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Aliases for WFDC9 Gene

Aliases for WFDC9 Gene

  • WAP Four-Disulfide Core Domain 9 2 3 5
  • WAP9 3 4
  • Protein WFDC9 3
  • DJ688G8.2 3

External Ids for WFDC9 Gene

Previous GeneCards Identifiers for WFDC9 Gene

  • GC20M043925
  • GC20M044875
  • GC20M044922
  • GC20M043669
  • GC20M044236
  • GC20M040978

Summaries for WFDC9 Gene

Entrez Gene Summary for WFDC9 Gene

  • The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC9 Gene

WFDC9 (WAP Four-Disulfide Core Domain 9) is a Protein Coding gene. An important paralog of this gene is WFDC11.

Additional gene information for WFDC9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC9 Gene

Genomics for WFDC9 Gene

GeneHancer (GH) Regulatory Elements for WFDC9 Gene

Promoters and enhancers for WFDC9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045629 Enhancer 0.7 ENCODE 550.8 +1.6 1591 0.2 SMARCA5 CTCF USF1 TRIM22 MAX ELF1 RAD21 GATA3 ZNF366 CREB1 WFDC9 WFDC10A
GH20I045631 Promoter 0.5 EPDnew 550.8 +0.0 4 0.1 WFDC9 WFDC10A
GH20I045610 Enhancer 0.6 ENCODE 0.4 +19.9 19923 1.6 MAZ RFX1 HLF CEBPG GABPA ZNF148 ZFHX2 GATA3 EGR1 VEZF1 WFDC3 WFDC13 ENSG00000237464 WFDC10A WFDC9 WFDC8
GH20I045641 Promoter 0.5 Ensembl 0.4 -10.0 -10033 0.2 RPS2P7 WFDC3 WFDC13 WFDC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WFDC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC9 gene promoter:

Genomic Locations for WFDC9 Gene

Genomic Locations for WFDC9 Gene
23,330 bases
Minus strand

Genomic View for WFDC9 Gene

Genes around WFDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC9 Gene

Proteins for WFDC9 Gene

  • Protein details for WFDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WFDC9
    Protein Accession:
    Secondary Accessions:
    • Q3MIX6
    • Q5TGZ8

    Protein attributes for WFDC9 Gene

    89 amino acids
    Molecular mass:
    10506 Da
    Quaternary structure:
    No Data Available
    • Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

neXtProt entry for WFDC9 Gene

Post-translational modifications for WFDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC9 Gene

Domains & Families for WFDC9 Gene

Gene Families for WFDC9 Gene

Protein Domains for WFDC9 Gene


Suggested Antigen Peptide Sequences for WFDC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC9: view

No data available for UniProtKB/Swiss-Prot for WFDC9 Gene

Function for WFDC9 Gene

Gene Ontology (GO) - Molecular Function for WFDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WFDC9: view

Phenotypes for WFDC9 Gene

genes like me logo Genes that share phenotypes with WFDC9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC9 Gene

Localization for WFDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC9 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC9 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC9 Gene

Pathways & Interactions for WFDC9 Gene

SuperPathways for WFDC9 Gene

No Data Available

Interacting Proteins for WFDC9 Gene

Selected Interacting proteins: Q8NEX5-WFDC9_HUMAN for WFDC9 Gene via IID UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC9 Gene


No data available for Pathways by source and SIGNOR curated interactions for WFDC9 Gene

Drugs & Compounds for WFDC9 Gene

No Compound Related Data Available

Transcripts for WFDC9 Gene

mRNA/cDNA for WFDC9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC9 Gene

WAP four-disulfide core domain 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC9 Gene

No ASD Table

Relevant External Links for WFDC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC9 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC9 Gene:


SOURCE GeneReport for Unigene cluster for WFDC9 Gene:


Evidence on tissue expression from TISSUES for WFDC9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with WFDC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC9 Gene

Orthologs for WFDC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC9 33 34
  • 98.88 (n)
(Canis familiaris)
Mammalia LOC100685852 33
  • 77.15 (n)
WFDC9 34
  • 67 (a)
(Rattus norvegicus)
Mammalia Wfdc9 33
  • 70.27 (n)
(Mus musculus)
Mammalia Wfdc9 33 16 34
  • 68.29 (n)
(Bos Taurus)
Mammalia WFDC9 34
  • 57 (a)
Species where no ortholog for WFDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC9 Gene

Gene Tree for WFDC9 (if available)
Gene Tree for WFDC9 (if available)

Paralogs for WFDC9 Gene

Paralogs for WFDC9 Gene

(2) SIMAP similar genes for WFDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC9: view

Variants for WFDC9 Gene

Sequence variations from dbSNP and Humsavar for WFDC9 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000004976 -- 45,617,776(-) A/G intron_variant
rs1000050999 -- 45,631,896(-) A/G upstream_transcript_variant
rs1000105092 -- 45,624,351(-) C/T intron_variant
rs1000119134 -- 45,630,272(-) T/C intron_variant
rs1000402050 -- 45,631,554(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC9 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv586081 CNV loss 21841781
nsv7342 OTHER inversion 18451855

Variation tolerance for WFDC9 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC9 Gene

Disorders for WFDC9 Gene

Additional Disease Information for WFDC9

No disorders were found for WFDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC9 Gene

Publications for WFDC9 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for WFDC9 Gene

Sources for WFDC9 Gene

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