The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has b... See more...

Aliases for WIF1 Gene

Aliases for WIF1 Gene

  • WNT Inhibitory Factor 1 2 3 5
  • Wnt Inhibitory Factor 1 3 4
  • WIF-1 3 4

External Ids for WIF1 Gene

Previous GeneCards Identifiers for WIF1 Gene

  • GC12P064885
  • GC12P065390
  • GC12M065161
  • GC12M063730
  • GC12M065444
  • GC12M062496

Summaries for WIF1 Gene

Entrez Gene Summary for WIF1 Gene

  • The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

GeneCards Summary for WIF1 Gene

WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Colorectal Cancer and Adenoid Cystic Carcinoma. Among its related pathways are Signaling by Wnt and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. An important paralog of this gene is DLL3.

UniProtKB/Swiss-Prot Summary for WIF1 Gene

  • Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Gene Wiki entry for WIF1 Gene

Additional gene information for WIF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WIF1 Gene

Genomics for WIF1 Gene

GeneHancer (GH) Regulatory Elements for WIF1 Gene

Promoters and enhancers for WIF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J065121 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 +0.2 165 0.8 CTCF ZBTB26 HDAC2 ZNF341 EZH2 MYC KLF9 ZBTB17 ZNF263 MXI1 WIF1 RF00026-254 RNU6-166P
GH12J065123 Enhancer 0.5 Ensembl 500.7 -1.3 -1335 0.2 ZSCAN5C PRDM6 KLF1 L3MBTL2 MNT ZSCAN21 WIF1 APOOP3
GH12J064893 Enhancer 0.8 Ensembl ENCODE 18.8 +226.7 226665 3 ZSCAN5C FOS CUX1 GATA3 ZNF184 EZH2 FOXA1 GATA2 JUNB INSM2 WIF1 RNU6-166P RNU6ATAC42P LINC02389 RF00017-1173 RF00004-031
GH12J064900 Enhancer 0.7 Ensembl ENCODE 18.7 +220.7 220695 0.9 CUX1 FOS EZH2 PKNOX1 GATA2 BHLHE40 CEBPB WIF1 RNU6-166P RNU6ATAC42P RF00017-1173 LINC02389 RF00004-031
GH12J064997 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.4 +122.0 122026 3.7 TCF7 FOXA2 CEBPB FOSL2 BCL6 ZFP64 ETV4 ZNF26 TEAD3 CEBPG piR-49423-065 LEMD3 ENSG00000255566 RNU6-166P WIF1 piR-56133-056
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WIF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WIF1

Top Transcription factor binding sites by QIAGEN in the WIF1 gene promoter:
  • AML1a
  • C/EBPalpha
  • Chx10
  • FOXD3
  • Lhx3a
  • LHX3b
  • POU2F1
  • POU2F1a
  • STAT5B

Genomic Locations for WIF1 Gene

Genomic Locations for WIF1 Gene
chr12:65,050,624-65,121,566
(GRCh38/hg38)
Size:
70,943 bases
Orientation:
Minus strand
chr12:65,444,404-65,515,346
(GRCh37/hg19)
Size:
70,943 bases
Orientation:
Minus strand

Genomic View for WIF1 Gene

Genes around WIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIF1 Gene

Proteins for WIF1 Gene

  • Protein details for WIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W5-WIF1_HUMAN
    Recommended name:
    Wnt inhibitory factor 1
    Protein Accession:
    Q9Y5W5
    Secondary Accessions:
    • Q6UXI1
    • Q8WVG4

    Protein attributes for WIF1 Gene

    Size:
    379 amino acids
    Molecular mass:
    41528 Da
    Quaternary structure:
    • Interacts with MYOC.

    Three dimensional structures from OCA and Proteopedia for WIF1 Gene

neXtProt entry for WIF1 Gene

Post-translational modifications for WIF1 Gene

  • Glycosylation at Asn88 and Asn245
  • Modification sites at PhosphoSitePlus

Other Protein References for WIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WIF1 Gene

Domains & Families for WIF1 Gene

Gene Families for WIF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WIF1 Gene

Blocks:
  • Type I EGF
  • WIF domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WIF1 Gene

GenScript: Design optimal peptide antigens:
  • Wnt inhibitory factor 1 (WIF1_HUMAN)
genes like me logo Genes that share domains with WIF1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WIF1 Gene

Function for WIF1 Gene

Molecular function for WIF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Phenotypes From GWAS Catalog for WIF1 Gene

Gene Ontology (GO) - Molecular Function for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IPI 19188438
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with WIF1: view
genes like me logo Genes that share phenotypes with WIF1: view

Animal Models for WIF1 Gene

MGI Knock Outs for WIF1:
  • Wif1 Wif1<tm1Dmth>

Animal Model Products

  • Taconic Biosciences Mouse Models for WIF1

CRISPR Products

miRNA for WIF1 Gene

Clone Products

  • Addgene plasmids for WIF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WIF1 Gene

Localization for WIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIF1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA 21873635
GO:0009986 cell surface IBA 21873635
genes like me logo Genes that share ontologies with WIF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WIF1 Gene

