Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008] See more...
Aliases for WIPF2 Gene
Aliases for WIPF2 Gene
External Ids for WIPF2 Gene
- HGNC: 30923
- Entrez Gene: 147179
- Ensembl: ENSG00000171475
- OMIM: 609692
- UniProtKB: Q8TF74
Previous GeneCards Identifiers for WIPF2 Gene
- GC17P035630
- GC17P038375
- GC17P034168
Summaries for WIPF2 Gene
-
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
GeneCards Summary for WIPF2 Gene
WIPF2 (WAS/WASL Interacting Protein Family Member 2) is a Protein Coding gene. Diseases associated with WIPF2 include Hemopericardium and Dermoid Cyst Of Ovary. Among its related pathways are Signaling by GPCR and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.
UniProtKB/Swiss-Prot Summary for WIPF2 Gene
-
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
Additional gene information for WIPF2 Gene
- HGNC(30923)
- Entrez Gene(147179)
- Ensembl(ENSG00000171475)
- OMIM(609692)
- UniProtKB(Q8TF74)
- Open Targets Platform(ENSG00000171475)
- Search for WIPF2 at DataMed
- Search for WIPF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WIPF2 Gene
Genomics for WIPF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WIPF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WIPF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WIPF2
- Top Transcription factor binding sites by QIAGEN in the WIPF2 gene promoter:
-
- AhR
- Arnt
- MZF-1
- NF-1
- NF-kappaB
- NF-kappaB1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- Sox5
Genomic Locations for WIPF2 Gene
Genomic Locations for WIPF2 Gene
- chr17:40,219,304-40,284,136
- (GRCh38/hg38)
- Size:
- 64,833 bases
- Orientation:
- Plus strand
- chr17:38,375,556-38,440,388
- (GRCh37/hg19)
- Size:
- 64,833 bases
- Orientation:
- Plus strand
Genomic View for WIPF2 Gene
Genes around WIPF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by HGNC
- 17q21.2 by Entrez Gene
- 17q21.2 by Ensembl
WIPF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WIPF2 Gene
Proteins for WIPF2 Gene
-
Protein details for WIPF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TF74-WIPF2_HUMAN
- Recommended name:
- WAS/WASL-interacting protein family member 2
- Protein Accession:
- Q8TF74
- A8K0L3
- Q658J8
- Q71RE1
- Q8TE44
Protein attributes for WIPF2 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 46289 Da
- Quaternary structure:
-
- Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.
- SequenceCaution:
-
- Sequence=AAQ15232.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Access to the profilin-binding site is masked in the full-length protein.
Protein Expression for WIPF2 Gene
Post-translational modifications for WIPF2 Gene
Other Protein References for WIPF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for WIPF2
- Novus Biologicals Antibodies for WIPF2
-
Abcam antibodies for WIPF2
- Invitrogen Antibodies for WIPF2 (AFLGC-Wipf2)
Protein Products
-
OriGene Purified Proteins for WIPF2
- Search Origene for MassSpec and Protein Over-expression Lysates for WIPF2
- Origene Custom Protein Services for WIPF2
No data available for DME Specific Peptides for WIPF2 Gene
Domains & Families for WIPF2 Gene
Gene Families for WIPF2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for WIPF2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ30495 fis, clone BRAWH2000323, moderately similar to WIP-related protein (A8MWR2_HUMAN)
- WIP-related protein (WIPF2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TF74- Family:
-
- Belongs to the verprolin family.
