WLS Gene (Protein Coding)

Wnt Ligand Secretion Mediator

GC01M068098
GIFtS:
38

Aliases for WLS Gene

Aliases for WLS Gene

  • Wnt Ligand Secretion Mediator 2 3 5
  • Putative NF-Kappa-B-Activating Protein 373 3 4
  • Wntless Wnt Ligand Secretion Mediator 2 3
  • Protein Evenness Interrupted Homolog 3 4
  • Integral Membrane Protein GPR177 3 4
  • G Protein-Coupled Receptor 177 2 3
  • Protein Wntless Homolog 3 4
  • C1orf139 3 4
  • GPR177 3 4
  • EVI 3 4
  • Putative NFkB Activating Protein 373 3
  • Chromosome 1 Open Reading Frame 139 2
  • Wntless Homolog (Drosophila) 2
  • Wntless Homolog 2
  • Mig-14 3
  • MRP 3

External Ids for WLS Gene

Previous HGNC Symbols for WLS Gene

  • C1orf139
  • GPR177

Previous GeneCards Identifiers for WLS Gene

  • GC01M068564
  • GC01M066674

Summaries for WLS Gene

GeneCards Summary for WLS Gene

WLS (Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Focal Dermal Hypoplasia and Acute Hemorrhagic Conjunctivitis. Among its related pathways are Signaling by Wnt and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and mu-type opioid receptor binding.

UniProtKB/Swiss-Prot Summary for WLS Gene

  • Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Wiki entry for WLS Gene

Additional gene information for WLS Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WLS Gene

Genomics for WLS Gene

GeneHancer (GH) Regulatory Elements for WLS Gene

Promoters and enhancers for WLS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J068228 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.4 +2.1 2119 4.8 USF1 ZNF10 ZIC2 ZBTB10 POLR2A ZNF423 GABPA ZBTB26 KLF7 HDAC2 WLS MIR1262
GH01J068196 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.1 +34.8 34819 4.2 TCF12 FOXA2 BCL11A ZNF316 MAFF ZNF184 FOS FOSL2 MAFK CEBPB WLS GNG12-AS1 MIR1262
GH01J068172 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.2 +56.7 56680 7.6 EP300 ZSCAN5C JUND FOS ZIC2 REST TRIM28 RFX1 ZNF341 OSR2 WLS RPE65 IL12RB2 piR-38352-008 MIR1262 GNG12-AS1
GH01J068269 Enhancer 0.7 Ensembl ENCODE 14.8 -36.9 -36881 5.2 TEAD4 FOS CEBPB JUN SPI1 RCOR1 JUND HIC1 ZFP37 BHLHE40 lnc-GADD45A-8 WLS MIR1262 COX6B1P7
GH01J068253 Enhancer 0.5 Ensembl 20 -22.7 -22681 3.6 USF1 FOS CEBPG CEBPB NFE2 EP300 HLF STAT3 WLS MIR1262 RPS7P4 lnc-GADD45A-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WLS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WLS

Genomic Locations for WLS Gene

Genomic Locations for WLS Gene
chr1:68,098,459-68,233,120
(GRCh38/hg38)
Size:
134,662 bases
Orientation:
Minus strand
chr1:68,564,142-68,698,803
(GRCh37/hg19)
Size:
134,662 bases
Orientation:
Minus strand

Genomic View for WLS Gene

Genes around WLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WLS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WLS Gene

Proteins for WLS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9L3-WLS_HUMAN
    Recommended name:
    Protein wntless homolog
    Protein Accession:
    Q5T9L3
    Secondary Accessions:
    • B2RNT2
    • Q5JRS7
    • Q7Z2Z9
    • Q8NC43

    Protein attributes for WLS Gene

    Size:
    541 amino acids
    Molecular mass:
    62253 Da
    Quaternary structure:
    • Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity).

    Alternative splice isoforms for WLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WLS Gene

Protein Expression for WLS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WLS Gene

  • Ubiquitination at Lys73, Lys217, and Lys419
  • Modification sites at PhosphoSitePlus

Other Protein References for WLS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WLS Gene

Domains & Families for WLS Gene

Gene Families for WLS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for WLS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WLS Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ90102 fis, clone HEMBA1006299, highly similar to Putative NFkB activating protein 373 (Q8N2N3_HUMAN)
  • GPR177 protein (Q96IV8_HUMAN)
  • Putative NF-kappa-B-activating protein 373 (WLS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T9L3

UniProtKB/Swiss-Prot:

WLS_HUMAN :
  • Belongs to the wntless family.
Family:
  • Belongs to the wntless family.
genes like me logo Genes that share domains with WLS: view

Function for WLS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for WLS Gene

UniProtKB/Swiss-Prot Function:
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Phenotypes From GWAS Catalog for WLS Gene

Gene Ontology (GO) - Molecular Function for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18160348
GO:0017147 Wnt-protein binding ISS,IEA 16678095
GO:0031852 mu-type opioid receptor binding IEA --
genes like me logo Genes that share ontologies with WLS: view
genes like me logo Genes that share phenotypes with WLS: view

