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Aliases for WFDC8 Gene

Aliases for WFDC8 Gene

  • WAP Four-Disulfide Core Domain 8 2 3 5
  • Putative Protease Inhibitor WAP8 3 4
  • C20orf170 3 4
  • WAP8 3 4
  • WAP Four-Disulfide Core Domain Protein 8 3
  • Chromosome 20 Open Reading Frame 170 2
  • Epididymis Secretory Protein Li 292 3
  • Testicular Secretory Protein Li 68 3
  • Protease Inhibitor WAP8 3
  • WAP Motif Protein 1 3
  • DJ461P17.1 3
  • HEL-S-292 3

External Ids for WFDC8 Gene

Previous HGNC Symbols for WFDC8 Gene

  • C20orf170

Previous GeneCards Identifiers for WFDC8 Gene

  • GC20M043868
  • GC20M044818
  • GC20M044865
  • GC20M043613
  • GC20M044179
  • GC20M040921

Summaries for WFDC8 Gene

Entrez Gene Summary for WFDC8 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC8 Gene

WFDC8 (WAP Four-Disulfide Core Domain 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is EPPIN-WFDC6.

Additional gene information for WFDC8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC8 Gene

Genomics for WFDC8 Gene

GeneHancer (GH) Regulatory Elements for WFDC8 Gene

Promoters and enhancers for WFDC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045579 Promoter 0.5 EPDnew 550.8 +0.0 47 0.1 WFDC8 CCNB1IP1P2
GH20I045578 Enhancer 0.2 ENCODE 550.8 +1.0 955 0.5 WFDC8 CCNB1IP1P2
GH20I045429 Enhancer 0.2 dbSUPER 4.9 +149.7 149722 1.3 SYS1-DBNDD2 SYS1 PIGT WFDC8 ENSG00000237464 LOC105372631 GC20P045440
GH20I045610 Enhancer 0.6 ENCODE 0.3 -32.0 -31995 1.6 MAZ RFX1 HLF CEBPG GABPA ZNF148 ZFHX2 GATA3 EGR1 VEZF1 WFDC3 WFDC13 ENSG00000237464 WFDC10A WFDC9 WFDC8
GH20I045583 Enhancer 0.2 ENCODE 0.8 -4.4 -4427 0.2 WFDC8 WFDC10A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WFDC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC8 gene promoter:

Genomic Locations for WFDC8 Gene

Genomic Locations for WFDC8 Gene
28,199 bases
Minus strand

Genomic View for WFDC8 Gene

Genes around WFDC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC8 Gene

Proteins for WFDC8 Gene

  • Protein details for WFDC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 8
    Protein Accession:
    Secondary Accessions:
    • E1P623
    • Q5TDV2
    • Q96A34

    Protein attributes for WFDC8 Gene

    241 amino acids
    Molecular mass:
    27824 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC8 Gene

Post-translational modifications for WFDC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC8 Gene

No data available for DME Specific Peptides for WFDC8 Gene

Domains & Families for WFDC8 Gene

Gene Families for WFDC8 Gene

Suggested Antigen Peptide Sequences for WFDC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC8: view

No data available for UniProtKB/Swiss-Prot for WFDC8 Gene

Function for WFDC8 Gene

Gene Ontology (GO) - Molecular Function for WFDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC8: view
genes like me logo Genes that share phenotypes with WFDC8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC8

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC8 Gene

Localization for WFDC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC8 gene
Compartment Confidence
extracellular 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for WFDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC8 Gene

Pathways & Interactions for WFDC8 Gene

SuperPathways for WFDC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC8: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC8 Gene

Drugs & Compounds for WFDC8 Gene

No Compound Related Data Available

Transcripts for WFDC8 Gene

mRNA/cDNA for WFDC8 Gene

Unigene Clusters for WFDC8 Gene

WAP four-disulfide core domain 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC8 Gene

No ASD Table

Relevant External Links for WFDC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC8 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC8 Gene

This gene is overexpressed in Thyroid (x9.5), Testis (x8.2), and Cervix - Endocervix (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of WFDC8 Gene:


SOURCE GeneReport for Unigene cluster for WFDC8 Gene:


mRNA Expression by UniProt/SwissProt for WFDC8 Gene:

Tissue specificity: Expressed ubiquitously, the highest levels are found in the epididymis followed by testis and trachea.
genes like me logo Genes that share expression patterns with WFDC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC8 Gene

Orthologs for WFDC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFDC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC8 33 34
  • 98.48 (n)
(Canis familiaris)
Mammalia LOC477245 33
  • 75.29 (n)
WFDC8 34
  • 63 (a)
(Bos Taurus)
Mammalia WFDC8 33 34
  • 73.53 (n)
(Mus musculus)
Mammalia Wfdc8 33 16 34
  • 67.63 (n)
(Rattus norvegicus)
Mammalia Wfdc8 33
  • 66.81 (n)
(Monodelphis domestica)
Mammalia WFDC8 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
-- 34
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
-- 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3604 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea R12A1.3 34
  • 20 (a)
Species where no ortholog for WFDC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for WFDC8 Gene

Gene Tree for WFDC8 (if available)
Gene Tree for WFDC8 (if available)

Paralogs for WFDC8 Gene

Paralogs for WFDC8 Gene

(6) SIMAP similar genes for WFDC8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC8: view

Variants for WFDC8 Gene

Sequence variations from dbSNP and Humsavar for WFDC8 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000202876 -- 45,552,584(-) C/A 3_prime_UTR_variant, intron_variant
rs1000206760 -- 45,577,020(-) C/T intron_variant
rs1000253746 -- 45,552,943(-) G/C 3_prime_UTR_variant, intron_variant
rs1000431424 -- 45,570,400(-) A/C intron_variant
rs1000841040 -- 45,558,508(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC8 Gene

Variant ID Type Subtype PubMed ID
dgv7587n54 CNV loss 21841781
dgv7588n54 CNV loss 21841781
dgv7589n54 CNV loss 21841781
esv25639 CNV loss 19812545
esv2661076 CNV deletion 23128226
esv2722448 CNV deletion 23290073
esv32588 CNV loss 17666407
esv3557118 CNV deletion 23714750
esv3645933 CNV loss 21293372
esv3645935 CNV loss 21293372
nsv1056102 CNV loss 25217958
nsv586080 CNV loss 21841781
nsv586081 CNV loss 21841781
nsv586113 CNV loss 21841781
nsv819057 CNV gain 19587683

Variation tolerance for WFDC8 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC8 Gene

Disorders for WFDC8 Gene

Additional Disease Information for WFDC8

No disorders were found for WFDC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC8 Gene

Publications for WFDC8 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z … Hurle B (Molecular biology and evolution 2013) 3 58
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58
  5. Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. (PMID: 21536719) Ferreira Z … Seixas S (Molecular biology and evolution 2011) 3 58

Products for WFDC8 Gene

Sources for WFDC8 Gene

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