Function for WIPF2 Gene
Molecular function for WIPF2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
Phenotypes From GWAS Catalog for WIPF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 20936779 |
| GO:0051015 | actin filament binding | IBA | -- |
Phenotypes for WIPF2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WIPF2 - Select products 50% OFF >
- * WIPF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WIPF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WIPF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for WIPF2
miRNA for WIPF2 Gene
- miRTarBase miRNAs that target WIPF2
-
- mmu-miR-7b-5p (MIRT009412)
- hsa-miR-92a-3p (MIRT049127)
- hsa-miR-1245a (MIRT077025)
- hsa-miR-8079 (MIRT077031)
- hsa-miR-3591-5p (MIRT196985)
- hsa-miR-7854-3p (MIRT344872)
- hsa-miR-5197-3p (MIRT344878)
- mmu-miR-7a-1-3p (MIRT438865)
- mmu-miR-7a-2-3p (MIRT438866)
- hsa-miR-218-5p (MIRT439285)
- hsa-miR-4276 (MIRT463948)
- hsa-miR-6077 (MIRT463949)
- hsa-miR-5190 (MIRT463950)
- hsa-miR-3919 (MIRT463951)
- hsa-miR-4688 (MIRT463952)
- hsa-miR-6743-5p (MIRT463953)
- hsa-miR-6859-5p (MIRT463954)
- hsa-miR-3916 (MIRT463955)
- hsa-miR-3125 (MIRT463956)
- hsa-miR-3184-5p (MIRT463957)
- hsa-miR-423-5p (MIRT463958)
- hsa-miR-4766-5p (MIRT463959)
- hsa-miR-6858-5p (MIRT463960)
- hsa-miR-4689 (MIRT463961)
- hsa-miR-4473 (MIRT463962)
- hsa-miR-4671-3p (MIRT463963)
- hsa-miR-4710 (MIRT463964)
- hsa-miR-520f-3p (MIRT463965)
- hsa-miR-302c-3p (MIRT463966)
- hsa-miR-512-3p (MIRT463967)
- hsa-miR-2278 (MIRT463968)
- hsa-miR-1276 (MIRT463969)
- hsa-miR-361-5p (MIRT533163)
- hsa-miR-3619-3p (MIRT533164)
- hsa-miR-2115-3p (MIRT533165)
- hsa-miR-3163 (MIRT533166)
- hsa-miR-6816-3p (MIRT533167)
- hsa-miR-8080 (MIRT533168)
- hsa-miR-449c-3p (MIRT552845)
- hsa-miR-8086 (MIRT552846)
- hsa-miR-3121-5p (MIRT552847)
- hsa-miR-454-3p (MIRT552848)
- hsa-miR-3666 (MIRT552849)
- hsa-miR-4295 (MIRT552850)
- hsa-miR-301b-3p (MIRT552851)
- hsa-miR-301a-3p (MIRT552852)
- hsa-miR-130b-3p (MIRT552853)
- hsa-miR-130a-3p (MIRT552854)
- hsa-miR-8062 (MIRT552855)
- hsa-miR-519c-3p (MIRT552856)
- hsa-miR-519b-3p (MIRT552857)
- hsa-miR-519a-3p (MIRT552858)
- hsa-miR-6796-3p (MIRT552859)
- hsa-miR-99b-3p (MIRT552860)
- hsa-miR-99a-3p (MIRT552861)
- hsa-miR-7109-3p (MIRT552862)
- hsa-miR-106b-5p (MIRT552863)
- hsa-miR-106a-5p (MIRT552864)
- hsa-miR-93-5p (MIRT552865)
- hsa-miR-526b-3p (MIRT552866)
- hsa-miR-20b-5p (MIRT552867)
- hsa-miR-17-5p (MIRT552868)
- hsa-miR-20a-5p (MIRT552869)
- hsa-miR-519d-3p (MIRT552870)
- mmu-miR-5135 (MIRT588476)
- mmu-miR-470-5p (MIRT596386)
- mmu-miR-1965 (MIRT600177)
- mmu-miR-1946b (MIRT600178)
- mmu-miR-1946a (MIRT600179)
- mmu-miR-34c-5p (MIRT600180)
- mmu-miR-449a-5p (MIRT600181)
- mmu-miR-34a-5p (MIRT600182)
- mmu-miR-449b (MIRT600183)
- mmu-miR-34b-5p (MIRT600184)
- mmu-miR-449c-5p (MIRT600185)
- mmu-miR-323-5p (MIRT600186)
- mmu-miR-3102-5p (MIRT600187)
- mmu-miR-669e-5p (MIRT605915)
- mmu-miR-431-5p (MIRT605916)
- mmu-miR-694 (MIRT605917)
- mmu-miR-1192 (MIRT605918)
- mmu-miR-495-3p (MIRT605919)
- mmu-miR-10a-5p (MIRT606589)
- mmu-miR-10b-5p (MIRT606590)
- mmu-miR-339-5p (MIRT606591)
- hsa-miR-129-5p (MIRT611247)
- hsa-miR-450a-5p (MIRT611248)
- hsa-miR-6821-5p (MIRT611249)
- hsa-miR-1273g-5p (MIRT611250)
- hsa-miR-203a-5p (MIRT611251)
- hsa-miR-599 (MIRT627295)
- hsa-miR-3161 (MIRT627296)
- hsa-miR-4668-5p (MIRT627297)
- hsa-miR-766-5p (MIRT627298)
- hsa-miR-580-3p (MIRT638119)
- hsa-miR-7977 (MIRT638120)
- hsa-miR-7160-5p (MIRT638121)
- hsa-miR-6134 (MIRT638122)
- hsa-miR-6770-5p (MIRT638123)
- hsa-miR-1253 (MIRT638124)
- hsa-miR-7162-3p (MIRT638125)
- hsa-miR-383-3p (MIRT638126)
- hsa-miR-372-5p (MIRT714238)
- hsa-miR-371a-5p (MIRT714239)
- hsa-miR-616-5p (MIRT714240)
- hsa-miR-373-5p (MIRT714241)
- hsa-miR-371b-5p (MIRT714242)
- hsa-miR-5699-3p (MIRT714243)
- hsa-miR-4421 (MIRT714244)
- hsa-miR-6748-3p (MIRT714245)
- hsa-miR-4793-5p (MIRT714246)
- hsa-miR-3613-3p (MIRT714247)
- hsa-miR-5692a (MIRT714248)
- hsa-miR-5047 (MIRT723468)
- hsa-miR-1301-3p (MIRT723470)
- hsa-miR-7156-3p (MIRT723471)
- hsa-miR-5581-3p (MIRT723472)
- hsa-miR-4448 (MIRT723473)
- hsa-miR-4758-3p (MIRT723474)
- hsa-miR-3667-3p (MIRT723475)
- hsa-miR-6734-3p (MIRT723476)
- hsa-miR-4267 (MIRT723477)
- hsa-miR-6736-3p (MIRT723478)
