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Aliases for WLS Gene
Aliases for WLS Gene
External Ids for WLS Gene
- HGNC: 30238
- Entrez Gene: 79971
- Ensembl: ENSG00000116729
- OMIM: 611514
- UniProtKB: Q5T9L3
Previous HGNC Symbols for WLS Gene
- C1orf139
- GPR177
Previous GeneCards Identifiers for WLS Gene
- GC01M068564
- GC01M066674
Summaries for WLS Gene
GeneCards Summary for WLS Gene
WLS (Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Mental Retardation With Language Impairment And With Or Without Autistic Features and Focal Dermal Hypoplasia. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and mu-type opioid receptor binding.
UniProtKB/Swiss-Prot Summary for WLS Gene
-
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Additional gene information for WLS Gene
- HGNC(30238)
- Entrez Gene(79971)
- Ensembl(ENSG00000116729)
- OMIM(611514)
- UniProtKB(Q5T9L3)
- Open Targets Platform(ENSG00000116729)
- Search for WLS at DataMed
- Search for WLS at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WLS Gene
Genomics for WLS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WLS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WLS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WLS
Genomic Locations for WLS Gene
Genomic Locations for WLS Gene
- chr1:68,098,459-68,233,120
- (GRCh38/hg38)
- Size:
- 134,662 bases
- Orientation:
- Minus strand
- chr1:68,564,142-68,698,803
- (GRCh37/hg19)
- Size:
- 134,662 bases
- Orientation:
- Minus strand
Genomic View for WLS Gene
Genes around WLS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
WLS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WLS Gene
Proteins for WLS Gene
-
Protein details for WLS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T9L3-WLS_HUMAN
- Recommended name:
- Protein wntless homolog
- Protein Accession:
- Q5T9L3
- B2RNT2
- Q5JRS7
- Q7Z2Z9
- Q8NC43
Protein attributes for WLS Gene
- Size:
- 541 amino acids
- Molecular mass:
- 62253 Da
- Quaternary structure:
-
- Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity).
Protein Expression for WLS Gene
Post-translational modifications for WLS Gene
- N-glycosylated.
-
Ubiquitination at Lys73, Lys217, and Lys419
- NX_Q5T9L3 (NX_Q5T9L3-1)
- Modification sites at PhosphoSitePlus
Other Protein References for WLS Gene
Antibody Products
- BioLegend Wntless (GPR177) Antibody
- Novus Biologicals Antibodies for WLS
-
Abcam antibodies for WLS
- Invitrogen Antibodies for WLS (AFLGC-WLS)
Protein Products
-
OriGene Purified Proteins for WLS
- Search Origene for MassSpec and Protein Over-expression Lysates for WLS
- Origene Custom Protein Services for WLS
- Novus Biologicals proteins for WLS
- ProSpec Recombinant Proteins for WLS
- antibodies-online: Show 5 available WLS Proteins ranked by validation data
- Compare Top WLS Proteins
-
Quality Products:
-
Abcam proteins for WLS
No data available for DME Specific Peptides for WLS Gene
Domains & Families for WLS Gene
Gene Families for WLS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for WLS Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ90102 fis, clone HEMBA1006299, highly similar to Putative NFkB activating protein 373 (Q8N2N3_HUMAN)
- GPR177 protein (Q96IV8_HUMAN)
- Putative NF-kappa-B-activating protein 373 (WLS_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5T9L3- Family:
-
- Belongs to the wntless family.
