Aliases for WEE2 Gene
External Ids for WEE2 Gene
Previous GeneCards Identifiers for WEE2 Gene
GeneCards Summary for WEE2 Gene
WEE2 (WEE2 Oocyte Meiosis Inhibiting Kinase) is a Protein Coding gene. Diseases associated with WEE2 include Oocyte Maturation Defect 5 and Female Infertility Due To Oocyte Meiotic Arrest. Among its related pathways are Human cytomegalovirus infection and Cell cycle. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WEE1.
UniProtKB/Swiss-Prot Summary for WEE2 Gene
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).