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Aliases for WISP1 Gene

Aliases for WISP1 Gene

  • WNT1 Inducible Signaling Pathway Protein 1 2 3 5
  • WISP1 Overlapping Transcript 1 (Non-Protein Coding) 2 3
  • WISP1 3UTR-Associated RNA 1 2 3
  • CCN Family Member 4 3 4
  • CCN4 3 4
  • WNT1-Inducible-Signaling Pathway Protein 1 3
  • WNT1 Induced Secreted Protein 1 3
  • WISP1 Overlapping Transcript 1 2
  • Wnt-1-Induced Secreted Protein 4
  • WISP1-OT1 3
  • WISP1-UT1 3
  • WISP1tc 3
  • WISP1c 3
  • WISP1i 3
  • WISP-1 4

External Ids for WISP1 Gene

Previous HGNC Symbols for WISP1 Gene

  • WISP1-OT1
  • WISP1-UT1

Previous GeneCards Identifiers for WISP1 Gene

  • GC08P132932
  • GC08P134290
  • GC08P133874
  • GC08P134159
  • GC08P134272
  • GC08P134203
  • GC08P129523

Summaries for WISP1 Gene

Entrez Gene Summary for WISP1 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for WISP1 Gene

WISP1 (WNT1 Inducible Signaling Pathway Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is CTGF.

UniProtKB/Swiss-Prot for WISP1 Gene

  • Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Gene Wiki entry for WISP1 Gene

Additional gene information for WISP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP1 Gene

Genomics for WISP1 Gene

GeneHancer (GH) Regulatory Elements for WISP1 Gene

Promoters and enhancers for WISP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I133190 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 557.2 +0.9 862 2.6 ZFHX2 NR2F2 EGR2 WISP1 GC08P133196
GH08I133051 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.3 -126.3 -126345 25.8 CTCF PKNOX1 USF1 MAX BATF IRF4 RAD21 GATA3 POLR2A ZNF143 SLA TG WISP1 TMEM71 PHF20L1 ENSG00000270137 GC08P133054 GC08P133070
GH08I133128 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -61.1 -61130 3.4 ELF3 ZNF792 CEBPG ZNF644 RAD21 POLR2A VEZF1 RCOR1 FOSL2 FOS WISP1 TG SLA ST3GAL1 PHF20L1 NDRG1 GC08P133116 LOC105375769
GH08I133080 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -108.9 -108885 3.2 CTCF RXRA POLR2A CEBPG RAD21 NR2F2 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08I133147 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 17.8 -43.8 -43798 1.7 ZBTB21 CREB1 ATF7 RUNX3 ATF2 TMEM71 PHF20L1 WISP1 SLA TG ST3GAL1 LOC105375769 GC08M133177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WISP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WISP1 gene promoter:

Genomic Locations for WISP1 Gene

Genomic Locations for WISP1 Gene
chr8:133,191,039-133,231,690
(GRCh38/hg38)
Size:
40,652 bases
Orientation:
Plus strand
chr8:134,203,282-134,243,933
(GRCh37/hg19)

Genomic View for WISP1 Gene

Genes around WISP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WISP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP1 Gene

Proteins for WISP1 Gene

  • Protein details for WISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95388-WISP1_HUMAN
    Recommended name:
    WNT1-inducible-signaling pathway protein 1
    Protein Accession:
    O95388
    Secondary Accessions:
    • A8KAG6
    • E7EMM5
    • Q5JBS6
    • Q5JBS7
    • Q5JBS8
    • Q9HCS3

    Protein attributes for WISP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    40331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WISP1 Gene

Post-translational modifications for WISP1 Gene

  • Glycosylation at posLast=8686, posLast=143143, isoforms=2, 3, 5284, and isoforms=2, 3, 5343
  • Modification sites at PhosphoSitePlus

Other Protein References for WISP1 Gene

Protein Products

  • Abcam proteins for WISP1

No data available for DME Specific Peptides for WISP1 Gene

Domains & Families for WISP1 Gene

Gene Families for WISP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

O95388

UniProtKB/Swiss-Prot:

WISP1_HUMAN :
  • Belongs to the CCN family.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with WISP1: view