Function for WLS Gene
Molecular function for WLS Gene
- UniProtKB/Swiss-Prot Function:
- Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Phenotypes From GWAS Catalog for WLS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18160348 |
| GO:0017147 | Wnt-protein binding | IEA,ISS | 16678095 |
| GO:0031852 | mu-type opioid receptor binding | IEA | -- |
Phenotypes for WLS Gene
- MGI mutant phenotypes for WLS:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for WLS:
Animal Models for WLS Gene
- MGI Knock Outs for WLS:
-
- Wls Wls<tm1.2Whsu>
Animal Model Products
-
Taconic Biosciences Mouse Models for WLS
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WLS - Select products 50% OFF >
- * WLS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WLS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WLS
-
Santa Cruz Biotechnology (SCBT) CRISPR for WLS
miRNA for WLS Gene
- miRTarBase miRNAs that target WLS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WLS
- Browse OriGene Inhibitory RNA Products For WLS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WLS
Clone Products
- Applied Biological Materials (abm): Clones for WLS - Select products 50% OFF >
- * WLS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207034
- MG208639
- MR207034
- MR207034L3
- MR207034L4
- MR208639
- MR208639L3
- MR208639L4
- RC211072
- RC211072L1
- RC211072L2
- RC211072L3
- RC211072L4
- RC216072
- RC216072L3
- RC216072L4
- RC231242
- RC231242L3
- RC231242L4
- RG211072
- RG216072
- RG231242
- RR200060
- RR200060L3
- RR200060L4
- RR216879
- MR207034L3V
- MR207034L4V
- MR208639L3V
- MR208639L4V
- RC211072L1V
- RC211072L2V
- RC211072L3V
- RC211072L4V
- RC216072L3V
- RC216072L4V
- RC231242L3V
- RC231242L4V
- RR200060L3V
- RR200060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for WLS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WLS
Cell Line Products
-
Horizon Cell Lines for WLS
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WLS Gene
Localization for WLS Gene
Subcellular locations from UniProtKB/Swiss-Prot for WLS Gene
- Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Early endosome membrane. Multi-pass membrane protein. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269 PubMed:18160347}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| endosome | 4 |
| cytosol | 4 |
| golgi apparatus | 4 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IDA | 18160348 |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
Pathways & Interactions for WLS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Signaling by Wnt |
.71
|
|
| 3 | WNT ligand biogenesis and trafficking | ||
Pathways by source for WLS Gene
3 Reactome pathways for WLS Gene
Interacting Proteins for WLS Gene
Selected Interacting proteins:
Q5T9L3-WLS_HUMAN
ENSP00000346829
for WLS Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for WLS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001707 | mesoderm formation | IEA | -- |
| GO:0006886 | intracellular protein transport | IMP | 16678095 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009948 | anterior/posterior axis specification | ISS | -- |
| GO:0016055 | Wnt signaling pathway | IEA,TAS | -- |
Transcripts for WLS Gene
mRNA/cDNA for WLS Gene
- 3 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262348 2716 nts (view in UCSC)
- ENST00000354777 2037 nts (view in UCSC)
- ENST00000370971 700 nts (view in UCSC)
- ENST00000370973 572 nts (view in UCSC)
- ENST00000370976 2332 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WLS - Select products 50% OFF >
- * WLS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WLS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WLS
-
Santa Cruz Biotechnology (SCBT) CRISPR for WLS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WLS
- Browse OriGene Inhibitory RNA Products For WLS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WLS
Clone Products
- Applied Biological Materials (abm): Clones for WLS - Select products 50% OFF >
- * WLS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207034
- MG208639
- MR207034
- MR207034L3
- MR207034L4
- MR208639
- MR208639L3
- MR208639L4
- RC211072
- RC211072L1
- RC211072L2
- RC211072L3
- RC211072L4
- RC216072
- RC216072L3
- RC216072L4
- RC231242
- RC231242L3
- RC231242L4
- RG211072
- RG216072
- RG231242
- RR200060
- RR200060L3
- RR200060L4
- RR216879
- MR207034L3V
- MR207034L4V
- MR208639L3V
- MR208639L4V
- RC211072L1V
- RC211072L2V
- RC211072L3V
- RC211072L4V
- RC216072L3V
- RC216072L4V
- RC231242L3V
- RC231242L4V
- RR200060L3V
- RR200060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for WLS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WLS
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for WLS Gene
- GeneLoc Exon Structure for
- WLS
Expression for WLS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- NULL (Uncategorized)
-
Hair (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Dermis (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
-
Eye (Sensory Organs)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Neural Ectoderm (Nervous System)
- Endoderm (Gastrulation Derivatives)
- Heart (Cardiovascular System)
- Neural Tube (Nervous System)
