This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008] See more...

Aliases for WIPF2 Gene

Aliases for WIPF2 Gene

  • WAS/WASL Interacting Protein Family Member 2 2 3 5
  • WAS/WASL-Interacting Protein Family Member 2 3 4
  • WASP-Interacting Protein-Related Protein 3 4
  • WIP- And CR16-Homologous Protein 3 4
  • WIP-Related Protein 3 4
  • WICH 3 4
  • WIRE 3 4
  • WAS/WASL Interacting Protein Family, Member 2 2
  • WASP-Binding Protein 3

External Ids for WIPF2 Gene

Previous GeneCards Identifiers for WIPF2 Gene

  • GC17P035630
  • GC17P038375
  • GC17P034168

Summaries for WIPF2 Gene

Entrez Gene Summary for WIPF2 Gene

  • This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]

GeneCards Summary for WIPF2 Gene

WIPF2 (WAS/WASL Interacting Protein Family Member 2) is a Protein Coding gene. Diseases associated with WIPF2 include Hemopericardium and Actinomycosis. Among its related pathways are Yersinia infection and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.

UniProtKB/Swiss-Prot Summary for WIPF2 Gene

  • Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Wiki entry for WIPF2 Gene

Additional gene information for WIPF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WIPF2 Gene

Genomics for WIPF2 Gene

GeneHancer (GH) Regulatory Elements for WIPF2 Gene

Promoters and enhancers for WIPF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WIPF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WIPF2

Top Transcription factor binding sites by QIAGEN in the WIPF2 gene promoter:
  • AhR
  • Arnt
  • MZF-1
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox5

Genomic Locations for WIPF2 Gene

Genomic Locations for WIPF2 Gene
chr17:40,219,304-40,284,136
(GRCh38/hg38)
Size:
64,833 bases
Orientation:
Plus strand
chr17:38,375,556-38,440,388
(GRCh37/hg19)
Size:
64,833 bases
Orientation:
Plus strand

Genomic View for WIPF2 Gene

Genes around WIPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF2 Gene

Proteins for WIPF2 Gene

  • Protein details for WIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF74-WIPF2_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 2
    Protein Accession:
    Q8TF74
    Secondary Accessions:
    • A8K0L3
    • Q658J8
    • Q71RE1
    • Q8TE44

    Protein attributes for WIPF2 Gene

    Size:
    440 amino acids
    Molecular mass:
    46289 Da
    Quaternary structure:
    • Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.
    Miscellaneous:
    • Access to the profilin-binding site is masked in the full-length protein.
    SequenceCaution:
    • Sequence=AAQ15232.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for WIPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPF2 Gene

Post-translational modifications for WIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WIPF2 Gene

Domains & Families for WIPF2 Gene

Gene Families for WIPF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WIPF2 Gene

Blocks:
  • Actin-binding WH2
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ30495 fis, clone BRAWH2000323, moderately similar to WIP-related protein (A8MWR2_HUMAN)
  • WIP-related protein (WIPF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF74

UniProtKB/Swiss-Prot:

WIPF2_HUMAN :
  • Belongs to the verprolin family.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF2: view

Function for WIPF2 Gene

Molecular function for WIPF2 Gene

UniProtKB/Swiss-Prot Function:
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Phenotypes From GWAS Catalog for WIPF2 Gene

Gene Ontology (GO) - Molecular Function for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20936779
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with WIPF2: view
genes like me logo Genes that share phenotypes with WIPF2: view

Animal Model Products

CRISPR Products

miRNA for WIPF2 Gene

miRTarBase miRNAs that target WIPF2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPF2 Gene

Localization for WIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF2 Gene

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIPF2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IBA 21873635
genes like me logo Genes that share ontologies with WIPF2: view

Pathways & Interactions for WIPF2 Gene

genes like me logo Genes that share pathways with WIPF2: view

Pathways by source for WIPF2 Gene

2 GeneGo (Thomson Reuters) pathways for WIPF2 Gene
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B

Gene Ontology (GO) - Biological Process for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000147 actin cortical patch assembly IBA 21873635
GO:0006897 endocytosis IBA 21873635
GO:0030048 actin filament-based movement IBA 21873635
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0051666 actin cortical patch localization IBA 21873635
genes like me logo Genes that share ontologies with WIPF2: view

No data available for SIGNOR curated interactions for WIPF2 Gene

Drugs & Compounds for WIPF2 Gene

No Compound Related Data Available

Transcripts for WIPF2 Gene

mRNA/cDNA for WIPF2 Gene

1 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPF2

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: -
SP6: - - - - - - -
SP7: - -

Relevant External Links for WIPF2 Gene

GeneLoc Exon Structure for
WIPF2

Expression for WIPF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WIPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WIPF2 Gene

This gene is overexpressed in Pancreas (14.5), Heart (13.8), Frontal cortex (13.3), and Pancreatic juice (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WIPF2 Gene



Protein tissue co-expression partners for WIPF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WIPF2

SOURCE GeneReport for Unigene cluster for WIPF2 Gene:

Hs.421622

mRNA Expression by UniProt/SwissProt for WIPF2 Gene:

Q8TF74-WIPF2_HUMAN
Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.

Evidence on tissue expression from TISSUES for WIPF2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with WIPF2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIPF2 Gene

Orthologs for WIPF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPF2 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF2 31 30
  • 93.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WIPF2 31 30
  • 91.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wipf2 17 31 30
  • 89.4 (n)
rat
(Rattus norvegicus)
Mammalia Wipf2 30
  • 88.01 (n)
oppossum
(Monodelphis domestica)
Mammalia WIPF2 31
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPF2 31
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPF2 31 30
  • 74.76 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPF2 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wipf2 30
  • 66.5 (n)
Str.4454 30
African clawed frog
(Xenopus laevis)
Amphibia MGC69127 30
zebrafish
(Danio rerio)
Actinopterygii wipf2b 31 30
  • 63.11 (n)
OneToMany
WIPF2 (2 of 2) 31
  • 52 (a)
OneToMany
Dr.12755 30
Species where no ortholog for WIPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF2 Gene

ENSEMBL:
Gene Tree for WIPF2 (if available)
TreeFam:
Gene Tree for WIPF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WIPF2: view image

Paralogs for WIPF2 Gene

Paralogs for WIPF2 Gene

(1) SIMAP similar genes for WIPF2 Gene using alignment to 5 proteins:

  • WIPF2_HUMAN
  • A8MWR2_HUMAN
  • J3KSA3_HUMAN
  • J3QKM5_HUMAN
  • J3QQS0_HUMAN
genes like me logo Genes that share paralogs with WIPF2: view

Variants for WIPF2 Gene

Additional dbSNP identifiers (rs#s) for WIPF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WIPF2 Gene

Variant ID Type Subtype PubMed ID
dgv179n21 CNV loss 19592680
esv2372222 CNV deletion 18987734
esv2430508 CNV deletion 19546169
esv2668303 CNV deletion 23128226
esv2676976 CNV deletion 23128226
esv2715907 CNV deletion 23290073
esv3156012 CNV deletion 24192839
esv3554412 CNV deletion 23714750
esv3640553 CNV loss 21293372
nsv1071066 CNV deletion 25765185
nsv1112294 CNV deletion 24896259
nsv1121524 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv525796 CNV gain 19592680
nsv833444 CNV loss 17160897
nsv955414 CNV deletion 24416366

Variation tolerance for WIPF2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIPF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WIPF2 Gene

Disorders for WIPF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WIPF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemopericardium
  • haemopericardium
actinomycosis
  • actinomycetoma
- elite association - COSMIC cancer census association via MalaCards
Search WIPF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WIPF2

genes like me logo Genes that share disorders with WIPF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIPF2 Gene

Publications for WIPF2 Gene

  1. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PMID: 12213210) Aspenström P (Experimental cell research 2002) 2 3 4 23 54
  2. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PMID: 11829459) Kato M … Takenawa T (Biochemical and biophysical research communications 2002) 2 3 4 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54

Products for WIPF2 Gene

Sources for WIPF2 Gene