Aliases for WIZ Gene

Aliases for WIZ Gene

  • WIZ Zinc Finger 2 3 5
  • ZNF803 2 3 4
  • Widely-Interspaced Zinc Finger-Containing Protein 3 4
  • Widely Interspaced Zinc Finger Motifs 2 3
  • Zinc Finger Protein 803 3 4
  • Protein Wiz 3 4
  • WIZ 5

External Ids for WIZ Gene

Previous GeneCards Identifiers for WIZ Gene

  • GC19M015911
  • GC19M015377
  • GC19M015394
  • GC19M015395
  • GC19M015397
  • GC19M015532
  • GC19M015100

Summaries for WIZ Gene

GeneCards Summary for WIZ Gene

WIZ (WIZ Zinc Finger) is a Protein Coding gene. Diseases associated with WIZ include Johanson-Blizzard Syndrome and Exstrophy Of Bladder. Gene Ontology (GO) annotations related to this gene include SET domain binding. An important paralog of this gene is ZNF592.

UniProtKB/Swiss-Prot Summary for WIZ Gene

  • May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

Additional gene information for WIZ Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WIZ Gene

Genomics for WIZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WIZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WIZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WIZ

Top Transcription factor binding sites by QIAGEN in the WIZ gene promoter:
  • AREB6
  • CP2
  • GR
  • GR-alpha
  • GR-beta
  • HTF
  • RSRFC4
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for WIZ Gene

Genomic Locations for WIZ Gene
chr19:15,419,978-15,449,956
(GRCh38/hg38)
Size:
29,979 bases
Orientation:
Minus strand
chr19:15,532,318-15,560,762
(GRCh37/hg19)
Size:
28,445 bases
Orientation:
Minus strand

Genomic View for WIZ Gene

Genes around WIZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIZ Gene

Proteins for WIZ Gene

  • Protein details for WIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95785-WIZ_HUMAN
    Recommended name:
    Protein Wiz
    Protein Accession:
    O95785
    Secondary Accessions:
    • B3KVH1
    • B7ZM82
    • M0QY21
    • Q4G0E0
    • Q6P6B0
    • Q6ZN24
    • Q7LDY6
    • Q7LDZ1
    • Q96IG5
    • Q96SQ6
    • Q9BUR8
    • Q9NPT1

    Protein attributes for WIZ Gene

    Size:
    1651 amino acids
    Molecular mass:
    178674 Da
    Quaternary structure:
    • Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
    SequenceCaution:
    • Sequence=BAB55234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for WIZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIZ Gene

Post-translational modifications for WIZ Gene

  • Ubiquitination at Lys1597
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WIZ Gene

Domains & Families for WIZ Gene

Gene Families for WIZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for WIZ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WIZ Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16541 fis, clone OCBBF2034823, highly similar to Mus musculus widely-interspaced zinc finger motifs (Wiz), transcript variant 1, mRNA (B3KVH1_HUMAN)
  • WIZ protein (B7ZM82_HUMAN)
  • WIZ protein (B9EGQ5_HUMAN)
  • Zinc finger protein 803 (WIZ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95785

UniProtKB/Swiss-Prot:

WIZ_HUMAN :
  • The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with WIZ: view

Function for WIZ Gene

Molecular function for WIZ Gene

UniProtKB/Swiss-Prot Function:
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

Phenotypes From GWAS Catalog for WIZ Gene

Gene Ontology (GO) - Molecular Function for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 16702210
GO:0044877 protein-containing complex binding IDA 16702210
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WIZ: view
genes like me logo Genes that share phenotypes with WIZ: view

Animal Model Products

CRISPR Products

miRNA for WIZ Gene

miRTarBase miRNAs that target WIZ

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIZ Gene

Localization for WIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIZ Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIZ gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 16702210
GO:0005654 nucleoplasm IDA --
GO:0030496 midbody IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with WIZ: view

Pathways & Interactions for WIZ Gene

PathCards logo

SuperPathways for WIZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 23545495
GO:0050821 protein stabilization IMP 16702210
genes like me logo Genes that share ontologies with WIZ: view

No data available for Pathways by source and SIGNOR curated interactions for WIZ Gene

Drugs & Compounds for WIZ Gene

No Compound Related Data Available

Transcripts for WIZ Gene

mRNA/cDNA for WIZ Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIZ

Alternative Splicing Database (ASD) splice patterns (SP) for WIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for WIZ Gene

GeneLoc Exon Structure for
WIZ

Expression for WIZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WIZ Gene

Protein differential expression in normal tissues from HIPED for WIZ Gene

This gene is overexpressed in Heart (31.9) and Peripheral blood mononuclear cells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WIZ Gene



Protein tissue co-expression partners for WIZ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WIZ

SOURCE GeneReport for Unigene cluster for WIZ Gene:

Hs.442138

Evidence on tissue expression from TISSUES for WIZ Gene

  • Nervous system(4.7)
  • Skin(4.5)
  • Muscle(4.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with WIZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIZ Gene

Orthologs for WIZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIZ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WIZ 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WIZ 30 31
  • 89.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WIZ 30 31
  • 88.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wiz 30
  • 86.79 (n)
Mouse
(Mus musculus)
Mammalia Wiz 30 17 31
  • 86.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WIZ 31
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WIZ 31
  • 30 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WIZ 30
  • 69.68 (n)
Lizard
(Anolis carolinensis)
Reptilia WIZ 31
  • 33 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii WIZ 31
  • 13 (a)
OneToOne
wufi11h08 30
Species where no ortholog for WIZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WIZ Gene

ENSEMBL:
Gene Tree for WIZ (if available)
TreeFam:
Gene Tree for WIZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WIZ: view image

Paralogs for WIZ Gene

Variants for WIZ Gene

Additional dbSNP identifiers (rs#s) for WIZ Gene

Structural Variations from Database of Genomic Variants (DGV) for WIZ Gene

Variant ID Type Subtype PubMed ID
nsv1064684 CNV gain 25217958
nsv1118815 CNV deletion 24896259
nsv819830 CNV gain 19587683
nsv833765 CNV loss 17160897
nsv953987 CNV deletion 24416366

Variation tolerance for WIZ Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIZ Gene

Human Gene Mutation Database (HGMD)
WIZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIZ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WIZ Gene

Disorders for WIZ Gene

MalaCards: The human disease database

(4) MalaCards diseases for WIZ Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search WIZ in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with WIZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIZ Gene

Publications for WIZ Gene

  1. Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. (PMID: 27410475) Isbel L … Whitelaw E (eLife 2016) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. (PMID: 12226707) Baust C … Mager DL (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 2 3
  4. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. (PMID: 9795207) Matsumoto K … Tohyama M (Brain research. Molecular brain research 1998) 2 3
  5. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. (PMID: 31160578) Coulombe P … Méchali M (Nature communications 2019) 3

Products for WIZ Gene

Sources for WIZ Gene