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Aliases for WISP3 Gene

Aliases for WISP3 Gene

  • WNT1 Inducible Signaling Pathway Protein 3 2 3 5
  • CCN Family Member 6 3 4
  • WISP-3 3 4
  • CCN6 3 4
  • WNT1-Inducible-Signaling Pathway Protein 3 3
  • LIBC 3
  • PPAC 3
  • PPD 3

External Ids for WISP3 Gene

Previous GeneCards Identifiers for WISP3 Gene

  • GC06P112210
  • GC06P112398
  • GC06P112420
  • GC06P112481
  • GC06P112375
  • GC06P109950

Summaries for WISP3 Gene

Entrez Gene Summary for WISP3 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WISP3 Gene

WISP3 (WNT1 Inducible Signaling Pathway Protein 3) is a Protein Coding gene. Diseases associated with WISP3 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Arthropathy. Gene Ontology (GO) annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is WISP1.

UniProtKB/Swiss-Prot for WISP3 Gene

  • Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

Gene Wiki entry for WISP3 Gene

Additional gene information for WISP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP3 Gene

Genomics for WISP3 Gene

GeneHancer (GH) Regulatory Elements for WISP3 Gene

Promoters and enhancers for WISP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I112054 Promoter 0.6 EPDnew 574.6 +0.6 569 0.1 CREB1 WISP3 FAM229B
GH06I112086 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.3 +33.9 33885 2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TUBE1 FAM229B WISP3 ENSG00000237234
GH06I112041 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.1 -9.6 -9551 4.4 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 ZNF207 WISP3 ENSG00000255389 FAM229B TRAF3IP2-AS1 TUBE1 FYN TRAF3IP2 GC06M111982
GH06I112036 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -14.9 -14858 4.1 FOXA2 JUN ZIC2 OSR2 E2F1 GATA3 JUND POLR2A ZNF692 ZNF629 WISP3 FAM229B TRAF3IP2 FYN TUBE1 GC06M111982
GH06I112112 Enhancer 0.6 dbSUPER 19.2 +60.6 60555 2.7 FOXA2 JUND RXRA ATF3 HNF4G ZBTB33 HNF4A YY1 WISP3 FAM229B ENSG00000237234 TUBE1 RNU6-1226P LAMA4 LOC100128588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WISP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WISP3 gene promoter:

Genomic Locations for WISP3 Gene

Genomic Locations for WISP3 Gene
17,454 bases
Plus strand

Genomic View for WISP3 Gene

Genes around WISP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WISP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WISP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP3 Gene

Proteins for WISP3 Gene

  • Protein details for WISP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WNT1-inducible-signaling pathway protein 3
    Protein Accession:
    Secondary Accessions:
    • Q3KR29
    • Q5H8W4
    • Q6UXH6

    Protein attributes for WISP3 Gene

    354 amino acids
    Molecular mass:
    39293 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP3 Gene


neXtProt entry for WISP3 Gene

Post-translational modifications for WISP3 Gene

  • Glycosylation at posLast=178178 and posLast=308308
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WISP3 Gene

Domains & Families for WISP3 Gene

Gene Families for WISP3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCN family.
  • Belongs to the CCN family.
genes like me logo Genes that share domains with WISP3: view

Function for WISP3 Gene

Molecular function for WISP3 Gene

GENATLAS Biochemistry:
WNT1 inducible signaling pathway protein 3,connective tissue growth factor family,CCN family (CTGF,IGFBP10,NOU)expressed in adult skeletal muscle,colon,ovary and fetal lung,overexpressed in colon tumors,involved in cell growth and differentiation
UniProtKB/Swiss-Prot Function:
Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

Gene Ontology (GO) - Molecular Function for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with WISP3: view
genes like me logo Genes that share phenotypes with WISP3: view

Human Phenotype Ontology for WISP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WISP3 Gene

MGI Knock Outs for WISP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for WISP3

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for WISP3 Gene

Localization for WISP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WISP3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
nucleus 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space NAS 9843955
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with WISP3: view

Pathways & Interactions for WISP3 Gene

SuperPathways for WISP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 9843955
GO:0007267 cell-cell signaling TAS 9843955
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with WISP3: view