Function for WISP1 Gene

Molecular function for WISP1 Gene

GENATLAS Biochemistry:
WNT1 inducible signaling pathway protein 1,connective tissue growth factor family,expressed in adult heart,kidney,lung,pancreas,placenta,ovary,small intestine and spleen,overexpressed in colon tumors
UniProtKB/Swiss-Prot Function:
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Phenotypes From GWAS Catalog for WISP1 Gene

Gene Ontology (GO) - Molecular Function for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with WISP1: view
genes like me logo Genes that share phenotypes with WISP1: view

Animal Models for WISP1 Gene

MGI Knock Outs for WISP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WISP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WISP1 Gene

Localization for WISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WISP1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 3
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space NAS 9843955
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with WISP1: view

Pathways & Interactions for WISP1 Gene

SuperPathways for WISP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 9843955
GO:0007267 cell-cell signaling TAS 9843955
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with WISP1: view

No data available for Pathways by source and SIGNOR curated interactions for WISP1 Gene

Drugs & Compounds for WISP1 Gene

(1) Drugs for WISP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with WISP1: view

Transcripts for WISP1 Gene

Unigene Clusters for WISP1 Gene

WNT1 inducible signaling pathway protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WISP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for WISP1 Gene

GeneLoc Exon Structure for
WISP1
ECgene alternative splicing isoforms for
WISP1

Expression for WISP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WISP1 Gene

Protein differential expression in normal tissues from HIPED for WISP1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WISP1 Gene



Protein tissue co-expression partners for WISP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WISP1 Gene:

WISP1

SOURCE GeneReport for Unigene cluster for WISP1 Gene:

Hs.492974

mRNA Expression by UniProt/SwissProt for WISP1 Gene:

O95388-WISP1_HUMAN
Tissue specificity: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

Evidence on tissue expression from TISSUES for WISP1 Gene

  • Lung(4.4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with WISP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WISP1 Gene

Orthologs for WISP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WISP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WISP1 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia WISP1 33 34
  • 86.1 (n)
cow
(Bos Taurus)
Mammalia WISP1 33 34
  • 83.47 (n)
mouse
(Mus musculus)
Mammalia Wisp1 33 16 34
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Wisp1 33
  • 83.38 (n)
oppossum
(Monodelphis domestica)
Mammalia WISP1 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WISP1 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves WISP1 33 34
  • 69.45 (n)
lizard
(Anolis carolinensis)
Reptilia WISP1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wisp1 33
  • 66.2 (n)
zebrafish
(Danio rerio)
Actinopterygii wisp1b 33 34
  • 59.46 (n)
wisp1a 34
  • 57 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for WISP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP1 Gene

ENSEMBL:
Gene Tree for WISP1 (if available)
TreeFam:
Gene Tree for WISP1 (if available)

Paralogs for WISP1 Gene

Paralogs for WISP1 Gene

(7) SIMAP similar genes for WISP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WISP1: view

Variants for WISP1 Gene

Sequence variations from dbSNP and Humsavar for WISP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000043982 -- 133,212,155(+) G/A intron_variant
rs1000066079 -- 133,201,247(+) G/A intron_variant
rs1000182209 -- 133,201,623(+) C/T intron_variant
rs1000198946 -- 133,209,497(+) T/C intron_variant
rs1000208188 -- 133,214,948(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WISP1 Gene

Variant ID Type Subtype PubMed ID
esv1498080 CNV insertion 17803354
esv1593495 CNV insertion 17803354
nsv1132172 CNV deletion 24896259
nsv512967 CNV insertion 21212237
nsv958517 CNV insertion 24416366

Variation tolerance for WISP1 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WISP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WISP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WISP1 Gene

Disorders for WISP1 Gene

Additional Disease Information for WISP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WISP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WISP1 Gene

Publications for WISP1 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D … Levine AJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. (PMID: 17593496) Urano T … Inoue S (Journal of bone and mineral metabolism 2007) 3 22 44 58
  3. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. (PMID: 11782444) Su F … Levine AJ (Genes & development 2002) 3 4 22 58
  4. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (PMID: 11571650) Tanaka S … Sugimachi K (Oncogene 2001) 3 4 22 58
  5. WISP-1 binds to decorin and biglycan. (PMID: 11598131) Desnoyers L … Pennica D (The Journal of biological chemistry 2001) 3 4 22 58

Products for WISP1 Gene

Sources for WISP1 Gene

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