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Aliases for WDTC1 Gene

Aliases for WDTC1 Gene

  • WD And Tetratricopeptide Repeats 1 2 3 5
  • DDB1 And CUL4 Associated Factor 9 2 3
  • WD And Tetratricopeptide Repeats Protein 1 3
  • Adipose Homolog (Drosophila) 2
  • Adipose Homolog 3
  • KIAA1037 4
  • DCAF9 3
  • ADP 3

External Ids for WDTC1 Gene

Previous GeneCards Identifiers for WDTC1 Gene

  • GC01P027165
  • GC01P027134
  • GC01P027433
  • GC01P027561
  • GC01P025818

Summaries for WDTC1 Gene

GeneCards Summary for WDTC1 Gene

WDTC1 (WD And Tetratricopeptide Repeats 1) is a Protein Coding gene. Diseases associated with WDTC1 include Hermansky-Pudlak Syndrome 2 and Alzheimer Disease 8. Gene Ontology (GO) annotations related to this gene include histone binding and enzyme inhibitor activity. An important paralog of this gene is DCAF6.

UniProtKB/Swiss-Prot for WDTC1 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for WDTC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDTC1 Gene

Genomics for WDTC1 Gene

GeneHancer (GH) Regulatory Elements for WDTC1 Gene

Promoters and enhancers for WDTC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I027233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.6 +0.2 170 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B POLR2B E2F8 ZNF207 WDTC1 LOC105376890 LOC101928728 LOC101928324 FAM76A PIGV ENSG00000243659 TMEM222 GC01M027256 ENSG00000252098
GH01I027135 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.3 -96.9 -96913 4.1 HDAC1 HDGF PKNOX1 ATF1 KLF17 SIN3A ZBTB40 ZNF766 SCRT2 ZNF143 ZDHHC18 WDTC1 LOC105376890 SLC9A1 TMEM222 ACTG1P20 RNU6-48P GPATCH3 NUDC FGR
GH01I026958 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.9 -273.7 -273674 3.9 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ELK1 GC01P026960 KDF1 PIGV NR0B2 NUDC FAM46B GPATCH3 ENSG00000226698 SFN LOC105376890
GH01I026782 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.9 -447.4 -447370 9.2 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A PIGV ARID1A HMGN2 ACTG1P20 GPN2 LOC101928324 ENSG00000231344 GPATCH3 RPL17P9 FAM76A
GH01I027140 Enhancer 1.3 Ensembl ENCODE dbSUPER 14.7 -90.9 -90877 6.8 PKNOX1 SIN3A ZNF280A FOS ATF7 REST ZNF592 GMEB1 SMARCA4 GLIS1 WDTC1 LOC105376890 TMEM222 ACTG1P20 RNU6-48P GPATCH3 NUDC SLC9A1 LOC102723760 GC01P027051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDTC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDTC1 gene promoter:

Genomic Locations for WDTC1 Gene

Genomic Locations for WDTC1 Gene
chr1:27,234,516-27,308,633
(GRCh38/hg38)
Size:
74,118 bases
Orientation:
Plus strand
chr1:27,561,007-27,635,110
(GRCh37/hg19)

Genomic View for WDTC1 Gene

Genes around WDTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDTC1 Gene

Proteins for WDTC1 Gene

  • Protein details for WDTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5D0-WDTC1_HUMAN
    Recommended name:
    WD and tetratricopeptide repeats protein 1
    Protein Accession:
    Q8N5D0
    Secondary Accessions:
    • D3DPL5
    • Q5SSC5
    • Q9NV87
    • Q9UPW4

    Protein attributes for WDTC1 Gene

    Size:
    677 amino acids
    Molecular mass:
    75920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WDTC1 Gene

    Alternative splice isoforms for WDTC1 Gene

neXtProt entry for WDTC1 Gene

Post-translational modifications for WDTC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDTC1 Gene

No data available for DME Specific Peptides for WDTC1 Gene

Domains & Families for WDTC1 Gene

Suggested Antigen Peptide Sequences for WDTC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDTC1: view

No data available for UniProtKB/Swiss-Prot for WDTC1 Gene

Function for WDTC1 Gene

Molecular function for WDTC1 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 16964240
GO:0042393 histone binding IEA --
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with WDTC1: view
genes like me logo Genes that share phenotypes with WDTC1: view

Animal Models for WDTC1 Gene

MGI Knock Outs for WDTC1:

Animal Model Products

CRISPR Products

miRNA for WDTC1 Gene

miRTarBase miRNAs that target WDTC1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDTC1 Gene