This gene is overexpressed in Ovary (16.0) and Lung (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WLS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WLS
SOURCE GeneReport for Unigene cluster for WLS Gene:
Hs.647659Evidence on tissue expression from TISSUES for WLS Gene
- Nervous system(5)
- Lung(4.6)
- Kidney(3.6)
- Skin(3.1)
- Intestine(2.8)
- Muscle(2.7)
- Heart(2.7)
- Stomach(2.4)
- Eye(2.3)
- Blood(2.1)
- Pancreas(2.1)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for WLS
-
OriGene qPCR primer pairs and template standards for WLS
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WLS Gene
Orthologs for WLS Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WLS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WLS 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wls 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Wls 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WLS 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | WLS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WLS 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WLS 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WLS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wls 30 |
|
||
| Str.1995 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11487 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wls 30 31 |
|
OneToOne | |
| idibd2010 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12186 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007896 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | wls 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mig-14 30 31 |
|
OneToOne |
- Species where no ortholog for WLS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WLS Gene
- ENSEMBL:
- Gene Tree for WLS (if available)
- TreeFam:
- Gene Tree for WLS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WLS: view image
Paralogs for WLS Gene
(1) SIMAP similar genes for WLS Gene using alignment to 11 proteins:
- WLS_HUMAN
- E9PJW4_HUMAN
- E9PKJ0_HUMAN
- E9PM23_HUMAN
- E9PM62_HUMAN
- E9PQK1_HUMAN
- F5H4K0_HUMAN
- H0YCG9_HUMAN
- H0YDL2_HUMAN
- L8E8F2_HUMAN
- Q7Z430_HUMAN
No data available for Paralogs for WLS Gene
Variants for WLS Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2672790 | CNV | deletion | 23128226 |
| esv2749463 | CNV | deletion | 23290073 |
| esv2749475 | CNV | deletion | 23290073 |
| esv3563538 | CNV | deletion | 23714750 |
| esv3577910 | CNV | loss | 25503493 |
| nsv1078488 | CNV | deletion | 25765185 |
| nsv477165 | CNV | novel sequence insertion | 20440878 |
| nsv517355 | CNV | gain+loss | 19592680 |
| nsv518820 | CNV | loss | 19592680 |
| nsv522414 | CNV | loss | 19592680 |
| nsv522557 | CNV | loss | 19592680 |
| nsv546448 | CNV | gain | 21841781 |
| nsv945987 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.74;
86.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WLS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WLS
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WLS Gene
Disorders for WLS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation with language impairment and with or without autistic features |
|
|
| focal dermal hypoplasia |
|
|
| sting-associated vasculopathy with onset in infancy |
|
|
| osteoporosis |
|
|
Search WLS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WLS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for WLS Gene
Publications for WLS Gene
- Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. (PMID: 20652957) Jin J … Levenson R (Developmental dynamics : an official publication of the American Association of Anatomists 2010) 2 3 4
- Motoneuron Wnts regulate neuromuscular junction development. (PMID: 30113308) Shen C … Mei L (eLife 2018) 2 3
- Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PMID: 16678095) Bänziger C … Basler K (Cell 2006) 3 4
ExternalLinks
Products for WLS Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for WLS
- Search Origene for MassSpec and Protein Over-expression Lysates for WLS
- Origene Custom Protein Services for WLS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WLS
- Browse OriGene Inhibitory RNA Products For WLS
- OriGene qPCR primer pairs for WLS
- OriGene qPCR primer pairs and template standards for WLS
- OriGene CRISPR knockouts for WLS
- MG207034
- MG208639
- MR207034
- MR207034L3
- MR207034L4
- MR208639
- MR208639L3
- MR208639L4
- RC211072
- RC211072L1
- RC211072L2
- RC211072L3
- RC211072L4
- RC216072
- RC216072L3
- RC216072L4
- RC231242
- RC231242L3
- RC231242L4
- RG211072
- RG216072
- RG231242
- RR200060
- RR200060L3
- RR200060L4
- RR216879
- MR207034L3V
- MR207034L4V
- MR208639L3V
- MR208639L4V
- RC211072L1V
- RC211072L2V
- RC211072L3V
- RC211072L4V
- RC216072L3V
- RC216072L4V
- RC231242L3V
- RC231242L4V
- RR200060L3V
- RR200060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 4 available WLS Antibodies ranked by validation data
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- antibodies-online: Show 5 available WLS Proteins ranked by validation data
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Sources for WLS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (115) NCBI Bookshelf
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB