Aliases for WEE2 Gene

Aliases for WEE2 Gene

  • WEE2 Oocyte Meiosis Inhibiting Kinase 2 3 5
  • WEE1B 2 3 4
  • Wee1-Like Protein Kinase 1B 3 4
  • Wee1-Like Protein Kinase 2 3 4
  • WEE1 Homolog 2 2 3
  • Wee1B Kinase 3 4
  • EC 2.7.10.2 4 50
  • WEE1 Homolog 2 (S. Pombe) 2
  • EC 2.7.10 50
  • FLJ16107 2
  • OOMD5 3
  • WEE2 5

External Ids for WEE2 Gene

Previous GeneCards Identifiers for WEE2 Gene

  • GC07U901539
  • GC07P141055
  • GC07P141409
  • GC07P135704

Summaries for WEE2 Gene

GeneCards Summary for WEE2 Gene

WEE2 (WEE2 Oocyte Meiosis Inhibiting Kinase) is a Protein Coding gene. Diseases associated with WEE2 include Oocyte Maturation Defect 5 and Female Infertility Due To Oocyte Meiotic Arrest. Among its related pathways are Human cytomegalovirus infection and Cell cycle. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WEE1.

UniProtKB/Swiss-Prot Summary for WEE2 Gene

  • Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WEE2 Gene

Genomics for WEE2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WEE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WEE2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WEE2

Top Transcription factor binding sites by QIAGEN in the WEE2 gene promoter:
  • AML1a
  • GATA-3
  • HNF-1
  • HNF-1A
  • ITF-2
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for WEE2 Gene

Latest Assembly
chr7:141,708,353-141,731,271
(GRCh38/hg38)
Size:
22,919 bases
Orientation:
Plus strand

Previous Assembly
chr7:141,408,153-141,431,071
(GRCh37/hg19 by Entrez Gene)
Size:
22,919 bases
Orientation:
Plus strand

chr7:141,408,153-141,431,071
(GRCh37/hg19 by Ensembl)
Size:
22,919 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr7(ALT_REF_LOCI_1):80,953-103,871 (+)

Genomic View for WEE2 Gene

Genes around WEE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WEE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WEE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WEE2 Gene

Proteins for WEE2 Gene

  • Protein details for WEE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1S8-WEE2_HUMAN
    Recommended name:
    Wee1-like protein kinase 2
    Protein Accession:
    P0C1S8

    Protein attributes for WEE2 Gene

    Size:
    567 amino acids
    Molecular mass:
    62925 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WEE2 Gene

neXtProt entry for WEE2 Gene

Selected DME Specific Peptides for WEE2 Gene

P0C1S8:
  • WAEDDHM
  • LGHHPHV
  • VEEGDSRFLANE

Post-translational modifications for WEE2 Gene

  • Phosphorylated on serine residues (PubMed:29606300). Phosphorylation leads to increase its activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WEE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for WEE2 Gene

Gene Families for WEE2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WEE2 Gene

GenScript: Design optimal peptide antigens:
  • Wee1B kinase (WEE2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C1S8

UniProtKB/Swiss-Prot:

WEE2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
genes like me logo Genes that share domains with WEE2: view

Function for WEE2 Gene

Molecular function for WEE2 Gene

UniProtKB/Swiss-Prot Function:
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10027};.

Enzyme Numbers (IUBMB) for WEE2 Gene

Phenotypes From GWAS Catalog for WEE2 Gene

Gene Ontology (GO) - Molecular Function for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA,IBA 21873635
GO:0004713 protein tyrosine kinase activity IBA 21873635
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with WEE2: view
genes like me logo Genes that share phenotypes with WEE2: view

Human Phenotype Ontology for WEE2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WEE2

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for WEE2 Gene

Localization for WEE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WEE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WEE2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with WEE2: view

Pathways & Interactions for WEE2 Gene

PathCards logo

SuperPathways for WEE2 Gene

genes like me logo Genes that share pathways with WEE2: view

Pathways by source for WEE2 Gene

1 GeneTex pathway for WEE2 Gene

Gene Ontology (GO) - Biological Process for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007093 mitotic cell cycle checkpoint IBA 21873635
GO:0007143 female meiotic nuclear division IEA,ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with WEE2: view

No data available for SIGNOR curated interactions for WEE2 Gene

Drugs & Compounds for WEE2 Gene

(1) Drugs for WEE2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-1775 Investigational Pharma Wee1 kinase inhibtor,potent and ATP-competitive, Others 55

