p (MIRT713195)
- hsa-miR-760 (MIRT713196)
- hsa-miR-3160-5p (MIRT713197)
- hsa-miR-3194-3p (MIRT713198)
- hsa-miR-3925-3p (MIRT713199)
- hsa-miR-766-3p (MIRT713200)
- hsa-miR-4267 (MIRT713201)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WNK2
- Browse OriGene Inhibitory RNA Products For WNK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK2
Clone Products
- Applied Biological Materials (abm): Clones for WNK2 - Select products 50% OFF >
- * WNK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WNK2
- Addgene plasmids for WNK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNK2
Cell Line Products
-
Horizon Cell Lines for WNK2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WNK2 Gene
Localization for WNK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WNK2 Gene
- Cytoplasm. Cell membrane.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 17667937 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for WNK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ion channel transport | ||
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for WNK2 Gene
3 Reactome pathways for WNK2 Gene
Interacting Proteins for WNK2 Gene
GPS-Prot Interaction Network for WNK2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA,IDA | 21733846 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 17667937 |
| GO:0010766 | negative regulation of sodium ion transport | IBA | 21873635 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | IBA | 21873635 |
Drugs & Compounds for WNK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for WNK2 Gene
mRNA/cDNA for WNK2 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000297954 7138 nts (view in UCSC)
- ENST00000395477 6834 nts (view in UCSC)
- ENST00000411624 6679 nts (view in UCSC)
- ENST00000427277 6108 nts (view in UCSC)
- ENST00000432730 7792 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNK2 - Select products 50% OFF >
- * WNK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WNK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNK2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WNK2
- Browse OriGene Inhibitory RNA Products For WNK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK2
Clone Products
- Applied Biological Materials (abm): Clones for WNK2 - Select products 50% OFF >
- * WNK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WNK2
- Addgene plasmids for WNK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNK2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
Relevant External Links for WNK2 Gene
- GeneLoc Exon Structure for
- WNK2
Expression for WNK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for WNK2 Gene
This gene is overexpressed in Heart - Atrial Appendage (x5.4) and Heart - Left Ventricle (x4.8).
This gene is overexpressed in Retina (14.5), Frontal cortex (8.2), Spleen (8.1), Pancreas (7.1), and Salivary gland (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WNK2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNK2
SOURCE GeneReport for Unigene cluster for WNK2 Gene:
Hs.654856mRNA Expression by UniProt/SwissProt for WNK2 Gene:
Q9Y3S1-WNK2_HUMAN
Tissue specificity:
Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
Evidence on tissue expression from TISSUES for WNK2 Gene
- Nervous system(4.5)
- Heart(2.5)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for WNK2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNK2 Gene
Orthologs for WNK2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WNK2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Wnk2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wnk2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | WNK2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WNK2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | WNK2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WNK2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WNK2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WNK2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wnk2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | WNK2 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2383 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Wnk 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | wnk-1 31 |
|
OneToMany | |
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2463 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os.2221 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for WNK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WNK2 Gene
- ENSEMBL:
- Gene Tree for WNK2 (if available)
- TreeFam:
- Gene Tree for WNK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WNK2: view image
Paralogs for WNK2 Gene
(7) SIMAP similar genes for WNK2 Gene using alignment to 11 proteins:
- WNK2_HUMAN
- A6PVV2_HUMAN
- A8MQ23_HUMAN
- C9JGD6_HUMAN
- E9PCD1_HUMAN
- F8W7S2_HUMAN
- F8W9F9_HUMAN
- H0Y493_HUMAN
- H0Y7J9_HUMAN
- H0Y7R3_HUMAN
- H0Y7T5_HUMAN
Variants for WNK2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNK2 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711710 | Likely Benign: not provided | 93,293,010(+) | C/T | MISSENSE_VARIANT | |
| 771731 | Likely Benign: not provided | 93,257,029(+) | C/A | MISSENSE_VARIANT | |
| 776434 | Benign: not provided | 93,259,271(+) | G/C | MISSENSE_VARIANT | |
| 778435 | Benign: not provided | 93,256,461(+) | G/A | INTRON_VARIANT | |
| 780820 | Benign: not provided | 93,234,799(+) | C/T | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1441694 | CNV | insertion | 17803354 |
| esv1576972 | CNV | insertion | 17803354 |
| esv2506086 | CNV | insertion | 19546169 |
| esv2668317 | CNV | deletion | 23128226 |
| esv2738781 | CNV | deletion | 23290073 |
| esv2738782 | CNV | deletion | 23290073 |
| esv3310587 | CNV | novel sequence insertion | 20981092 |
| esv3331340 | CNV | duplication | 20981092 |
| nsv1117518 | CNV | tandem duplication | 24896259 |
| nsv1117519 | CNV | tandem duplication | 24896259 |
| nsv1129825 | CNV | tandem duplication | 24896259 |
| nsv1137482 | CNV | deletion | 24896259 |
| nsv1161884 | CNV | deletion | 26073780 |
| nsv1161885 | CNV | duplication | 26073780 |
| nsv415527 | CNV | deletion | 16902084 |
| nsv415569 | CNV | deletion | 16902084 |
| nsv415836 | CNV | deletion | 16902084 |
| nsv509310 | CNV | insertion | 20534489 |
| nsv526296 | CNV | loss | 19592680 |
| nsv614880 | CNV | loss | 21841781 |
| nsv824983 | CNV | gain | 20364138 |
| nsv950897 | CNV | deletion | 24416366 |
| nsv950898 | CNV | deletion | 24416366 |
Gene Damage Index Score:
12.28;
94.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WNK2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNK2 Gene
Disorders for WNK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| meningioma, familial |
|
|
| hypomagnesemia 4, renal |
|
|
| agenesis of the corpus callosum with peripheral neuropathy |
|
|
| angiomatous meningioma |
|
|
| hypomagnesemia 3, renal |
|
|
Search WNK2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WNK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for WNK2 Gene
Publications for WNK2 Gene
- WNK2 modulates MEK1 activity through the Rho GTPase pathway. (PMID: 18593598) Moniz S … Jordan P (Cellular signalling 2008) 3 4 23
- WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. (PMID: 11571656) Veríssimo F … Jordan P (Oncogene 2001) 2 3 4
- WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. (PMID: 21733846) Rinehart J … Lifton RP (The Journal of biological chemistry 2011) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41
ExternalLinks
Products for WNK2 Gene
- Custom Antibody Services
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- Taconic Biosciences Mouse Models for WNK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for WNK2 (AFLGC-WNK2)
- VectorBuilder Custom and pre-made DNA vectors for WNK2 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for WNK2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for WNK2
- Addgene plasmids for WNK2
- antibodies-online: Show 9 available WNK2 Antibodies ranked by validation data
- Compare Top WNK2 Antibodies
- antibodies-online: Search results for available WNK2 related products ranked by validation data
- antibodies-online: Show 4 available WNK2 Proteins ranked by validation data
- Compare Top WNK2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for WNK2
- Search Santa Cruz Biotechnology (SCBT) for WNK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for WNK2
- Horizon Cell Lines for WNK2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNK2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for WNK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK2
- Biorbyt antibodies for WNK2
Sources for WNK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB