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Aliases for WIPF3 Gene

Aliases for WIPF3 Gene

  • WAS/WASL Interacting Protein Family Member 3 2 3 5
  • Corticosteroids And Regional Expression Protein 16 Homolog 3 4
  • CR16 3 4
  • WAS/WASL Interacting Protein Family, Member 3 2
  • WAS/WASL-Interacting Protein Family Member 3 3

External Ids for WIPF3 Gene

Summaries for WIPF3 Gene

GeneCards Summary for WIPF3 Gene

WIPF3 (WAS/WASL Interacting Protein Family Member 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to this gene include actin binding and SH3 domain binding. An important paralog of this gene is WIPF2.

UniProtKB/Swiss-Prot for WIPF3 Gene

  • May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

Additional gene information for WIPF3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF3 Gene

Genomics for WIPF3 Gene

GeneHancer (GH) Regulatory Elements for WIPF3 Gene

Promoters and enhancers for WIPF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I029805 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.4 371 2.5 BCOR CTCF MXI1 RB1 GTF2E2 SIN3A ZMYM3 ZIC2 ZNF335 CCNT2 WIPF3 DPY19L2P3 MTURN GC07P029912
GH07I029826 Promoter 0.7 EPDnew 550.4 +19.8 19839 0.1 ZNF184 PRDM10 WIPF3 ENSG00000238906 GC07P029912
GH07I029838 Enhancer 0.9 ENCODE dbSUPER 12.1 +33.6 33582 2.8 CTCF ZNF146 ATF1 JUN CHAMP1 NFYB SCRT2 SMC3 TRIM24 ATF7 WIPF3 GC07P029912
GH07I029793 Enhancer 0.9 ENCODE 7.9 -12.8 -12844 1 ATF1 PKNOX1 ARNT SIN3A NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 ENSG00000238906 WIPF3 DPY19L2P3 LOC101928208
GH07I029795 Enhancer 0.7 ENCODE 7.9 -10.6 -10586 0.2 HDAC1 MEIS2 PKNOX1 TEAD4 TAL1 TCF12 CTBP1 NCOR1 CBFA2T2 TRIM24 WIPF3 LOC101928208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WIPF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WIPF3 gene promoter:

Genomic Locations for WIPF3 Gene

Genomic Locations for WIPF3 Gene
110,581 bases
Plus strand

Genomic View for WIPF3 Gene

Genes around WIPF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF3 Gene

Proteins for WIPF3 Gene

  • Protein details for WIPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAS/WASL-interacting protein family member 3
    Protein Accession:
    Secondary Accessions:
    • B8ZZV2

    Protein attributes for WIPF3 Gene

    483 amino acids
    Molecular mass:
    49458 Da
    Quaternary structure:
    • Interacts with WASL, and monomeric and filamentous actin.

neXtProt entry for WIPF3 Gene

Post-translational modifications for WIPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPF3 Gene

No data available for DME Specific Peptides for WIPF3 Gene

Domains & Families for WIPF3 Gene

Gene Families for WIPF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WIPF3 Gene


Suggested Antigen Peptide Sequences for WIPF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WH2 domain is found in a number of putative actin-binding proteins.
  • Belongs to the verprolin family.
  • The WH2 domain is found in a number of putative actin-binding proteins.
  • The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains.
  • The KLKR motif is essential for G-actin binding and for actin polymerization.
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF3: view

Function for WIPF3 Gene

Molecular function for WIPF3 Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

Phenotypes From GWAS Catalog for WIPF3 Gene

Gene Ontology (GO) - Molecular Function for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with WIPF3: view

Phenotypes for WIPF3 Gene

genes like me logo Genes that share phenotypes with WIPF3: view

Animal Models for WIPF3 Gene

MGI Knock Outs for WIPF3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WIPF3 Gene

Localization for WIPF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF3 Gene

Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIPF3 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WIPF3: view

Pathways & Interactions for WIPF3 Gene

genes like me logo Genes that share pathways with WIPF3: view

Gene Ontology (GO) - Biological Process for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with WIPF3: view

No data available for SIGNOR curated interactions for WIPF3 Gene

Drugs & Compounds for WIPF3 Gene

No Compound Related Data Available

Transcripts for WIPF3 Gene

mRNA/cDNA for WIPF3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WIPF3 Gene

WAS/WASL interacting protein family, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF3 Gene

No ASD Table

Relevant External Links for WIPF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WIPF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WIPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIPF3 Gene

This gene is overexpressed in Ovary (x6.2), Brain - Hippocampus (x4.6), Brain - Putamen (basal ganglia) (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for WIPF3 Gene

This gene is overexpressed in Testis (34.2), Frontal cortex (10.8), Ovary (10.3), and Fetal ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WIPF3 Gene

Protein tissue co-expression partners for WIPF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WIPF3 Gene:


SOURCE GeneReport for Unigene cluster for WIPF3 Gene:

genes like me logo Genes that share expression patterns with WIPF3: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIPF3 Gene

Orthologs for WIPF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WIPF3 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia WIPF3 33 34
  • 85.6 (n)
(Bos Taurus)
Mammalia WIPF3 33 34
  • 82.41 (n)
(Mus musculus)
Mammalia Wipf3 33 16 34
  • 81.24 (n)
(Rattus norvegicus)
Mammalia Wipf3 33
  • 78.86 (n)
(Monodelphis domestica)
Mammalia WIPF3 34
  • 52 (a)
(Gallus gallus)
Aves WIPF3 34
  • 48 (a)
(Anolis carolinensis)
Reptilia WIPF3 34
  • 42 (a)
(Danio rerio)
Actinopterygii WIPF3 34
  • 33 (a)
Species where no ortholog for WIPF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF3 Gene

Gene Tree for WIPF3 (if available)
Gene Tree for WIPF3 (if available)

Paralogs for WIPF3 Gene

Paralogs for WIPF3 Gene

genes like me logo Genes that share paralogs with WIPF3: view

Variants for WIPF3 Gene

Sequence variations from dbSNP and Humsavar for WIPF3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000006871 -- 29,914,508(+) C/T coding_sequence_variant, missense_variant
rs1000017636 -- 29,841,676(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000017766 -- 29,812,938(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000046178 -- 29,892,970(+) C/T intron_variant
rs1000077373 -- 29,893,305(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WIPF3 Gene

Variant ID Type Subtype PubMed ID
esv1527161 CNV deletion 17803354
esv2676972 CNV deletion 23128226
esv2734190 CNV deletion 23290073
esv2734191 CNV deletion 23290073
esv2734192 CNV deletion 23290073
esv2734193 CNV deletion 23290073
esv2759521 CNV gain 17122850
esv2762662 CNV loss 21179565
esv3612704 CNV loss 21293372
nsv1019527 CNV gain 25217958
nsv1068321 OTHER inversion 25765185
nsv1075021 CNV deletion 25765185
nsv1148830 OTHER inversion 26484159
nsv478424 CNV novel sequence insertion 20440878
nsv5682 CNV insertion 18451855
nsv830936 CNV gain 17160897

Variation tolerance for WIPF3 Gene

Gene Damage Index Score: 3.55; 55.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIPF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF3 Gene

Disorders for WIPF3 Gene

Additional Disease Information for WIPF3

No disorders were found for WIPF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPF3 Gene

Publications for WIPF3 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  2. The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. (PMID: 12372256) Zettl M … Way M (Current biology : CB 2002) 3 4 58
  3. Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin. (PMID: 28161632) Kropyvko S … Rynditch A (Biochemical and biophysical research communications 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for WIPF3 Gene

Sources for WIPF3 Gene

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