WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interac... See more...

Aliases for WIPI2 Gene

Aliases for WIPI2 Gene

  • WD Repeat Domain, Phosphoinositide Interacting 2 2 3 5
  • WD Repeat Domain Phosphoinositide-Interacting Protein 2 3 4
  • WIPI49-Like Protein 2 3 4
  • WIPI-2 3 4
  • WD40 Repeat Protein Interacting With Phosphoinositides 2 3
  • ATG18B 3
  • CGI-50 3
  • IDDSSA 3
  • Atg21 3

External Ids for WIPI2 Gene

Previous GeneCards Identifiers for WIPI2 Gene

  • GC07P005006
  • GC07P005196
  • GC07P005229
  • GC07P005144

Summaries for WIPI2 Gene

Entrez Gene Summary for WIPI2 Gene

  • WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WIPI2 Gene

WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2) is a Protein Coding gene. Diseases associated with WIPI2 include Intellectual Developmental Disorder With Short Stature And Variable Skeletal Anomalies and Neurodegeneration With Brain Iron Accumulation 5. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is WIPI1.

UniProtKB/Swiss-Prot Summary for WIPI2 Gene

  • Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066).
  • [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.

Gene Wiki entry for WIPI2 Gene

Additional gene information for WIPI2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WIPI2 Gene

Genomics for WIPI2 Gene

GeneHancer (GH) Regulatory Elements for WIPI2 Gene

Promoters and enhancers for WIPI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J005189 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 514.9 +0.6 624 2.8 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 POLR2G SP1 PHF8 PHB2 ZFX WIPI2 RF00017-6009 RF00017-6003 RF00017-6005
GH07J005214 Promoter 0.3 EPDnew 500.4 +23.9 23889 0.1 WIPI2 RF00017-6009 RF00017-6003 RF00017-6005
GH07J005229 Enhancer 0.9 ENCODE 38.3 +41.2 41193 3.8 SIN3A USF1 SP1 NCOR1 EP300 ZIC2 RELA MEF2C RCOR1 TRIM22 NONHSAG046844.2 WIPI2 RF00017-6010 RF00017-6003 RF00017-6005
GH07J004973 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -215.5 -215495 2.6 ZNF217 CTCF NRF1 POLR2G SP1 PHF8 ZFX ZNF639 ZBTB5 ZIC2 RNF216P1 RBAK lnc-RBAK-RBAKDN-2 RNF216 FOXK1 WIPI2 TNRC18 hsa-miR-5096-080 RF00017-5996 RF00017-5995
GH07J004681 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -506.6 -506624 4.4 CTCF SIN3A USF1 SP1 BCLAF1 PHF8 JUND PHB2 FOS ZFX TNRC18 RBAK RNF216P1 AP5Z1 ENSG00000188365 FOXK1 FSCN1 WIPI2 SNORD13P2 piR-32287-096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WIPI2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WIPI2

Top Transcription factor binding sites by QIAGEN in the WIPI2 gene promoter:
  • FAC1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Nkx2-5
  • p53
  • Sp1

Genomic Locations for WIPI2 Gene

Genomic Locations for WIPI2 Gene
chr7:5,190,196-5,233,855
(GRCh38/hg38)
Size:
43,660 bases
Orientation:
Plus strand
chr7:5,229,819-5,273,486
(GRCh37/hg19)
Size:
43,668 bases
Orientation:
Plus strand

Genomic View for WIPI2 Gene

Genes around WIPI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPI2 Gene

Proteins for WIPI2 Gene

  • Protein details for WIPI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4P8-WIPI2_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 2
    Protein Accession:
    Q9Y4P8
    Secondary Accessions:
    • B3KNC2
    • Q5MNZ8
    • Q6FI96
    • Q75L50
    • Q96IE4
    • Q9Y364

    Protein attributes for WIPI2 Gene

    Size:
    454 amino acids
    Molecular mass:
    49408 Da
    Quaternary structure:
    • Interacts with TECPR1 (PubMed:21575909). Interacts with ATG16L1 (PubMed:24954904, PubMed:28561066). Interacts with ATG5 (PubMed:24954904). Interacts with WIPI1 (PubMed:28561066). Interacts with WDR45 (PubMed:28561066). May interact with NUDC (PubMed:28561066).

    Alternative splice isoforms for WIPI2 Gene

neXtProt entry for WIPI2 Gene

Post-translational modifications for WIPI2 Gene

  • Ubiquitination at Lys223, Lys331, and Lys341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WIPI2 Gene

Domains & Families for WIPI2 Gene

Gene Families for WIPI2 Gene

Protein Domains for WIPI2 Gene

Suggested Antigen Peptide Sequences for WIPI2 Gene

GenScript: Design optimal peptide antigens:
  • WIPI49-like protein 2 (WIPI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4P8

UniProtKB/Swiss-Prot:

WIPI2_HUMAN :
  • The FRRG motif is required for recruitment to PtdIns3P.
  • Belongs to the WD repeat SVP1 family.
Domain:
  • The FRRG motif is required for recruitment to PtdIns3P.
Family:
  • Belongs to the WD repeat SVP1 family.
genes like me logo Genes that share domains with WIPI2: view

Function for WIPI2 Gene

Molecular function for WIPI2 Gene

UniProtKB/Swiss-Prot Function:
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066).
UniProtKB/Swiss-Prot Function:
[Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
UniProtKB/Swiss-Prot Induction:
Expression is repressed by ZKSCAN3.

Phenotypes From GWAS Catalog for WIPI2 Gene

Gene Ontology (GO) - Molecular Function for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21044950
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IDA,IBA 20505359
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IBA,IDA 20505359
genes like me logo Genes that share ontologies with WIPI2: view
genes like me logo Genes that share phenotypes with WIPI2: view

Human Phenotype Ontology for WIPI2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPI2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPI2 Gene

Localization for WIPI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPI2 Gene

Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269 PubMed:24954904}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIPI2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IDA 22456507
GO:0005654 nucleoplasm IDA --
GO:0005776 NOT colocalizes_with autophagosome IDA,IEA 20505359
GO:0005829 cytosol TAS --
GO:0016020 colocalizes_with membrane IDA 25578879
genes like me logo Genes that share ontologies with WIPI2: view

Pathways & Interactions for WIPI2 Gene

genes like me logo Genes that share pathways with WIPI2: view

Pathways by source for WIPI2 Gene

2 Reactome pathways for WIPI2 Gene
3 KEGG pathways for WIPI2 Gene
1 R&D Systems pathway for WIPI2 Gene

SIGNOR curated interactions for WIPI2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 20505359
GO:0000422 autophagy of mitochondrion IBA 21873635
GO:0006497 protein lipidation IBA 21873635
GO:0006914 autophagy IEA --
GO:0009267 cellular response to starvation IDA 28561066
genes like me logo Genes that share ontologies with WIPI2: view

Drugs & Compounds for WIPI2 Gene

No Compound Related Data Available

Transcripts for WIPI2 Gene

mRNA/cDNA for WIPI2 Gene

6 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPI2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPI2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:

Relevant External Links for WIPI2 Gene

GeneLoc Exon Structure for
WIPI2

Expression for WIPI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WIPI2 Gene

Protein differential expression in normal tissues from HIPED for WIPI2 Gene

This gene is overexpressed in Testis (15.2) and Fetal Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WIPI2 Gene



Protein tissue co-expression partners for WIPI2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WIPI2

SOURCE GeneReport for Unigene cluster for WIPI2 Gene:

Hs.122363

mRNA Expression by UniProt/SwissProt for WIPI2 Gene:

Q9Y4P8-WIPI2_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.

