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WLS (Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Mental Retardation With Language Impairment And With Or Without Autistic Features and Focal Dermal Hypoplasia. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and mu-type opioid receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18160348 |
GO:0017147 | Wnt-protein binding | IEA,ISS | 16678095 |
GO:0031852 | mu-type opioid receptor binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IDA | 18160348 |
GO:0005783 | endoplasmic reticulum | IDA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Signaling by Wnt |
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3 | WNT ligand biogenesis and trafficking |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001707 | mesoderm formation | IEA | -- |
GO:0006886 | intracellular protein transport | IMP | 16678095 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0009948 | anterior/posterior axis specification | ISS | -- |
GO:0016055 | Wnt signaling pathway | IEA,TAS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
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SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WLS 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | WLS 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wls 30 |
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||
Mouse (Mus musculus) |
Mammalia | Wls 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WLS 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | WLS 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WLS 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | WLS 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WLS 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wls 30 |
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Str.1995 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.11487 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | wls 30 31 |
|
OneToOne | |
idibd2010 30 |
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Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12186 30 |
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||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007896 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | wls 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | mig-14 30 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2672790 | CNV | deletion | 23128226 |
esv2749463 | CNV | deletion | 23290073 |
esv2749475 | CNV | deletion | 23290073 |
esv3563538 | CNV | deletion | 23714750 |
esv3577910 | CNV | loss | 25503493 |
nsv1078488 | CNV | deletion | 25765185 |
nsv477165 | CNV | novel sequence insertion | 20440878 |
nsv517355 | CNV | gain+loss | 19592680 |
nsv518820 | CNV | loss | 19592680 |
nsv522414 | CNV | loss | 19592680 |
nsv522557 | CNV | loss | 19592680 |
nsv546448 | CNV | gain | 21841781 |
nsv945987 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mental retardation with language impairment and with or without autistic features |
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focal dermal hypoplasia |
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sting-associated vasculopathy with onset in infancy |
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osteoporosis |
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