External Ids for WIF1 Gene
Previous GeneCards Identifiers for WIF1 Gene
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
GeneCards Summary for WIF1 Gene
WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Colorectal Cancer and Adenoid Cystic Carcinoma. Among its related pathways are Signaling by Wnt and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. An important paralog of this gene is DLL3.
UniProtKB/Swiss-Prot Summary for WIF1 Gene
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.