External Ids for WIF1 Gene
Previous GeneCards Identifiers for WIF1 Gene
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
GeneCards Summary for WIF1 Gene
WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Esophageal Basaloid Squamous Cell Carcinoma and Colorectal Cancer. Among its related pathways are Presenilin action in Notch and Wnt signaling and Wnt/beta-catenin Signaling Pathway in Leukemia. An important paralog of this gene is VWDE.
UniProtKB/Swiss-Prot for WIF1 Gene
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.