No data available for Pathways by source and SIGNOR curated interactions for WISP3 Gene

Drugs & Compounds for WISP3 Gene

(2) Drugs for WISP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for WISP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WISP3: view

Transcripts for WISP3 Gene

Unigene Clusters for WISP3 Gene

WNT1 inducible signaling pathway protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WISP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - - -

Relevant External Links for WISP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WISP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WISP3 Gene

mRNA differential expression in normal tissues according to GTEx for WISP3 Gene

This gene is overexpressed in Testis (x8.5), Skin - Sun Exposed (Lower leg) (x8.2), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for WISP3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WISP3 Gene

Protein tissue co-expression partners for WISP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WISP3 Gene:


SOURCE GeneReport for Unigene cluster for WISP3 Gene:


mRNA Expression by UniProt/SwissProt for WISP3 Gene:

Tissue specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes.

Evidence on tissue expression from TISSUES for WISP3 Gene

  • Bone marrow(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WISP3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WISP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WISP3 Gene

Orthologs for WISP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WISP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WISP3 33 34
  • 99.1 (n)
(Bos Taurus)
Mammalia WISP3 33 34
  • 87.48 (n)
(Mus musculus)
Mammalia Wisp3 33 16 34
  • 82.39 (n)
(Canis familiaris)
Mammalia WISP3 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Wisp3 33
  • 80.79 (n)
(Monodelphis domestica)
Mammalia WISP3 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia WISP3 34
  • 74 (a)
(Gallus gallus)
Aves WISP3 33 34
  • 70.9 (n)
(Anolis carolinensis)
Reptilia WISP3 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wisp3 33
  • 65.73 (n)
(Danio rerio)
Actinopterygii wisp3 33 34
  • 60.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ccn 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for WISP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP3 Gene

Gene Tree for WISP3 (if available)
Gene Tree for WISP3 (if available)

Paralogs for WISP3 Gene

Paralogs for WISP3 Gene

(6) SIMAP similar genes for WISP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WISP3: view

Variants for WISP3 Gene

Sequence variations from dbSNP and Humsavar for WISP3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs112665393 likely-benign, Progressive pseudorheumatoid dysplasia 112,061,179(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant
rs121908899 pathogenic, Progressive pseudorheumatoid dysplasia 112,064,842(+) G/A 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs121908900 pathogenic, Progressive pseudorheumatoid dysplasia 112,069,548(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, stop_gained
rs121908901 pathogenic, Progressive pseudorheumatoid dysplasia 112,061,098(+) C/A/T coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, stop_gained, synonymous_variant, upstream_transcript_variant
rs121908902 pathogenic, Progressive pseudorheumatoid dysplasia, Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230] 112,061,174(+) T/C coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WISP3 Gene

Variant ID Type Subtype PubMed ID
esv3352560 CNV insertion 20981092
nsv830774 CNV gain 17160897

Variation tolerance for WISP3 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WISP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WISP3 Gene

Disorders for WISP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for WISP3 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthropathy, progressive pseudorheumatoid, of childhood
  • ppac
  • ankylosis of ankle and foot joint
inflammatory breast carcinoma
  • inflammatory carcinoma of breast
plantar fasciitis
  • fasciitis, plantar
wilms tumor 5
  • nephroblastoma
- elite association - COSMIC cancer census association via MalaCards
Search WISP3 in MalaCards View complete list of genes associated with diseases


  • Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. {ECO:0000269 PubMed:10471507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WISP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WISP3: view

No data available for Genatlas for WISP3 Gene

Publications for WISP3 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D … Levine AJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. Expression of WISP3 and RhoC genes at mRNA and protein levels in inflammatory and noninflammatory breast cancer in Tunisian patients. (PMID: 20014943) Marrakchi R … Elgaaied AB (Cancer investigation 2010) 3 22 58
  3. Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. (PMID: 20372786) Davies SR … Jiang WG (International journal of oncology 2010) 3 22 58
  4. Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. (PMID: 20395207) Huang W … Kleer CG (Cancer research 2010) 3 22 58
  5. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B … Brenner H (Carcinogenesis 2010) 3 44 58

Products for WISP3 Gene

Sources for WISP3 Gene

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