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Aliases for WDYHV1 Gene

Aliases for WDYHV1 Gene

  • WDYHV Motif Containing 1 2 3 5
  • Protein NH2-Terminal Glutamine Deamidase 3 4
  • WDYHV Motif-Containing Protein 1 3 4
  • N-Terminal Gln Amidase 3 4
  • Nt(Q)-Amidase 3 4
  • C8orf32 3 4
  • Protein N-Terminal Glutamine Amidohydrolase 3
  • Chromosome 8 Open Reading Frame 32 2
  • EC 3.5.1.122 4
  • NTAQ1 4

External Ids for WDYHV1 Gene

Previous HGNC Symbols for WDYHV1 Gene

  • C8orf32

Previous GeneCards Identifiers for WDYHV1 Gene

  • GC08P124500
  • GC08P119754
  • GC08P124428

Summaries for WDYHV1 Gene

GeneCards Summary for WDYHV1 Gene

WDYHV1 (WDYHV Motif Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and protein-N-terminal glutamine amidohydrolase activity.

UniProtKB/Swiss-Prot for WDYHV1 Gene

  • Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

Gene Wiki entry for WDYHV1 Gene

Additional gene information for WDYHV1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDYHV1 Gene

Genomics for WDYHV1 Gene

GeneHancer (GH) Regulatory Elements for WDYHV1 Gene

Promoters and enhancers for WDYHV1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J123415 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 690.4 +0.2 216 2.3 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF143 WDYHV1 ATAD2 LOC105375737 DERL1 C8orf76 GC08P123445
GH08J123412 Enhancer 1.2 Ensembl ENCODE dbSUPER 29.1 -3.4 -3431 1.8 ELF3 FOXA2 THRB YY1 EGR1 EGR2 RXRA CEBPB ELF1 NFIL3 WDYHV1 FAM91A1 ATAD2 LOC105375737 GC08M123406
GH08J123450 Enhancer 0.8 ENCODE 39.7 +34.2 34205 1.7 HDAC1 PKNOX1 ATF1 TCF12 ZNF766 ATF7 CREM RXRA NR2F2 SP1 WDYHV1 ENSG00000278374 GC08P123445
GH08J123534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +121.8 121840 9 PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B YY1 GLIS2 ZNF213 SP3 MXD4 FBXO32 LOC105375738 ANXA13 RNF139-AS1 WDYHV1 ATAD2 GC08M123523
GH08J123758 Enhancer 1 ENCODE dbSUPER 20.3 +343.6 343644 4.7 HDAC1 PKNOX1 NFIB TCF12 GATA2 RCOR1 NCOA1 CEBPB REST ZEB2 WDYHV1 ATAD2 TATDN1 LOC105375738 FBXO32 FAM83A-AS1 FAM91A1 GC08P123742 LOC105375739
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDYHV1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDYHV1 gene promoter:
  • deltaCREB
  • CREB
  • FOXO4
  • HEN1
  • ZIC2
  • RREB-1
  • AML1a
  • TGIF
  • HFH-3
  • FOXI1

Genomic Locations for WDYHV1 Gene

Genomic Locations for WDYHV1 Gene
chr8:123,416,725-123,467,230
(GRCh38/hg38)
Size:
50,506 bases
Orientation:
Plus strand
chr8:124,428,965-124,479,470
(GRCh37/hg19)
Size:
50,506 bases
Orientation:
Plus strand

Genomic View for WDYHV1 Gene

Genes around WDYHV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDYHV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDYHV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDYHV1 Gene

Proteins for WDYHV1 Gene

  • Protein details for WDYHV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HA8-NTAQ1_HUMAN
    Recommended name:
    Protein N-terminal glutamine amidohydrolase
    Protein Accession:
    Q96HA8
    Secondary Accessions:
    • B4DE68
    • Q9NW95

    Protein attributes for WDYHV1 Gene

    Size:
    205 amino acids
    Molecular mass:
    23680 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for WDYHV1 Gene

    Alternative splice isoforms for WDYHV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDYHV1 Gene

Post-translational modifications for WDYHV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDYHV1 Gene

Domains & Families for WDYHV1 Gene

Gene Families for WDYHV1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for WDYHV1 Gene

Suggested Antigen Peptide Sequences for WDYHV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HA8

UniProtKB/Swiss-Prot:

NTAQ1_HUMAN :
  • Belongs to the NTAQ1 family.
Family:
  • Belongs to the NTAQ1 family.
genes like me logo Genes that share domains with WDYHV1: view

Function for WDYHV1 Gene

Molecular function for WDYHV1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
UniProtKB/Swiss-Prot CatalyticActivity:
N-terminal L-glutaminyl-[protein] + H(2)O = N-terminal L-glutamyl-[protein] + NH(3).

