Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WFDC6 Gene

Aliases for WFDC6 Gene

  • WAP Four-Disulfide Core Domain 6 2 3 5
  • C20orf171 3 4
  • WAP6 3 4
  • WAP Four-Disulfide Core Domain Protein 6 3
  • Chromosome 20 Open Reading Frame 171 2
  • Epididymis Secretory Protein Li 295 3
  • Putative Protease Inhibitor WAP6 4
  • Protease Inhibitor WAP6 3
  • DJ461P17.11 3
  • HEL-S-295 3

External Ids for WFDC6 Gene

Previous HGNC Symbols for WFDC6 Gene

  • C20orf171

Previous GeneCards Identifiers for WFDC6 Gene

  • GC20M043851
  • GC20M044801
  • GC20M044848
  • GC20M043596
  • GC20M044162
  • GC20M040904

Summaries for WFDC6 Gene

Entrez Gene Summary for WFDC6 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for WFDC6 Gene

WFDC6 (WAP Four-Disulfide Core Domain 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is EPPIN.

Additional gene information for WFDC6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC6 Gene

Genomics for WFDC6 Gene

GeneHancer (GH) Regulatory Elements for WFDC6 Gene

Promoters and enhancers for WFDC6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045539 Promoter 0.5 EPDnew 550.8 0.0 -6 0.1 HSPD1P21 WFDC6 EPPIN-WFDC6
GH20I045538 Enhancer 0.4 ENCODE 550.8 +0.9 938 0 ZNF143 FOS ENSG00000232135 HSPD1P21 WFDC6 EPPIN-WFDC6
GH20I045770 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.3 -231.8 -231842 1.1 CLOCK FOXA2 MLX ARID4B SLC30A9 ARID2 ZNF143 DEK RXRA NCOA1 WFDC3 WFDC13 SPINT5P HNRNPA1P3 DNTTIP1 EPPIN EPPIN-WFDC6 ENSG00000232135 HSPD1P21 WFDC6
GH20I045765 Enhancer 0.3 ENCODE 10.3 -226.9 -226908 2.6 POLR2A WFDC3 WFDC13 DNTTIP1 HNRNPA1P3 EPPIN EPPIN-WFDC6 ENSG00000232135 HSPD1P21 WFDC6 SPINT3
GH20I045773 Enhancer 0.3 dbSUPER 10.3 -235.6 -235576 2.6 EGR2 GC20P045773 WFDC3 UBE2C SNX21 TNNC2 EPPIN EPPIN-WFDC6 HSPD1P21 ENSG00000232135 WFDC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WFDC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC6 gene promoter:

Genomic Locations for WFDC6 Gene

Genomic Locations for WFDC6 Gene
5,300 bases
Minus strand

Genomic View for WFDC6 Gene

Genes around WFDC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC6 Gene

Proteins for WFDC6 Gene

  • Protein details for WFDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 6
    Protein Accession:
    Secondary Accessions:
    • Q3MJ23
    • Q5JYQ4
    • Q8NFV6

    Protein attributes for WFDC6 Gene

    131 amino acids
    Molecular mass:
    14626 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC6 Gene


neXtProt entry for WFDC6 Gene

Post-translational modifications for WFDC6 Gene

No Post-translational modifications

Other Protein References for WFDC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC6 Gene

Domains & Families for WFDC6 Gene

Gene Families for WFDC6 Gene

Protein Domains for WFDC6 Gene

Suggested Antigen Peptide Sequences for WFDC6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC6: view

No data available for UniProtKB/Swiss-Prot for WFDC6 Gene

Function for WFDC6 Gene

Gene Ontology (GO) - Molecular Function for WFDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC6: view
genes like me logo Genes that share phenotypes with WFDC6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC6 Gene

Localization for WFDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC6 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for WFDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC6 Gene

Pathways & Interactions for WFDC6 Gene

SuperPathways for WFDC6 Gene

No Data Available

Interacting Proteins for WFDC6 Gene

Gene Ontology (GO) - Biological Process for WFDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC6: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC6 Gene

Drugs & Compounds for WFDC6 Gene

No Compound Related Data Available

Transcripts for WFDC6 Gene

mRNA/cDNA for WFDC6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC6 Gene

WAP four-disulfide core domain 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC6 Gene

No ASD Table

Relevant External Links for WFDC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC6 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC6 Gene

This gene is overexpressed in Testis (x45.5).

Protein differential expression in normal tissues from HIPED for WFDC6 Gene

This gene is overexpressed in Testis (53.4) and Ovary (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFDC6 Gene

Protein tissue co-expression partners for WFDC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WFDC6 Gene:


SOURCE GeneReport for Unigene cluster for WFDC6 Gene:


mRNA Expression by UniProt/SwissProt for WFDC6 Gene:

Tissue specificity: Ubiquitously expressed, but the highest levels are found in epididymis, testis and trachea.

Evidence on tissue expression from TISSUES for WFDC6 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with WFDC6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC6 Gene

Orthologs for WFDC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFDC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Wfdc6a 34
  • 34 (a)
Wfdc6b 34
  • 28 (a)
(Canis familiaris)
Mammalia WFDC6 34
  • 32 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 16 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 13 (a)
-- 34
  • 11 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 12 (a)
-- 34
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3604 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea R12A1.3 34
  • 5 (a)
Species where no ortholog for WFDC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for WFDC6 Gene

Gene Tree for WFDC6 (if available)
Gene Tree for WFDC6 (if available)

Paralogs for WFDC6 Gene

Paralogs for WFDC6 Gene

(1) SIMAP similar genes for WFDC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WFDC6: view

Variants for WFDC6 Gene

Sequence variations from dbSNP and Humsavar for WFDC6 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000272523 -- 45,535,177(-) G/T intron_variant
rs1000722292 -- 45,535,497(-) T/C intron_variant
rs1001416692 -- 45,541,372(-) A/G upstream_transcript_variant
rs1001432665 -- 45,535,588(-) C/T intron_variant
rs1003458473 -- 45,538,864(-) TGTG/TG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC6 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for WFDC6 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC6 Gene

Disorders for WFDC6 Gene

Additional Disease Information for WFDC6

No disorders were found for WFDC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC6 Gene

Publications for WFDC6 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z … Hurle B (Molecular biology and evolution 2013) 3 58
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A … Lundwall A (Biochemical and biophysical research communications 2005) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for WFDC6 Gene

Sources for WFDC6 Gene

Loading form....