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Aliases for WIF1 Gene

Aliases for WIF1 Gene

  • WNT Inhibitory Factor 1 2 3 5
  • WIF-1 3 4
  • Wnt Inhibitory Factor 1 3

External Ids for WIF1 Gene

Previous GeneCards Identifiers for WIF1 Gene

  • GC12P064885
  • GC12P065390
  • GC12M065161
  • GC12M063730
  • GC12M065444
  • GC12M062496

Summaries for WIF1 Gene

Entrez Gene Summary for WIF1 Gene

  • The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

GeneCards Summary for WIF1 Gene

WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Esophageal Basaloid Squamous Cell Carcinoma and Gastrointestinal System Benign Neoplasm. Among its related pathways are Signaling by Wnt and Wnt signaling network. An important paralog of this gene is VWDE.

UniProtKB/Swiss-Prot for WIF1 Gene

  • Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Gene Wiki entry for WIF1 Gene

Additional gene information for WIF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIF1 Gene

Genomics for WIF1 Gene

GeneHancer (GH) Regulatory Elements for WIF1 Gene

Promoters and enhancers for WIF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J065121 Promoter/Enhancer 1.2 EPDnew ENCODE 650.7 +0.3 270 0.2 CTCF MXI1 ZNF777 ZNF792 SUZ12 HIC1 ZNF335 ZFHX2 GLIS2 POLR2A WIF1 RNU6-166P
GH12J065122 Promoter 1 EPDnew 650.7 0.0 -15 0.1 CTCF SUZ12 HIC1 ZNF335 ZFHX2 GLIS2 PATZ1 EZH2 ZNF501 ZBTB8A WIF1 APOOP3
GH12J064895 Enhancer 0.5 ENCODE 18.8 +225.9 225904 1.1 GATA3 BCL6B CREB1 JUNB FOS CUX1 FOXA1 WIF1 RNU6-166P RNU6ATAC42P LINC02389 GC12P064940
GH12J064900 Enhancer 0.4 ENCODE 18.7 +220.7 220695 0.9 PKNOX1 FOS CUX1 WIF1 RNU6-166P RNU6ATAC42P LINC02389 GC12P064940
GH12J064997 Enhancer 0.7 ENCODE dbSUPER 9.4 +122.4 122374 3 FOXA2 ETV4 CEBPA ZFP64 TCF7 ETV5 TEAD3 RNU6-166P WIF1 LINC02231 ENSG00000198671
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WIF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WIF1 gene promoter:
  • C/EBPalpha
  • POU2F1a
  • POU2F1
  • Chx10
  • STAT5B
  • AML1a
  • FOXD3
  • Lhx3a
  • LHX3b

Regulatory Element Products

Genomic Locations for WIF1 Gene

Genomic Locations for WIF1 Gene
70,943 bases
Minus strand
70,943 bases
Minus strand

Genomic View for WIF1 Gene

Genes around WIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIF1 Gene

Proteins for WIF1 Gene

  • Protein details for WIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Wnt inhibitory factor 1
    Protein Accession:
    Secondary Accessions:
    • Q6UXI1
    • Q8WVG4

    Protein attributes for WIF1 Gene

    379 amino acids
    Molecular mass:
    41528 Da
    Quaternary structure:
    • Interacts with MYOC.

    Three dimensional structures from OCA and Proteopedia for WIF1 Gene

neXtProt entry for WIF1 Gene

Post-translational modifications for WIF1 Gene

  • Glycosylation at isoforms=245 and isoforms=88
  • Modification sites at PhosphoSitePlus

Other Protein References for WIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Abcam proteins for WIF1

No data available for DME Specific Peptides for WIF1 Gene

Domains & Families for WIF1 Gene

Gene Families for WIF1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WIF1 Gene

Suggested Antigen Peptide Sequences for WIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WIF1: view

No data available for UniProtKB/Swiss-Prot for WIF1 Gene

Function for WIF1 Gene

Molecular function for WIF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Phenotypes From GWAS Catalog for WIF1 Gene

Gene Ontology (GO) - Molecular Function for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19188438
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with WIF1: view
genes like me logo Genes that share phenotypes with WIF1: view

Animal Models for WIF1 Gene

MGI Knock Outs for WIF1:
  • Wif1 Wif1<tm1Dmth>

Animal Model Products

  • Taconic Biosciences Mouse Models for WIF1

miRNA for WIF1 Gene

Clone Products

  • Addgene plasmids for WIF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WIF1 Gene

Localization for WIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIF1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIF1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WIF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WIF1 Gene