(1) ApexBio Compounds for WEE2 Gene

Compound Action Cas Number
MK-1775 Wee1 kinase inhibtor,potent and ATP-competitive 955365-80-7
genes like me logo Genes that share compounds with WEE2: view

Drug products for research

Transcripts for WEE2 Gene

mRNA/cDNA for WEE2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WEE2

Alternative Splicing Database (ASD) splice patterns (SP) for WEE2 Gene

No ASD Table

Relevant External Links for WEE2 Gene

GeneLoc Exon Structure for
WEE2

Expression for WEE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WEE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for WEE2 Gene

This gene is overexpressed in Platelet (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WEE2 Gene



Protein tissue co-expression partners for WEE2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WEE2

SOURCE GeneReport for Unigene cluster for WEE2 Gene:

Hs.657927

mRNA Expression by UniProt/SwissProt for WEE2 Gene:

P0C1S8-WEE2_HUMAN
Tissue specificity: Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659).
genes like me logo Genes that share expression patterns with WEE2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WEE2 Gene

Orthologs for WEE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WEE2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WEE2 29 30
  • 99.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WEE2 29 30
  • 83.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WEE2 29 30
  • 80.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wee2 29 16 30
  • 77.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wee2 29
  • 76.82 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WEE2 30
  • 58 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WEE2 30
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WEE2 29 30
  • 63.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WEE2 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wee2 29
  • 56.62 (n)
Zebrafish
(Danio rerio)
Actinopterygii wee2 29 30
  • 58.17 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta wee 30
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 30
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7177 30
  • 39 (a)
OneToMany
Species where no ortholog for WEE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WEE2 Gene

ENSEMBL:
Gene Tree for WEE2 (if available)
TreeFam:
Gene Tree for WEE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WEE2: view image
Alliance of Genome Resources:
Additional Orthologs for WEE2

Paralogs for WEE2 Gene

Paralogs for WEE2 Gene

(3) SIMAP similar genes for WEE2 Gene using alignment to 2 proteins:

  • WEE2_HUMAN
  • H7C5P0_HUMAN

Pseudogenes.org Pseudogenes for WEE2 Gene

genes like me logo Genes that share paralogs with WEE2: view

Variants for WEE2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WEE2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
1013566 Uncertain Significance: not provided 141,725,154(+) C/T
NM_001105558.1(WEE2):c.1350C>T (p.Asp450=)
SYNONYMOUS
977295 Pathogenic: OOCYTE MATURATION DEFECT 5 141,725,032(+) C/T
NM_001105558.1(WEE2):c.1228C>T (p.Arg410Trp)
MISSENSE
977296 Pathogenic: OOCYTE MATURATION DEFECT 5 141,724,275(+) G/A
NM_001105558.1(WEE2):c.1221G>A (p.Glu407=)
SYNONYMOUS
977297 Pathogenic: OOCYTE MATURATION DEFECT 5 141,719,084(+) C/T
NM_001105558.1(WEE2):c.598C>T (p.Arg200Ter)
NONSENSE
rs147083641 Benign: not provided 141,723,126(+) T/C
NM_001105558.1(WEE2):c.881-8T>C
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WEE2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WEE2 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for WEE2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WEE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WEE2
Leiden Open Variation Database (LOVD)
WEE2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WEE2 Gene

Disorders for WEE2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WEE2 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search WEE2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WEE2_HUMAN
  • Oocyte maturation defect 5 (OOMD5) [MIM:617996]: An autosomal recessive infertility disorder characterized by oocyte inability to exit metaphase II, resulting in fertilization failure. {ECO:0000269 PubMed:29606300}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for WEE2

genes like me logo Genes that share disorders with WEE2: view

No data available for Genatlas for WEE2 Gene

Publications for WEE2 Gene

  1. Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. (PMID: 29606300) Sang Q … Wang L (American journal of human genetics 2018) 3 4 72
  2. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. (PMID: 28792760) Zhu JY … Schönbrunn E (Journal of medicinal chemistry 2017) 2 3
  3. Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. (PMID: 23616086) Liu C … Yu B (Molecular medicine reports 2013) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. (PMID: 11029659) Nakanishi M … Sasaki M (Genes to cells : devoted to molecular & cellular mechanisms 2000) 3 4

Products for WEE2 Gene

Sources for WEE2 Gene