Animal Models for WLS Gene

MGI Knock Outs for WLS:
  • Wls Wls<tm1.2Whsu>

Animal Model Products

  • Taconic Biosciences Mouse Models for WLS

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WLS Gene

Localization for WLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for WLS Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269 PubMed:18160347}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WLS gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 4
endosome 4
cytosol 4
golgi apparatus 4
nucleus 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 18160348
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with WLS: view

Pathways & Interactions for WLS Gene

genes like me logo Genes that share pathways with WLS: view

Pathways by source for WLS Gene

SIGNOR curated interactions for WLS Gene

Activates:

Gene Ontology (GO) - Biological Process for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0006886 intracellular protein transport IMP 16678095
GO:0007275 multicellular organism development IEA --
GO:0009948 anterior/posterior axis specification ISS --
GO:0016055 Wnt signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with WLS: view

Drugs & Compounds for WLS Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WLS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for WLS Gene

3 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WLS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for WLS Gene

GeneLoc Exon Structure for
WLS

Expression for WLS Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WLS Gene

mRNA expression in normal human tissues for WLS Gene
mRNA expression by BioGPS for WLS GenemRNA expression by GTEx for WLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WLS Gene

This gene is overexpressed in Ovary (16.0) and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WLS Gene



Protein tissue co-expression partners for WLS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WLS

SOURCE GeneReport for Unigene cluster for WLS Gene:

Hs.647659

Evidence on tissue expression from TISSUES for WLS Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Kidney(3.2)
  • Heart(2.4)
  • Muscle(2.4)
  • Intestine(2.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with WLS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WLS Gene

Orthologs for WLS Gene

This gene was present in the common ancestor of animals.

Orthologs for WLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia WLS 31 30
  • 99.19 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia WLS 31 30
  • 93.04 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Wls 30
  • 89.71 (n)
mouse
(Mus musculus)
 Mammalia Wls 17 31 30
  • 89.65 (n)
dog
(Canis familiaris)
 Mammalia WLS 31 30
  • 89.03 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia WLS 31
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia WLS 31
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves WLS 31 30
  • 79.85 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia WLS 31
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia wls 30
  • 71.35 (n)
Str.1995 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.11487 30
zebrafish
(Danio rerio)
 Actinopterygii wls 31 30
  • 74.43 (n)
 OneToOne
idibd2010 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12186 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007896 30
  • 55.47 (n)
fruit fly
(Drosophila melanogaster)
 Insecta wls 31 30
  • 53.26 (n)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea mig-14 31 30
  • 51.08 (n)
 OneToOne
Species where no ortholog for WLS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WLS Gene

ENSEMBL:
Gene Tree for WLS (if available)
TreeFam:
Gene Tree for WLS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WLS: view image

Paralogs for WLS Gene

(1) SIMAP similar genes for WLS Gene using alignment to 11 proteins:

  • WLS_HUMAN
  • E9PJW4_HUMAN
  • E9PKJ0_HUMAN
  • E9PM23_HUMAN
  • E9PM62_HUMAN
  • E9PQK1_HUMAN
  • F5H4K0_HUMAN
  • H0YCG9_HUMAN
  • H0YDL2_HUMAN
  • L8E8F2_HUMAN
  • Q7Z430_HUMAN
genes like me logo Genes that share paralogs with WLS: view

No data available for Paralogs for WLS Gene

Variants for WLS Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WLS Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs983034 - p.Val465Ile

Additional dbSNP identifiers (rs#s) for WLS Gene

Structural Variations from Database of Genomic Variants (DGV) for WLS Gene

Variant ID Type Subtype PubMed ID
esv2672790 CNV deletion 23128226
esv2749463 CNV deletion 23290073
esv2749475 CNV deletion 23290073
esv3563538 CNV deletion 23714750
esv3577910 CNV loss 25503493
nsv1078488 CNV deletion 25765185
nsv477165 CNV novel sequence insertion 20440878
nsv517355 CNV gain+loss 19592680
nsv518820 CNV loss 19592680
nsv522414 CNV loss 19592680
nsv522557 CNV loss 19592680
nsv546448 CNV gain 21841781
nsv945987 CNV duplication 23825009

Variation tolerance for WLS Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WLS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WLS Gene

Disorders for WLS Gene

MalaCards: The human disease database

(3) MalaCards diseases for WLS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
focal dermal hypoplasia
  • fdh
acute hemorrhagic conjunctivitis
  • apollo disease
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
- elite association - COSMIC cancer census association via MalaCards
Search WLS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WLS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WLS Gene

Publications for WLS Gene

  1. Motoneuron Wnts regulate neuromuscular junction development. (PMID: 30113308) Shen C … Mei L (eLife 2018) 2 3 54
  2. Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. (PMID: 20652957) Jin J … Levenson R (Developmental dynamics : an official publication of the American Association of Anatomists 2010) 2 3 54
  3. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 3 41 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PMID: 16678095) Bänziger C … Basler K (Cell 2006) 3 4 54

ExternalLinks

View latest publications for WLS gene in Mastermind

Products for WLS Gene

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