Aliases for WFDC12 Gene
External Ids for WFDC12 Gene
Previous HGNC Symbols for WFDC12 Gene
Previous GeneCards Identifiers for WFDC12 Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
GeneCards Summary for WFDC12 Gene
WFDC12 (WAP Four-Disulfide Core Domain 12) is a Protein Coding gene. Diseases associated with WFDC12 include Retinitis Pigmentosa 50 and Ichthyosis, Congenital, Autosomal Recessive 1. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is WFDC5.
UniProtKB/Swiss-Prot Summary for WFDC12 Gene
Antibacterial protein. Putative acid-stable proteinase inhibitor.