This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encod... See more...

Aliases for WFDC2 Gene

Aliases for WFDC2 Gene

  • WAP Four-Disulfide Core Domain 2 2 3 5
  • WAP5 2 3 4
  • HE4 2 3 4
  • WAP Four-Disulfide Core Domain Protein 2 3 4
  • Major Epididymis-Specific Protein E4 3 4
  • Putative Protease Inhibitor WAP5 3 4
  • Epididymal Secretory Protein E4 3 4
  • Epididymal Protein 4 2 3
  • DJ461P17.6 2 3
  • EDDM4 2 3
  • Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core 3
  • Epididymis Secretory Sperm Binding Protein 3
  • WAP Domain Containing Protein HE4-V4 3
  • WFDC2 5

External Ids for WFDC2 Gene

Previous GeneCards Identifiers for WFDC2 Gene

  • GC20P043826
  • GC20P044736
  • GC20P044783
  • GC20P043532
  • GC20P044098
  • GC20P040839
  • GC20P045448

Summaries for WFDC2 Gene

Entrez Gene Summary for WFDC2 Gene

  • This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC2 Gene

WFDC2 (WAP Four-Disulfide Core Domain 2) is a Protein Coding gene. Diseases associated with WFDC2 include Fallopian Tube Carcinoma and Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot Summary for WFDC2 Gene

Gene Wiki entry for WFDC2 Gene

Additional gene information for WFDC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WFDC2 Gene

Genomics for WFDC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WFDC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WFDC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WFDC2

Top Transcription factor binding sites by QIAGEN in the WFDC2 gene promoter:
  • COMP1
  • IRF-1
  • Nkx2-5
  • Pax-2
  • Pax-2a
  • Pax-6
  • Sp1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for WFDC2 Gene

Genomic Locations for WFDC2 Gene
chr20:45,469,753-45,481,532
(GRCh38/hg38)
Size:
11,780 bases
Orientation:
Plus strand
chr20:44,098,346-44,110,172
(GRCh37/hg19)
Size:
11,827 bases
Orientation:
Plus strand

Genomic View for WFDC2 Gene

Genes around WFDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC2 Gene

Proteins for WFDC2 Gene

  • Protein details for WFDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14508-WFDC2_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 2
    Protein Accession:
    Q14508
    Secondary Accessions:
    • A2A2A5
    • A2A2A6
    • A6PVD5
    • Q6IB27
    • Q8WXV9
    • Q8WXW0
    • Q8WXW1
    • Q8WXW2
    • Q96KJ1

    Protein attributes for WFDC2 Gene

    Size:
    124 amino acids
    Molecular mass:
    12993 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked.

    Alternative splice isoforms for WFDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WFDC2 Gene

Post-translational modifications for WFDC2 Gene

  • Glycosylation at Asn44
  • Glycosylation from GlyConnect
    • WFDC2_HUMAN (1902)

Other Protein References for WFDC2 Gene

Antibody Products

  • Abcam antibodies for WFDC2
  • Santa Cruz Biotechnology (SCBT) Antibodies for WFDC2

No data available for DME Specific Peptides for WFDC2 Gene

Domains & Families for WFDC2 Gene

Gene Families for WFDC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WFDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76533, highly similar to Homo sapiens WAP four-disulfide core domain 2 (WFDC2), transcript variant 3, mRNA (A8K2M3_HUMAN)
  • Putative protease inhibitor WAP5 (WFDC2_HUMAN)
genes like me logo Genes that share domains with WFDC2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WFDC2 Gene

Function for WFDC2 Gene

Molecular function for WFDC2 Gene

UniProtKB/Swiss-Prot Function:
Broad range protease inhibitor.