Localization for WDTC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDTC1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4
plasma membrane 3
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
golgi apparatus 3
peroxisome 2
lysosome 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDTC1 Gene

Pathways & Interactions for WDTC1 Gene

SuperPathways for WDTC1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N5D0-WDTC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0008361 regulation of cell size IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Pathways by source and SIGNOR curated interactions for WDTC1 Gene

Drugs & Compounds for WDTC1 Gene

No Compound Related Data Available

Transcripts for WDTC1 Gene

Unigene Clusters for WDTC1 Gene

WD and tetratricopeptide repeats 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: - - - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for WDTC1 Gene

GeneLoc Exon Structure for
WDTC1
ECgene alternative splicing isoforms for
WDTC1

Expression for WDTC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDTC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDTC1 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for WDTC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.4), Retina (9.7), Testis (8.9), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDTC1 Gene



Protein tissue co-expression partners for WDTC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDTC1 Gene:

WDTC1

SOURCE GeneReport for Unigene cluster for WDTC1 Gene:

Hs.469154

Evidence on tissue expression from TISSUES for WDTC1 Gene

  • Nervous system(4.9)
  • Muscle(4)
  • Blood(3.8)
  • Heart(3.7)
  • Liver(3.4)
  • Kidney(3.1)
  • Eye(2.9)
  • Pancreas(2.8)
  • Adrenal gland(2.7)
  • Intestine(2.6)
  • Lung(2.6)
  • Thyroid gland(2.5)
  • Skin(2.4)
  • Stomach(2.4)
  • Spleen(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with WDTC1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDTC1 Gene

Orthologs for WDTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDTC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDTC1 33 34
  • 99.85 (n)
oppossum
(Monodelphis domestica)
Mammalia WDTC1 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDTC1 33 34
  • 93.85 (n)
cow
(Bos Taurus)
Mammalia WDTC1 33
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Wdtc1 33 16 34
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Wdtc1 33
  • 89.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDTC1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDTC1 33 34
  • 81.67 (n)
lizard
(Anolis carolinensis)
Reptilia WDTC1 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdtc1 33
  • 73.05 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68614 33
zebrafish
(Danio rerio)
Actinopterygii wdtc1 33 34
  • 74.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003346 33
  • 52.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta adp 33 34
  • 49.97 (n)
worm
(Caenorhabditis elegans)
Secernentea adpr-1 34
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10940 33
  • 44.69 (n)
rice
(Oryza sativa)
Liliopsida Os03g0187300 33
  • 45.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8881 34
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8135 33
Species where no ortholog for WDTC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDTC1 Gene

ENSEMBL:
Gene Tree for WDTC1 (if available)
TreeFam:
Gene Tree for WDTC1 (if available)

Paralogs for WDTC1 Gene

Paralogs for WDTC1 Gene

genes like me logo Genes that share paralogs with WDTC1: view

Variants for WDTC1 Gene

Sequence variations from dbSNP and Humsavar for WDTC1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009528 -- 27,235,438(+) CC/CCCC intron_variant
rs1000013999 -- 27,276,075(+) A/G intron_variant
rs1000023631 -- 27,304,254(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000082223 -- 27,261,504(+) T/C intron_variant
rs1000087532 -- 27,283,849(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDTC1 Gene

Variant ID Type Subtype PubMed ID
esv2665584 CNV deletion 23128226
esv3585558 CNV loss 21293372
nsv1010793 CNV gain 25217958
nsv1119670 CNV deletion 24896259
nsv1122314 CNV deletion 24896259
nsv1133827 CNV deletion 24896259
nsv526051 CNV gain 19592680

Variation tolerance for WDTC1 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDTC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDTC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDTC1 Gene

Disorders for WDTC1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for WDTC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hermansky-pudlak syndrome 2
  • albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
alzheimer disease 8
  • alzheimer disease, familial, 8
qualitative platelet defect
  • qualitative platelet deficiency nos
blood coagulation disease
  • postpartum coagulation defect
primary bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search WDTC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDTC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WDTC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDTC1 Gene

Publications for WDTC1 Gene

  1. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PMID: 19238144) Lai CQ … Ordovás JM (Obesity (Silver Spring, Md.) 2009) 2 3 44 58
  2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S … Zheng N (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Control of triglyceride storage by a WD40/TPR-domain protein. (PMID: 12717455) Häder T … Brönner G (EMBO reports 2003) 2 3 58

Products for WDTC1 Gene

Sources for WDTC1 Gene

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