The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] See more...

Aliases for WNK2 Gene

Aliases for WNK2 Gene

  • WNK Lysine Deficient Protein Kinase 2 2 3 5
  • Serologically Defined Colon Cancer Antigen 43 2 3 4
  • Serine/Threonine-Protein Kinase WNK2 3 4
  • Protein Kinase Lysine-Deficient 2 3 4
  • Protein Kinase With No Lysine 2 3 4
  • Antigen NY-CO-43 3 4
  • EC 2.7.11.1 4 51
  • NY-CO-43 2 3
  • SDCCAG43 3 4
  • KIAA1760 2 4
  • PRKWNK2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 3
  • P/OKcl.13 3
  • EC 2.7.11 51
  • WNK2 5

External Ids for WNK2 Gene

Previous HGNC Symbols for WNK2 Gene

  • SDCCAG43
  • PRKWNK2

Previous GeneCards Identifiers for WNK2 Gene

  • GC09P093027
  • GC09P094987
  • GC09P095947
  • GC09P065623

Summaries for WNK2 Gene

Entrez Gene Summary for WNK2 Gene

  • The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for WNK2 Gene

WNK2 (WNK Lysine Deficient Protein Kinase 2) is a Protein Coding gene. Diseases associated with WNK2 include Meningioma, Familial and Hypomagnesemia 4, Renal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot Summary for WNK2 Gene

  • Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Gene Wiki entry for WNK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNK2 Gene

Genomics for WNK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J093183 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 607.4 +2.1 2125 5.4 HNRNPL PRDM10 KDM1A RBFOX2 PKNOX1 POLR2A EZH2 GTF2F1 ZNF341 ZFX WNK2 ENSG00000203364 CARD19 lnc-C9orf129-1 FAM120A
GH09J093184 Enhancer 0.5 Ensembl dbSUPER 600.7 -2.0 -1955 0.4 ZFHX2 EGR2 WNK2 CARD19 HSALNG0072830 NINJ1
GH09J093182 Enhancer 0.5 ENCODE dbSUPER 600.7 -1.4 -1402 0.1 ZNF112 NFIA WNK2 NINJ1 HSALNG0072830
GH09J093294 Enhancer 1.3 FANTOM5 Ensembl ENCODE 23.7 +115.7 115745 12.6 HNRNPL GATAD2A CTCF TFE3 NFKBIZ RCOR2 PRDM1 ZIC2 RBFOX2 RXRB WNK2 RNU6-829P SUSD3 C9orf129 FGD3 ZNF484 piR-61776 lnc-C9orf129-1 FAM120A
GH09J093289 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.7 +105.0 105045 2.4 CREB1 GATAD2A TFE3 JUND RXRB CEBPA MNT SOX13 CEBPB RFX1 WNK2 RNU6-829P SUSD3 ENSG00000203364 piR-61776 lnc-C9orf129-1 FAM120A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNK2

Top Transcription factor binding sites by QIAGEN in the WNK2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • Egr-4
  • Evi-1
  • Lmo2
  • MyoD
  • Pax-4a
  • RP58

Genomic Locations for WNK2 Gene

Genomic Locations for WNK2 Gene
chr9:93,184,156-93,327,581
(GRCh38/hg38)
Size:
143,426 bases
Orientation:
Plus strand
chr9:95,947,198-96,082,854
(GRCh37/hg19)
Size:
135,657 bases
Orientation:
Plus strand

Genomic View for WNK2 Gene

Genes around WNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNK2 Gene

Proteins for WNK2 Gene

  • Protein details for WNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3S1-WNK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase WNK2
    Protein Accession:
    Q9Y3S1
    Secondary Accessions:
    • Q5VWF1
    • Q5VWF2
    • Q8IY36
    • Q9C0A3
    • Q9H3P4

    Protein attributes for WNK2 Gene

    Size:
    2297 amino acids
    Molecular mass:
    242676 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with the phosphorylated form of STK39.
    SequenceCaution:
    • Sequence=AAH37965.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Incomplete sequence.

    Three dimensional structures from OCA and Proteopedia for WNK2 Gene

    Alternative splice isoforms for WNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNK2 Gene

Selected DME Specific Peptides for WNK2 Gene

Q9Y3S1:
  • FTDDLHKLVD
  • PPIIHRD
  • EYPYSEC
  • IEQMKDV
  • KMVTFKFD
  • KIGDLGLA
  • VIGTPEFMAPE
  • FGMCMLEM
  • TELMTSGTL
  • GTPEFMAPE
  • IHRDLKCDNIF
  • YDESVDV
  • VEVAWCELQDRKLTK

Post-translational modifications for WNK2 Gene

Domains & Families for WNK2 Gene

Gene Families for WNK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for WNK2 Gene

Suggested Antigen Peptide Sequences for WNK2 Gene

GenScript: Design optimal peptide antigens:
  • WNK lysine deficient protein kinase 2 (A6PVR2_HUMAN)
  • WNK lysine deficient protein kinase 2 (A6PVR3_HUMAN)
  • WNK lysine deficient protein kinase 2 (A6PVR4_HUMAN)
  • WNK lysine deficient protein kinase 2 (A6PVV2_HUMAN)
  • Serologically defined colon cancer antigen 43 (WNK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3S1

UniProtKB/Swiss-Prot:

WNK2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
genes like me logo Genes that share domains with WNK2: view

Function for WNK2 Gene

Molecular function for WNK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9H4A3};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9H4A3};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity (By similarity).

Enzyme Numbers (IUBMB) for WNK2 Gene

Phenotypes From GWAS Catalog for WNK2 Gene

Gene Ontology (GO) - Molecular Function for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005524 ATP binding IEA,ISS --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with WNK2: view
genes like me logo Genes that share phenotypes with WNK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WNK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WNK2 Gene

Localization for WNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNK2 Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNK2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 17667937
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with WNK2: view

Pathways & Interactions for WNK2 Gene

genes like me logo Genes that share pathways with WNK2: view

Pathways by source for WNK2 Gene

SIGNOR curated interactions for WNK2 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 21733846
GO:0008285 negative regulation of cell proliferation IMP 17667937
GO:0010766 negative regulation of sodium ion transport IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0032414 positive regulation of ion transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with WNK2: view

Drugs & Compounds for WNK2 Gene

(2) Drugs for WNK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for WNK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with WNK2: view

Transcripts for WNK2 Gene

mRNA/cDNA for WNK2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNK2

Alternative Splicing Database (ASD) splice patterns (SP) for WNK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - -
SP3: -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32a · 32b ^ 33 ^ 34 ^ 35
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: - - - -
SP9: - - -
SP10: -
SP11: - -
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WNK2 Gene

GeneLoc Exon Structure for
WNK2

Expression for WNK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.4) and Heart - Left Ventricle (x4.8).

Protein differential expression in normal tissues from HIPED for WNK2 Gene

This gene is overexpressed in Retina (14.5), Frontal cortex (8.2), Spleen (8.1), Pancreas (7.1), and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WNK2 Gene



Protein tissue co-expression partners for WNK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNK2

SOURCE GeneReport for Unigene cluster for WNK2 Gene:

Hs.654856

mRNA Expression by UniProt/SwissProt for WNK2 Gene:

Q9Y3S1-WNK2_HUMAN
Tissue specificity: Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.

Evidence on tissue expression from TISSUES for WNK2 Gene

  • Nervous system(4.5)
  • Heart(2.5)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with WNK2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNK2 Gene

Orthologs for WNK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WNK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WNK2 30
  • 97.75 (n)
Mouse
(Mus musculus)
Mammalia Wnk2 30 17 31
  • 84.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnk2 30
  • 84.38 (n)
Cow
(Bos Taurus)
Mammalia WNK2 30 31
  • 82.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WNK2 30 31
  • 81.8 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WNK2 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WNK2 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WNK2 30 31
  • 66.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WNK2 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wnk2 30
  • 65.74 (n)
Zebrafish
(Danio rerio)
Actinopterygii WNK2 31
  • 34 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2383 30
Fruit Fly
(Drosophila melanogaster)
Insecta Wnk 31
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea wnk-1 31
  • 25 (a)
OneToMany
Barley
(Hordeum vulgare)
Liliopsida Hv.2463 30
Rice
(Oryza sativa)
Liliopsida Os.2221 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
OneToMany
Species where no ortholog for WNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WNK2 Gene

ENSEMBL:
Gene Tree for WNK2 (if available)
TreeFam:
Gene Tree for WNK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNK2: view image

Paralogs for WNK2 Gene

Paralogs for WNK2 Gene

(7) SIMAP similar genes for WNK2 Gene using alignment to 11 proteins:

  • WNK2_HUMAN
  • A6PVV2_HUMAN
  • A8MQ23_HUMAN
  • C9JGD6_HUMAN
  • E9PCD1_HUMAN
  • F8W7S2_HUMAN
  • F8W9F9_HUMAN
  • H0Y493_HUMAN
  • H0Y7J9_HUMAN
  • H0Y7R3_HUMAN
  • H0Y7T5_HUMAN
genes like me logo Genes that share paralogs with WNK2: view

Variants for WNK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNK2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
711710 Likely Benign: not provided 93,293,010(+) C/T MISSENSE_VARIANT
771731 Likely Benign: not provided 93,257,029(+) C/A MISSENSE_VARIANT
776434 Benign: not provided 93,259,271(+) G/C MISSENSE_VARIANT
778435 Benign: not provided 93,256,461(+) G/A INTRON_VARIANT
780820 Benign: not provided 93,234,799(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for WNK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WNK2 Gene

Variant ID Type Subtype PubMed ID
esv1441694 CNV insertion 17803354
esv1576972 CNV insertion 17803354
esv2506086 CNV insertion 19546169
esv2668317 CNV deletion 23128226
esv2738781 CNV deletion 23290073
esv2738782 CNV deletion 23290073
esv3310587 CNV novel sequence insertion 20981092
esv3331340 CNV duplication 20981092
nsv1117518 CNV tandem duplication 24896259
nsv1117519 CNV tandem duplication 24896259
nsv1129825 CNV tandem duplication 24896259
nsv1137482 CNV deletion 24896259
nsv1161884 CNV deletion 26073780
nsv1161885 CNV duplication 26073780
nsv415527 CNV deletion 16902084
nsv415569 CNV deletion 16902084
nsv415836 CNV deletion 16902084
nsv509310 CNV insertion 20534489
nsv526296 CNV loss 19592680
nsv614880 CNV loss 21841781
nsv824983 CNV gain 20364138
nsv950897 CNV deletion 24416366
nsv950898 CNV deletion 24416366

Variation tolerance for WNK2 Gene

Gene Damage Index Score: 12.28; 94.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNK2 Gene

Human Gene Mutation Database (HGMD)
WNK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNK2 Gene

Disorders for WNK2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for WNK2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search WNK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNK2 Gene

Publications for WNK2 Gene

  1. WNK2 modulates MEK1 activity through the Rho GTPase pathway. (PMID: 18593598) Moniz S … Jordan P (Cellular signalling 2008) 3 4 23
  2. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. (PMID: 11571656) Veríssimo F … Jordan P (Oncogene 2001) 2 3 4
  3. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. (PMID: 21733846) Rinehart J … Lifton RP (The Journal of biological chemistry 2011) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41

Products for WNK2 Gene

Sources for WNK2 Gene