Pathways & Interactions for WIF1 Gene

genes like me logo Genes that share pathways with WIF1: view

Pathways by source for WIF1 Gene

1 Qiagen pathway for WIF1 Gene
1 Cell Signaling Technology pathway for WIF1 Gene

SIGNOR curated interactions for WIF1 Gene


Gene Ontology (GO) - Biological Process for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10201374
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway NAS 24431302
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with WIF1: view

Drugs & Compounds for WIF1 Gene

(2) Drugs for WIF1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
KY 02111 Pharma WNT signaling inhibitor 0

(1) Additional Compounds for WIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WIF1: view

Transcripts for WIF1 Gene

mRNA/cDNA for WIF1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WIF1 Gene

WNT inhibitory factor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for WIF1

Alternative Splicing Database (ASD) splice patterns (SP) for WIF1 Gene

No ASD Table

Relevant External Links for WIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WIF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIF1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.9), Brain - Caudate (basal ganglia) (x8.7), Brain - Putamen (basal ganglia) (x7.1), and Brain - Amygdala (x6.3).

Protein differential expression in normal tissues from HIPED for WIF1 Gene

This gene is overexpressed in Vitreous humor (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WIF1 Gene

Protein tissue co-expression partners for WIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WIF1 Gene:


SOURCE GeneReport for Unigene cluster for WIF1 Gene:


Evidence on tissue expression from TISSUES for WIF1 Gene

  • Nervous system(4.9)
  • Lung(2.7)
  • Eye(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with WIF1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIF1 Gene

Orthologs for WIF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WIF1 34 33
  • 99.56 (n)
(Bos Taurus)
Mammalia WIF1 34
  • 93 (a)
(Monodelphis domestica)
Mammalia WIF1 34
  • 92 (a)
(Canis familiaris)
Mammalia WIF1 34 33
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Wif1 33
  • 89.5 (n)
(Mus musculus)
Mammalia Wif1 16 34 33
  • 88.48 (n)
(Ornithorhynchus anatinus)
Mammalia WIF1 34
  • 85 (a)
(Gallus gallus)
Aves WIF1 34 33
  • 77.81 (n)
(Anolis carolinensis)
Reptilia WIF1 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wif1 33
  • 78.02 (n)
Str.5672 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.480 33
(Danio rerio)
Actinopterygii wif1 34 33 33
  • 68.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta shf 34 33
  • 47.79 (n)
CG3135 35
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000117 33
  • 47.37 (n)
(Caenorhabditis elegans)
Secernentea T01D3.1 34
  • 3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
-- 34
  • 3 (a)
-- 34
  • 2 (a)
Species where no ortholog for WIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIF1 Gene

Gene Tree for WIF1 (if available)
Gene Tree for WIF1 (if available)
Evolutionary constrained regions (ECRs) for WIF1: view image

Paralogs for WIF1 Gene

Paralogs for WIF1 Gene

(3) SIMAP similar genes for WIF1 Gene using alignment to 3 proteins:

  • F5H8A3_HUMAN
genes like me logo Genes that share paralogs with WIF1: view

Variants for WIF1 Gene

Sequence variations from dbSNP and Humsavar for WIF1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000153166 -- 65,080,694(-) C/G intron_variant
rs1000155052 -- 65,121,589(-) A/G upstream_transcript_variant
rs1000206000 -- 65,090,490(-) A/C intron_variant
rs1000261400 -- 65,066,199(-) T/C intron_variant
rs1000274666 -- 65,120,742(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WIF1 Gene

Variant ID Type Subtype PubMed ID
esv3306300 CNV mobile element insertion 20981092
esv3389043 CNV insertion 20981092
esv3629788 CNV loss 21293372
nsv1053931 CNV gain 25217958
nsv469458 CNV gain 19166990
nsv510299 OTHER sequence alteration 20534489
nsv559205 CNV gain 21841781
nsv832445 CNV gain 17160897

Variation tolerance for WIF1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WIF1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIF1 Gene

Disorders for WIF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WIF1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
gastrointestinal system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search WIF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WIF1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIF1 Gene

Publications for WIF1 Gene

  1. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S … Weiss ST (American journal of respiratory and critical care medicine 2010) 3 22 44 58
  2. NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. (PMID: 16476441) Liepinsh E … Otting G (Journal of molecular biology 2006) 3 4 22 58
  3. A new secreted protein that binds to Wnt proteins and inhibits their activities. (PMID: 10201374) Hsieh JC … Nathans J (Nature 1999) 2 3 4 58
  4. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PMID: 22504421) Bis JC … Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (Nature genetics 2012) 3 44 58
  5. Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas. (PMID: 20334650) Yang Z … Wang Y (Journal of experimental & clinical cancer research : CR 2010) 3 22 58

Products for WIF1 Gene

Sources for WIF1 Gene

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