Aliases for WIPF1 Gene
External Ids for WIPF1 Gene
Previous HGNC Symbols for WIPF1 Gene
Previous GeneCards Identifiers for WIPF1 Gene
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WIPF1 Gene
WIPF1 (WAS/WASL Interacting Protein Family Member 1) is a Protein Coding gene. Diseases associated with WIPF1 include Wiskott-Aldrich Syndrome 2 and Wiskott-Aldrich Syndrome. Among its related pathways are Signaling by GPCR and Yersinia infection. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is WIPF2.
UniProtKB/Swiss-Prot Summary for WIPF1 Gene
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.