Enzyme Numbers (IUBMB) for WDYHV1 Gene

Phenotypes From GWAS Catalog for WDYHV1 Gene

Gene Ontology (GO) - Molecular Function for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity IEA --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA --
GO:0070773 protein-N-terminal glutamine amidohydrolase activity ISS --
genes like me logo Genes that share ontologies with WDYHV1: view

Phenotypes for WDYHV1 Gene

genes like me logo Genes that share phenotypes with WDYHV1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDYHV1 Gene

Localization for WDYHV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDYHV1 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDYHV1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with WDYHV1: view

Pathways & Interactions for WDYHV1 Gene

SuperPathways for WDYHV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process ISS --
genes like me logo Genes that share ontologies with WDYHV1: view

No data available for Pathways by source and SIGNOR curated interactions for WDYHV1 Gene

Drugs & Compounds for WDYHV1 Gene

No Compound Related Data Available

Transcripts for WDYHV1 Gene

Unigene Clusters for WDYHV1 Gene

WDYHV motif containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDYHV1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: -
SP3: - -
SP4:
SP5: - -

Relevant External Links for WDYHV1 Gene

GeneLoc Exon Structure for
WDYHV1
ECgene alternative splicing isoforms for
WDYHV1

Expression for WDYHV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDYHV1 Gene

Protein differential expression in normal tissues from HIPED for WDYHV1 Gene

This gene is overexpressed in Ovary (15.8), Retina (12.5), Fetal ovary (10.3), Fetal testis (7.9), Prostate (7.0), and Spleen (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDYHV1 Gene



Protein tissue co-expression partners for WDYHV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDYHV1 Gene:

WDYHV1

SOURCE GeneReport for Unigene cluster for WDYHV1 Gene:

Hs.18029

Evidence on tissue expression from TISSUES for WDYHV1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with WDYHV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDYHV1 Gene

Orthologs for WDYHV1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDYHV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDYHV1 34 33
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDYHV1 34 33
  • 91.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WDYHV1 34 33
  • 89.3 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDYHV1 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdyhv1 33
  • 84.15 (n)
mouse
(Mus musculus)
Mammalia Wdyhv1 16 34 33
  • 83.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDYHV1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDYHV1 34 33
  • 72.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDYHV1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdyhv1 33
  • 66.49 (n)
Str.12794 33
zebrafish
(Danio rerio)
Actinopterygii wdyhv1 34 33
  • 67.51 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NTAQ1_ANOGA 33
  • 55 (n)
fruit fly
(Drosophila melanogaster)
Insecta tun 34 33
  • 50.09 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R06C7.6 34 33
  • 48.3 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41760 33
  • 54.62 (n)
rice
(Oryza sativa)
Liliopsida Os05g0387900 33
  • 54.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for WDYHV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDYHV1 Gene

ENSEMBL:
Gene Tree for WDYHV1 (if available)
TreeFam:
Gene Tree for WDYHV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDYHV1: view image

Paralogs for WDYHV1 Gene

(1) SIMAP similar genes for WDYHV1 Gene using alignment to 5 proteins:

  • NTAQ1_HUMAN
  • E5RHC2_HUMAN
  • E5RIY9_HUMAN
  • E9PRB7_HUMAN
  • H0YBV4_HUMAN
genes like me logo Genes that share paralogs with WDYHV1: view

No data available for Paralogs for WDYHV1 Gene

Variants for WDYHV1 Gene

Sequence variations from dbSNP and Humsavar for WDYHV1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000016239 -- 123,417,955(+) A/T intron_variant
rs1000067192 -- 123,456,036(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000198619 -- 123,454,914(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000204153 -- 123,448,208(+) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000277034 -- 123,432,541(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDYHV1 Gene

Variant ID Type Subtype PubMed ID
esv1157152 CNV insertion 17803354
esv3618668 CNV loss 21293372
nsv831449 CNV loss 17160897

Variation tolerance for WDYHV1 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.37; 99.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDYHV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDYHV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDYHV1 Gene

Disorders for WDYHV1 Gene

Additional Disease Information for WDYHV1

No disorders were found for WDYHV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDYHV1 Gene

Publications for WDYHV1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58

Products for WDYHV1 Gene

Sources for WDYHV1 Gene

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