Pathways & Interactions for WIF1 Gene

genes like me logo Genes that share pathways with WIF1: view

Pathways by source for WIF1 Gene

1 Qiagen pathway for WIF1 Gene
  • WNT Signaling
1 Cell Signaling Technology pathway for WIF1 Gene
1 GeneTex pathway for WIF1 Gene

SIGNOR curated interactions for WIF1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10201374
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway NAS 24431302
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with WIF1: view

Drugs & Compounds for WIF1 Gene

(2) Drugs for WIF1 Gene - From: PharmGKB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
KY 02111 Pharma WNT signaling inhibitor 0

(1) Additional Compounds for WIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for WIF1 Gene

Compound Action Cas Number
KY 02111 WNT signaling inhibitor 1118807-13-8
genes like me logo Genes that share compounds with WIF1: view

Transcripts for WIF1 Gene

mRNA/cDNA for WIF1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for WIF1

Alternative Splicing Database (ASD) splice patterns (SP) for WIF1 Gene

No ASD Table

Relevant External Links for WIF1 Gene

GeneLoc Exon Structure for
WIF1

Expression for WIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WIF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIF1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.9), Brain - Caudate (basal ganglia) (x8.7), Brain - Putamen (basal ganglia) (x7.1), and Brain - Amygdala (x6.3).

Protein differential expression in normal tissues from HIPED for WIF1 Gene

This gene is overexpressed in Vitreous humor (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WIF1 Gene



Protein tissue co-expression partners for WIF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WIF1

SOURCE GeneReport for Unigene cluster for WIF1 Gene:

Hs.284122

Evidence on tissue expression from TISSUES for WIF1 Gene

  • Nervous system(4.9)
  • Lung(2.7)
  • Eye(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with WIF1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIF1 Gene

Orthologs for WIF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIF1 31 30
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WIF1 31
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WIF1 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIF1 31 30
  • 91.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wif1 30
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Wif1 17 31 30
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WIF1 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIF1 31 30
  • 77.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIF1 31
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wif1 30
  • 78.02 (n)
Str.5672 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.480 30
zebrafish
(Danio rerio)
Actinopterygii wif1 31 30 30
  • 68.72 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shf 31 30
  • 47.79 (n)
OneToMany
CG3135 32
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000117 30
  • 47.37 (n)
worm
(Caenorhabditis elegans)
Secernentea T01D3.1 31
  • 3 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
ManyToMany
-- 31
  • 3 (a)
ManyToMany
-- 31
  • 2 (a)
ManyToMany
Species where no ortholog for WIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIF1 Gene

ENSEMBL:
Gene Tree for WIF1 (if available)
TreeFam:
Gene Tree for WIF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WIF1: view image

Paralogs for WIF1 Gene

Paralogs for WIF1 Gene

(3) SIMAP similar genes for WIF1 Gene using alignment to 3 proteins:

  • WIF1_HUMAN
  • F5H8A3_HUMAN
  • H0YFK7_HUMAN
genes like me logo Genes that share paralogs with WIF1: view

Variants for WIF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WIF1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
710452 Benign: not provided 65,051,408(-) G/T MISSENSE_VARIANT
712180 Likely Benign: not provided 65,055,155(-) T/C SYNONYMOUS_VARIANT
733506 Benign: not provided 65,120,461(-) C/G MISSENSE_VARIANT
746947 Benign: not provided 65,051,385(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WIF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for WIF1 Gene

Variant ID Type Subtype PubMed ID
esv3306300 CNV mobile element insertion 20981092
esv3389043 CNV insertion 20981092
esv3629788 CNV loss 21293372
nsv1053931 CNV gain 25217958
nsv469458 CNV gain 19166990
nsv510299 OTHER sequence alteration 20534489
nsv559205 CNV gain 21841781
nsv832445 CNV gain 17160897

Variation tolerance for WIF1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIF1 Gene

Human Gene Mutation Database (HGMD)
WIF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIF1 Gene

Disorders for WIF1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for WIF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
adenoid cystic carcinoma
  • salivary gland adenoid cystic carcinoma
holoprosencephaly
  • holoprosencephaly sequence
lung cancer
  • adenocarcinoma of lung
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search WIF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WIF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIF1 Gene

Publications for WIF1 Gene

  1. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S … Weiss ST (American journal of respiratory and critical care medicine 2010) 3 23 41 54
  2. NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. (PMID: 16476441) Liepinsh E … Otting G (Journal of molecular biology 2006) 3 4 23 54
  3. A new secreted protein that binds to Wnt proteins and inhibits their activities. (PMID: 10201374) Hsieh JC … Nathans J (Nature 1999) 2 3 4 54
  4. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PMID: 22504421) Bis JC … Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (Nature genetics 2012) 3 41 54
  5. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PMID: 20844743) Fernández-Rozadilla C … Gastrointestinal Oncology Group of the Spanish Gastroenterological Association (PloS one 2010) 3 41 54

Products for WIF1 Gene

Sources for WIF1 Gene