Evidence on tissue expression from TISSUES for WIPI2 Gene

  • Skin(4.5)
  • Nervous system(4.3)
  • Lung(3)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with WIPI2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIPI2 Gene

Orthologs for WIPI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WIPI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPI2 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WIPI2 31 30
  • 88.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wipi2 17 31 30
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Wipi2 30
  • 87.16 (n)
cow
(Bos Taurus)
Mammalia WIPI2 31 30
  • 87.08 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPI2 31
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WIPI2 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPI2 31 30
  • 81.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPI2 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497399 30
  • 74.9 (n)
Str.10600 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53220 30
zebrafish
(Danio rerio)
Actinopterygii wipi2 31
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14106 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005910 30
  • 64.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg18 31 30
  • 62.17 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-18 31 30
  • 51.42 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL119W 30
  • 48.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG18 33 31 30
  • 48.12 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04664g 30
  • 47.36 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons G18B 30
  • 44.4 (n)
rice
(Oryza sativa)
Liliopsida Os02g0791800 30
  • 44.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 69 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
Cin.1716 30
bread mold
(Neurospora crassa)
Ascomycetes NCU03441 30
  • 52.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg18 30
  • 45.66 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1716 30
Species where no ortholog for WIPI2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIPI2 Gene

ENSEMBL:
Gene Tree for WIPI2 (if available)
TreeFam:
Gene Tree for WIPI2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WIPI2: view image

Paralogs for WIPI2 Gene

Paralogs for WIPI2 Gene

(1) SIMAP similar genes for WIPI2 Gene using alignment to 2 proteins:

  • WIPI2_HUMAN
  • L8E8Q1_HUMAN

Pseudogenes.org Pseudogenes for WIPI2 Gene

genes like me logo Genes that share paralogs with WIPI2: view

Variants for WIPI2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WIPI2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
710689 Benign: not provided 5,216,554(+) C/T INTRON_VARIANT
716002 Likely Benign: not provided 5,216,578(+) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
727096 Benign: not provided 5,228,143(+) C/T SYNONYMOUS_VARIANT
737614 Likely Benign: not provided 5,228,095(+) T/G INTRON_VARIANT
745846 Likely Benign: not provided 5,230,866(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WIPI2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WIPI2 Gene

Variant ID Type Subtype PubMed ID
dgv3482n106 OTHER inversion 24896259
esv2498578 CNV deletion 19546169
nsv1015639 CNV loss 25217958
nsv1144164 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv5627 CNV insertion 18451855
nsv8034 CNV gain 18304495
nsv823995 CNV gain 20364138
nsv830889 CNV loss 17160897

Variation tolerance for WIPI2 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIPI2 Gene

Human Gene Mutation Database (HGMD)
WIPI2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIPI2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPI2 Gene

Disorders for WIPI2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WIPI2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, DISEASES, and GeneCards

UniProtKB/Swiss-Prot

WIPI2_HUMAN
  • Intellectual developmental disorder with short stature and variable skeletal anomalies (IDDSSA) [MIM:618453]: An autosomal recessive disorder characterized by severe mental retardation, speech and language impairment, developmental delay, and cardiac, thyroid and skeletal abnormalities. Skeletal features include short stature, camptodactyly, fifth finger clinodactyly, thumb hypoplasia, overlapping toes, and kyphosis or lumbar vertebral abnormalities. {ECO:0000269 PubMed:30968111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WIPI2

genes like me logo Genes that share disorders with WIPI2: view

No data available for Genatlas for WIPI2 Gene

Publications for WIPI2 Gene

  1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T … Nordheim A (Oncogene 2004) 2 3 4 54
  2. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. (PMID: 28561066) Bakula D … Proikas-Cezanne T (Nature communications 2017) 3 4 54
  3. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. (PMID: 24954904) Dooley HC … Tooze SA (Molecular cell 2014) 3 4 54
  4. Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. (PMID: 22456507) Orsi A … Tooze SA (Molecular biology of the cell 2012) 3 4 54
  5. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (PMID: 21575909) Ogawa M … Sasakawa C (Cell host & microbe 2011) 3 4 54

Products for WIPI2 Gene

Sources for WIPI2 Gene