Phenotypes From GWAS Catalog for WFDC2 Gene

Gene Ontology (GO) - Molecular Function for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 1686187
GO:0004867 serine-type endopeptidase inhibitor activity IDA 23139753
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 25362534
GO:0019828 aspartic-type endopeptidase inhibitor activity IDA 23139753
genes like me logo Genes that share ontologies with WFDC2: view
genes like me logo Genes that share phenotypes with WFDC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WFDC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC2 Gene

Localization for WFDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC2 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with WFDC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC2 Gene

Pathways & Interactions for WFDC2 Gene

PathCards logo

SuperPathways for WFDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 1686187
GO:0007283 spermatogenesis TAS 1686187
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0019731 antibacterial humoral response IBA 21873635
genes like me logo Genes that share ontologies with WFDC2: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC2 Gene

Drugs & Compounds for WFDC2 Gene

(1) Drugs for WFDC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for WFDC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WFDC2: view

Transcripts for WFDC2 Gene

mRNA/cDNA for WFDC2 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WFDC2

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC2 Gene

No ASD Table

Relevant External Links for WFDC2 Gene

GeneLoc Exon Structure for
WFDC2

Expression for WFDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WFDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFDC2 Gene

This gene is overexpressed in Cervix - Endocervix (x11.2), Minor Salivary Gland (x10.2), and Kidney - Cortex (x10.1).

Protein differential expression in normal tissues from HIPED for WFDC2 Gene

This gene is overexpressed in Urine (35.8), Cervix (20.6), and Saliva (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WFDC2 Gene



Protein tissue co-expression partners for WFDC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WFDC2

SOURCE GeneReport for Unigene cluster for WFDC2 Gene:

Hs.2719

mRNA Expression by UniProt/SwissProt for WFDC2 Gene:

Q14508-WFDC2_HUMAN
Tissue specificity: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Evidence on tissue expression from TISSUES for WFDC2 Gene

  • Intestine(4.4)
  • Saliva(4.2)
  • Kidney(2.7)
  • Lung(2.7)
  • Stomach(2.5)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with WFDC2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC2 Gene

Orthologs for WFDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WFDC2 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WFDC2 30 31
  • 83.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wfdc2 30
  • 74.32 (n)
Mouse
(Mus musculus)
Mammalia Wfdc2 30 17 31
  • 74.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WFDC2 30 31
  • 73.98 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WFDC2 31
  • 60 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WFDC2 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WFDC2 31
  • 6 (a)
OneToOne
Species where no ortholog for WFDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for WFDC2 Gene

ENSEMBL:
Gene Tree for WFDC2 (if available)
TreeFam:
Gene Tree for WFDC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WFDC2: view image

Paralogs for WFDC2 Gene

(1) SIMAP similar genes for WFDC2 Gene using alignment to 2 proteins:

  • WFDC2_HUMAN
  • A8K2M3_HUMAN
genes like me logo Genes that share paralogs with WFDC2: view

No data available for Paralogs for WFDC2 Gene

Variants for WFDC2 Gene

Additional dbSNP identifiers (rs#s) for WFDC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WFDC2 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for WFDC2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WFDC2 Gene

Disorders for WFDC2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for WFDC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fallopian tube carcinoma
  • cancer of the fallopian tube
ovarian cancer
  • ovarian cancer, somatic
small intestine lymphoma
  • small intestinal lymphoma
malignant ovarian cyst
endometrium carcinoma in situ
  • carcinoma in situ of endometrium
- elite association - COSMIC cancer census association via MalaCards
Search WFDC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WFDC2

genes like me logo Genes that share disorders with WFDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WFDC2 Gene

Publications for WFDC2 Gene

  1. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. (PMID: 1686187) Kirchhoff C … Krull N (Biology of reproduction 1991) 2 3 4 23
  2. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. (PMID: 15781627) Drapkin R … Hecht JL (Cancer research 2005) 3 4 23
  3. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. (PMID: 12839961) Hellström I … Hellström KE (Cancer research 2003) 3 4 23
  4. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. (PMID: 11965550) Bingle L … Bingle CD (Oncogene 2002) 3 4 23
  5. Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. (PMID: 23139753) Chhikara N … Yadav S (PloS one 2012) 3 4

Products for WFDC2 Gene

Sources for WFDC2 Gene