- hsa-miR-4323 (MIRT723479)
- hsa-miR-6858-3p (MIRT723480)
- hsa-miR-143-5p (MIRT762707)
- hsa-miR-1976 (MIRT763611)
- hsa-miR-3653-5p (MIRT766405)
- hsa-miR-3690 (MIRT767121)
- hsa-miR-378j (MIRT767534)
- hsa-miR-4254 (MIRT768087)
- hsa-miR-4279 (MIRT768358)
- hsa-miR-4320 (MIRT768598)
- hsa-miR-4722-3p (MIRT771524)
- hsa-miR-498 (MIRT772871)
- hsa-miR-6499-3p (MIRT776413)
- hsa-miR-6727-3p (MIRT777926)
- hsa-miR-6747-3p (MIRT778313)
- hsa-miR-6778-3p (MIRT778841)
- hsa-miR-6839-5p (MIRT780099)
- hsa-miR-5693 (MIRT787794)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WIPF2
- Browse OriGene Inhibitory RNA Products For WIPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPF2
Clone Products
- Applied Biological Materials (abm): Clones for WIPF2 - Select products 50% OFF >
- * WIPF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WIPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WIPF2
Cell Line Products
-
Horizon Cell Lines for WIPF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPF2 Gene
Localization for WIPF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WIPF2 Gene
- Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005884 | actin filament | IBA | 21873635 |
Pathways & Interactions for WIPF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Signaling by Rho GTPases | ||
| 4 | Endocytosis | ||
| 5 | Pathogenic Escherichia coli infection | ||
Pathways by source for WIPF2 Gene
8 Reactome pathways for WIPF2 Gene
3 KEGG pathways for WIPF2 Gene
2 GeneGo (Thomson Reuters) pathways for WIPF2 Gene
- Cytoskeleton remodeling Integrin outside-in signaling
- Cytoskeleton remodeling Reverse signaling by ephrin B
Interacting Proteins for WIPF2 Gene
Selected Interacting proteins:
Q8TF74-WIPF2_HUMAN
ENSP00000320924
for WIPF2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for WIPF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000147 | actin cortical patch assembly | IBA | -- |
| GO:0006897 | endocytosis | IBA | -- |
| GO:0008360 | regulation of cell shape | IBA | -- |
| GO:0030048 | actin filament-based movement | IBA | 21873635 |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
No data available for SIGNOR curated interactions for WIPF2 Gene
Transcripts for WIPF2 Gene
mRNA/cDNA for WIPF2 Gene
- 1 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000323571 7492 nts (view in UCSC)
- ENST00000394103 2378 nts (view in UCSC)
- ENST00000494757 2113 nts (view in UCSC)
- ENST00000578304 439 nts (view in UCSC)
- ENST00000578623 554 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WIPF2 - Select products 50% OFF >
- * WIPF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WIPF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WIPF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for WIPF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WIPF2
- Browse OriGene Inhibitory RNA Products For WIPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPF2
Clone Products
- Applied Biological Materials (abm): Clones for WIPF2 - Select products 50% OFF >
- * WIPF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WIPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WIPF2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for WIPF2 Gene
- GeneLoc Exon Structure for
- WIPF2
Expression for WIPF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
This gene is overexpressed in Pancreas (14.5), Heart (13.8), Frontal cortex (13.3), and Pancreatic juice (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WIPF2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WIPF2
SOURCE GeneReport for Unigene cluster for WIPF2 Gene:
Hs.421622mRNA Expression by UniProt/SwissProt for WIPF2 Gene:
Q8TF74-WIPF2_HUMAN
Tissue specificity:
Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
Evidence on tissue expression from TISSUES for WIPF2 Gene
- Nervous system(4.9)
- Intestine(2.3)
- Lung(2.2)
- Skin(2.2)
Primer Products
-
OriGene qPCR primer pairs for WIPF2
-
OriGene qPCR primer pairs and template standards for WIPF2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIPF2 Gene
