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Aliases for WFDC10B Gene

Aliases for WFDC10B Gene

  • WAP Four-Disulfide Core Domain 10B 2 3 5
  • WAP12 3 4
  • Protease Inhibitor WAP12 3
  • Protein WFDC10B 3

External Ids for WFDC10B Gene

Previous GeneCards Identifiers for WFDC10B Gene

  • GC20U900001
  • GC20M044951
  • GC20M044998
  • GC20M043746
  • GC20M044314
  • GC20M041054

Summaries for WFDC10B Gene

Entrez Gene Summary for WFDC10B Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC10B Gene

WFDC10B (WAP Four-Disulfide Core Domain 10B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is WFDC10A.

Additional gene information for WFDC10B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC10B Gene

Genomics for WFDC10B Gene

GeneHancer (GH) Regulatory Elements for WFDC10B Gene

Promoters and enhancers for WFDC10B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045704 Promoter 0.5 EPDnew 550.8 +0.3 342 0.1 MIR3617 WFDC10B WFDC13
GH20I045705 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 MIR3617 WFDC10B WFDC13
GH20I045859 Enhancer 0.9 ENCODE 4.9 -156.0 -155956 2.4 PKNOX1 FOXA2 NFIB SREBF2 INSM2 ARID4B KLF17 BRCA1 GTF3C2 ZNF335 WFDC3 PLTP WFDC10B ZSWIM3 GC20M045858
GH20I045863 Enhancer 0.8 ENCODE 4.9 -159.2 -159200 1.1 ELF3 FOXA2 ARID4B RAD21 RARA SLC30A9 SMARCC2 THAP11 MIXL1 HMG20B PLTP WFDC10B ZSWIM3 GC20M045858
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WFDC10B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC10B gene promoter:

Genomic Locations for WFDC10B Gene

Genomic Locations for WFDC10B Gene
20,369 bases
Minus strand

Genomic View for WFDC10B Gene

Genes around WFDC10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC10B Gene

Proteins for WFDC10B Gene

  • Protein details for WFDC10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WFDC10B
    Protein Accession:
    Secondary Accessions:
    • A6PVD7
    • Q0VAG0
    • Q0VAG1
    • Q5TGZ5
    • Q8IUB4

    Protein attributes for WFDC10B Gene

    73 amino acids
    Molecular mass:
    8325 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC10B Gene


neXtProt entry for WFDC10B Gene

Post-translational modifications for WFDC10B Gene

No Post-translational modifications

Other Protein References for WFDC10B Gene

No data available for DME Specific Peptides for WFDC10B Gene

Domains & Families for WFDC10B Gene

Gene Families for WFDC10B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WFDC10B Gene

Suggested Antigen Peptide Sequences for WFDC10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC10B: view

No data available for UniProtKB/Swiss-Prot for WFDC10B Gene

Function for WFDC10B Gene

Gene Ontology (GO) - Molecular Function for WFDC10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC10B: view
genes like me logo Genes that share phenotypes with WFDC10B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC10B Gene

Localization for WFDC10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC10B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC10B gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for WFDC10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC10B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC10B Gene

Pathways & Interactions for WFDC10B Gene

SuperPathways for WFDC10B Gene

No Data Available

Interacting Proteins for WFDC10B Gene

Selected Interacting proteins: Q8IUB3-WF10B_HUMAN for WFDC10B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC10B: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC10B Gene

Drugs & Compounds for WFDC10B Gene

No Compound Related Data Available

Transcripts for WFDC10B Gene

mRNA/cDNA for WFDC10B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC10B Gene

WAP four-disulfide core domain 10B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC10B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP2: -

Relevant External Links for WFDC10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC10B Gene

mRNA differential expression in normal tissues according to GTEx for WFDC10B Gene

This gene is overexpressed in Bladder (x13.1), Testis (x11.1), and Skin - Sun Exposed (Lower leg) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of WFDC10B Gene:


SOURCE GeneReport for Unigene cluster for WFDC10B Gene:


mRNA Expression by UniProt/SwissProt for WFDC10B Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WFDC10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC10B Gene

Orthologs for WFDC10B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for WFDC10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC10B 34
  • 98 (a)
Species where no ortholog for WFDC10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC10B Gene

Gene Tree for WFDC10B (if available)
Gene Tree for WFDC10B (if available)

Paralogs for WFDC10B Gene

Paralogs for WFDC10B Gene

(3) SIMAP similar genes for WFDC10B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC10B: view

Variants for WFDC10B Gene

Sequence variations from dbSNP and Humsavar for WFDC10B Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000127693 -- 45,685,887(-) C/A/T intron_variant
rs1000182242 -- 45,693,100(-) C/A intron_variant
rs1000324820 -- 45,694,940(-) G/A intron_variant
rs1000336479 -- 45,698,785(-) G/A intron_variant
rs1000418716 -- 45,687,983(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC10B Gene

Variant ID Type Subtype PubMed ID
nsv1055601 CNV loss 25217958
nsv474080 CNV novel sequence insertion 20440878
nsv525287 CNV loss 19592680
nsv586081 CNV loss 21841781

Variation tolerance for WFDC10B Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC10B Gene

Disorders for WFDC10B Gene

Additional Disease Information for WFDC10B

No disorders were found for WFDC10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC10B Gene

Publications for WFDC10B Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z … Hurle B (Molecular biology and evolution 2013) 3 58

Products for WFDC10B Gene

Sources for WFDC10B Gene

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