Aliases for WDSUB1 Gene

Aliases for WDSUB1 Gene

  • WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1 2 3 5
  • WD Repeat, SAM And U-Box Domain-Containing Protein 1 3 4
  • WDSAM1 3 4
  • WD Repeat, SAM And U-Box Domain Containing 1 2
  • WD Repeat And SAM Domain Containing 1 2
  • UBOX6 3

External Ids for WDSUB1 Gene

Previous HGNC Symbols for WDSUB1 Gene

  • WDSAM1

Previous GeneCards Identifiers for WDSUB1 Gene

  • GC02M159918
  • GC02M159800
  • GC02M160092
  • GC02M151978

Summaries for WDSUB1 Gene

GeneCards Summary for WDSUB1 Gene

WDSUB1 (WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and ubiquitin-protein transferase activity.

Additional gene information for WDSUB1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDSUB1 Gene

Genomics for WDSUB1 Gene

GeneHancer (GH) Regulatory Elements for WDSUB1 Gene

Promoters and enhancers for WDSUB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J159285 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 794.1 +0.2 229 2.3 ZNF24 SP1 ZBTB40 FOXA1 MLX RBPJ SMARCE1 POLR2A USF2 NR2F1 WDSUB1 lnc-TANC1-6 BAZ2B PLA2R1 MARCHF7 CD302 LY75 HSALNG0019903
GH02J159225 Enhancer 1 Ensembl ENCODE dbSUPER 40.4 +59.7 59698 4.2 ZBTB40 L3MBTL2 BACH1 SMARCA4 CREM ZNF316 ZNF24 EP300 NR2C1 NFE2 WDSUB1 LOC105373716 MIR6888 TANC1
GH02J159264 Enhancer 0.9 Ensembl ENCODE 34.6 +21.5 21499 1 SMARCE1 SMARCA4 CDC5L IKZF1 DPF2 ZSCAN4 PKNOX1 ZNF24 MTA2 EHMT2 WDSUB1 BTF3L4P2 HSALNG0019903
GH02J159290 Enhancer 0.9 Ensembl ENCODE 31.8 -3.9 -3902 1.4 GATA3 SMARCE1 ZNF217 HLF NFIB CEBPG SP7 SMARCA4 DPF2 POLR2A WDSUB1 lnc-TANC1-6 piR-52680-174
GH02J159248 Enhancer 0.8 FANTOM5 ENCODE 34.9 +36.8 36798 2.1 ZNF362 MAX MNT ZNF384 IKZF1 ZBTB33 IKZF2 ZBTB48 NBN ZNF514 WDSUB1 PLA2R1 BAZ2B MARCHF7 HSALNG0019903
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDSUB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDSUB1 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • NF-YB

Genomic Locations for WDSUB1 Gene

Genomic Locations for WDSUB1 Gene
chr2:159,235,793-159,286,799
(GRCh38/hg38)
Size:
51,007 bases
Orientation:
Minus strand
chr2:160,092,304-160,143,310
(GRCh37/hg19)
Size:
51,007 bases
Orientation:
Minus strand

Genomic View for WDSUB1 Gene

Genes around WDSUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDSUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDSUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDSUB1 Gene

Proteins for WDSUB1 Gene

  • Protein details for WDSUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V3-WSDU1_HUMAN
    Recommended name:
    WD repeat, SAM and U-box domain-containing protein 1
    Protein Accession:
    Q8N9V3
    Secondary Accessions:
    • Q53TI9
    • Q8N6N8

    Protein attributes for WDSUB1 Gene

    Size:
    476 amino acids
    Molecular mass:
    52817 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDSUB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDSUB1 Gene

Post-translational modifications for WDSUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDSUB1 Gene

Domains & Families for WDSUB1 Gene

Gene Families for WDSUB1 Gene

Suggested Antigen Peptide Sequences for WDSUB1 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat, sterile alpha motif and U-box domain containing 1, isoform CRA_a (D3DPA6_HUMAN)
  • WD repeat, SAM and U-box domain-containing protein 1 (WSDU1_HUMAN)
genes like me logo Genes that share domains with WDSUB1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDSUB1 Gene

Function for WDSUB1 Gene

Phenotypes From GWAS Catalog for WDSUB1 Gene

Gene Ontology (GO) - Molecular Function for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WDSUB1: view
genes like me logo Genes that share phenotypes with WDSUB1: view

Animal Models for WDSUB1 Gene

MGI Knock Outs for WDSUB1:
  • Wdsub1 Wdsub1<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for WDSUB1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDSUB1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for WDSUB1 Gene

Localization for WDSUB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDSUB1 gene
Compartment Confidence
cytosol 2
extracellular 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDSUB1 Gene

Pathways & Interactions for WDSUB1 Gene

PathCards logo

SuperPathways for WDSUB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDSUB1: view

No data available for Pathways by source and SIGNOR curated interactions for WDSUB1 Gene

Drugs & Compounds for WDSUB1 Gene

No Compound Related Data Available

Transcripts for WDSUB1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDSUB1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDSUB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5: - -

Relevant External Links for WDSUB1 Gene

GeneLoc Exon Structure for
WDSUB1
ECgene alternative splicing isoforms for
WDSUB1

Expression for WDSUB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDSUB1 Gene

Protein differential expression in normal tissues from HIPED for WDSUB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.2), Monocytes (9.9), and Blymphocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDSUB1 Gene



Protein tissue co-expression partners for WDSUB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDSUB1 Gene:

WDSUB1

SOURCE GeneReport for Unigene cluster for WDSUB1 Gene:

Hs.20848

Evidence on tissue expression from TISSUES for WDSUB1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with WDSUB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDSUB1 Gene

Orthologs for WDSUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDSUB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDSUB1 33 32
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDSUB1 33 32
  • 90.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WDSUB1 33 32
  • 90.32 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDSUB1 33
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDSUB1 33
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdsub1 32
  • 80.53 (n)
mouse
(Mus musculus)
Mammalia Wdsub1 17 33 32
  • 80.1 (n)
chicken
(Gallus gallus)
Aves WDSUB1 33 32
  • 76.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDSUB1 33
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdsub1 32
  • 63.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13287 32
zebrafish
(Danio rerio)
Actinopterygii wdsub1 33 32
  • 59.53 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5875 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005577 32
  • 44.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta can 33
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 33
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 33
  • 9 (a)
OneToMany
Species where no ortholog for WDSUB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDSUB1 Gene

ENSEMBL:
Gene Tree for WDSUB1 (if available)
TreeFam:
Gene Tree for WDSUB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDSUB1: view image

Paralogs for WDSUB1 Gene

(5) SIMAP similar genes for WDSUB1 Gene using alignment to 3 proteins:

  • WSDU1_HUMAN
  • B8ZZF2_HUMAN
  • D3DPA6_HUMAN
genes like me logo Genes that share paralogs with WDSUB1: view

No data available for Paralogs for WDSUB1 Gene

Variants for WDSUB1 Gene

Sequence variations from dbSNP and Humsavar for WDSUB1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000004631 -- 159,285,263(-) A/G intron_variant
rs1000051223 -- 159,287,753(-) T/G upstream_transcript_variant
rs1000127099 -- 159,243,305(-) C/T intron_variant
rs1000148310 -- 159,236,044(-) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000217740 -- 159,275,076(-) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDSUB1 Gene

Variant ID Type Subtype PubMed ID
dgv2074n106 CNV deletion 24896259
dgv2286e59 CNV tandem duplication 20981092
dgv7136n54 CNV loss 21841781
dgv7137n54 CNV loss 21841781
dgv7138n54 CNV loss 21841781
dgv7139n54 CNV loss 21841781
esv1008546 CNV insertion 20482838
esv1058134 CNV insertion 17803354
esv1504441 CNV insertion 17803354
esv1748759 CNV deletion 17803354
esv2245332 CNV deletion 18987734
esv2661160 CNV deletion 23128226
esv2667062 CNV deletion 23128226
esv2675744 CNV deletion 23128226
esv2721031 CNV deletion 23290073
esv2721032 CNV deletion 23290073
esv27856 CNV gain+loss 19812545
esv3021233 CNV deletion 24192839
esv33532 CNV loss 17666407
esv3412019 CNV duplication 20981092
esv3447940 CNV insertion 20981092
esv3560429 CNV deletion 23714750
esv3560430 CNV deletion 23714750
esv3593111 CNV loss 21293372
esv3946 CNV loss 18987735
nsv1008665 CNV gain 25217958
nsv1010774 CNV gain 25217958
nsv1111198 CNV tandem duplication 24896259
nsv1136430 CNV deletion 24896259
nsv1151190 CNV deletion 26484159
nsv214147 CNV insertion 16902084
nsv508175 CNV deletion 20534489
nsv583476 CNV loss 21841781
nsv820981 CNV deletion 20802225
nsv821770 CNV loss 20364138

Variation tolerance for WDSUB1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.90; 97.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDSUB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDSUB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDSUB1 Gene

Disorders for WDSUB1 Gene

Additional Disease Information for WDSUB1

No disorders were found for WDSUB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDSUB1 Gene

Publications for WDSUB1 Gene

  1. Ancient origin of animal U-box ubiquitin ligases. (PMID: 20979629) Marín I (BMC evolutionary biology 2010) 2 3 56
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira FR … Gomes MD (The Journal of biological chemistry 2013) 3 56

Products for WDSUB1 Gene

Sources for WDSUB1 Gene