Orthologs for WIPF2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WIPF2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WIPF2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WIPF2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Wipf2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wipf2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | WIPF2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WIPF2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WIPF2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WIPF2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wipf2 30 |
|
||
| Str.4454 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69127 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wipf2b 30 31 |
|
OneToMany | |
| WIPF2 (2 of 2) 31 |
|
OneToMany | |||
| Dr.12755 30 |
|
- Species where no ortholog for WIPF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for WIPF2 Gene
- ENSEMBL:
- Gene Tree for WIPF2 (if available)
- TreeFam:
- Gene Tree for WIPF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WIPF2: view image
Paralogs for WIPF2 Gene
Variants for WIPF2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv179n21 | CNV | loss | 19592680 |
| esv2372222 | CNV | deletion | 18987734 |
| esv2430508 | CNV | deletion | 19546169 |
| esv2668303 | CNV | deletion | 23128226 |
| esv2676976 | CNV | deletion | 23128226 |
| esv2715907 | CNV | deletion | 23290073 |
| esv3156012 | CNV | deletion | 24192839 |
| esv3554412 | CNV | deletion | 23714750 |
| esv3640553 | CNV | loss | 21293372 |
| nsv1071066 | CNV | deletion | 25765185 |
| nsv1112294 | CNV | deletion | 24896259 |
| nsv1121524 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv525796 | CNV | gain | 19592680 |
| nsv833444 | CNV | loss | 17160897 |
| nsv955414 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.10;
38.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WIPF2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WIPF2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WIPF2 Gene
Disorders for WIPF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemopericardium |
|
|
| dermoid cyst of ovary |
|
|
Search WIPF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WIPF2
No data available for UniProtKB/Swiss-Prot and Genatlas for WIPF2 Gene
Publications for WIPF2 Gene
- The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PMID: 12213210) Aspenström P (Experimental cell research 2002) 2 3 4 23
- WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PMID: 11829459) Kato M … Takenawa T (Biochemical and biophysical research communications 2002) 2 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
ExternalLinks
Products for WIPF2 Gene
- Custom Antibody ServicesOriGene Antibodies for WIPF2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for WIPF2
- Search Origene for MassSpec and Protein Over-expression Lysates for WIPF2
- Origene Custom Protein Services for WIPF2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WIPF2
- Browse OriGene Inhibitory RNA Products For WIPF2
- OriGene qPCR primer pairs for WIPF2
- OriGene qPCR primer pairs and template standards for WIPF2
- OriGene CRISPR knockouts for WIPF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For WIPF2
- Sino Biological Human cDNA Clone for WIPF2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for WIPF2
- Novus Biologicals proteins and lysates for WIPF2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for WIPF2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for WIPF2 (AFLGC-Wipf2)
- VectorBuilder Custom and pre-made DNA vectors for WIPF2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for WIPF2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for WIPF2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for WIPF2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for WIPF2
- antibodies-online: Show 13 available WIPF2 Antibodies ranked by validation data
- Compare Top WIPF2 Antibodies
- antibodies-online: Search results for available WIPF2 related products ranked by validation data
- antibodies-online: Search results for available WIPF2 related products ranked by validation data
- Horizon Cell Lines for WIPF2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WIPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WIPF2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for WIPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WIPF2
Sources for WIPF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB