The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predi... See more...

Aliases for WDR97 Gene

Aliases for WDR97 Gene

  • WD Repeat Domain 97 2 3 5
  • KIAA1875 2 3 4
  • WD Repeat-Containing Protein 97 3 4

External Ids for WDR97 Gene

Previous HGNC Symbols for WDR97 Gene

  • KIAA1875

Summaries for WDR97 Gene

Entrez Gene Summary for WDR97 Gene

  • The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]

GeneCards Summary for WDR97 Gene

WDR97 (WD Repeat Domain 97) is a Protein Coding gene.

Additional gene information for WDR97 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR97 Gene

Genomics for WDR97 Gene

GeneHancer (GH) Regulatory Elements for WDR97 Gene

Promoters and enhancers for WDR97 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J144108 Promoter 0.7 Ensembl 750.6 +0.3 275 0.4 ZNF148 ZBTB33 RFX1 EGR1 POLR2A BMI1 SUPT5H SIN3A WDR97 SHARPIN lnc-SHARPIN-4
GH08J144107 Enhancer 0.5 ENCODE 768.6 -0.1 -73 0.2 ZNF148 ZBTB33 RFX1 EGR1 POLR2A BMI1 WDR97 SHARPIN lnc-SHARPIN-4 MAF1
GH08J144110 Enhancer 0.5 ENCODE 750.6 +0.7 667 0.2 CTCF ZNF143 SIN3A BACH1 POLR2A WDR97 SHARPIN lnc-SHARPIN-4 NONHSAG051535.2
GH08J144077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.3 -29.0 -28997 3.5 SIN3A SP1 ZBTB40 SIX5 RBPJ SMARCE1 POLR2A USF2 CTBP1 NR2F1 ENSG00000255224 MIR6847 EXOSC4 ZNF7 ZNF623 CPSF1 VPS28 EEF1D ENSG00000255050 ZNF16
GH08J144062 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 34.9 -44.2 -44224 2.3 NR2F6 SP1 RXRA NR2C1 CTCF SAP130 YY1 GABPA ZFHX2 ZNF335 EXOSC4 OPLAH lnc-SHARPIN-5 WDR97 ENSG00000255224 SPATC1 CYC1 MAF1 SHARPIN PARP10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR97 on UCSC Golden Path with GeneCards custom track

Genomic Locations for WDR97 Gene

Genomic Locations for WDR97 Gene
chr8:144,107,726-144,118,315
(GRCh38/hg38)
Size:
10,590 bases
Orientation:
Plus strand
chr8:145,162,629-145,173,218
(GRCh37/hg19)
Size:
10,590 bases
Orientation:
Plus strand

Genomic View for WDR97 Gene

Genes around WDR97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR97 Gene

Proteins for WDR97 Gene

  • Protein details for WDR97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NE52-WDR97_HUMAN
    Recommended name:
    WD repeat-containing protein 97
    Protein Accession:
    A6NE52
    Secondary Accessions:
    • Q96JF2

    Protein attributes for WDR97 Gene

    Size:
    1622 amino acids
    Molecular mass:
    180307 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47504.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR97 Gene

Post-translational modifications for WDR97 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR97 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR97 Gene

Domains & Families for WDR97 Gene

Gene Families for WDR97 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR97 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein KIAA1875 (K1875_HUMAN)
genes like me logo Genes that share domains with WDR97: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR97 Gene

Function for WDR97 Gene

Phenotypes From GWAS Catalog for WDR97 Gene

genes like me logo Genes that share phenotypes with WDR97: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR97

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR97 Gene

Localization for WDR97 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR97 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR97 Gene

Pathways & Interactions for WDR97 Gene

PathCards logo

SuperPathways for WDR97 Gene

No Data Available

Interacting Proteins for WDR97 Gene

Gene Ontology (GO) - Biological Process for WDR97 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR97 Gene

Drugs & Compounds for WDR97 Gene

No Compound Related Data Available

Transcripts for WDR97 Gene

mRNA/cDNA for WDR97 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR97

Alternative Splicing Database (ASD) splice patterns (SP) for WDR97 Gene

No ASD Table

Relevant External Links for WDR97 Gene

GeneLoc Exon Structure for
WDR97
ECgene alternative splicing isoforms for
WDR97

Expression for WDR97 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR97 Gene:

WDR97

Evidence on tissue expression from TISSUES for WDR97 Gene

  • Nervous system(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR97 Gene

Orthologs for WDR97 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR97 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1875 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 69 (a)
OneToMany
-- 33
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KIAA1875 33
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 58 (a)
OneToMany
-- 33
  • 45 (a)
OneToMany
-- 33
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KIAA1875 33
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1875 33
  • 36 (a)
OneToOne
Species where no ortholog for WDR97 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR97 Gene

ENSEMBL:
Gene Tree for WDR97 (if available)
TreeFam:
Gene Tree for WDR97 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR97: view image

Paralogs for WDR97 Gene

No data available for Paralogs for WDR97 Gene

Variants for WDR97 Gene

Sequence variations from dbSNP and Humsavar for WDR97 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs11136256 benign, not specified 144,105,743(+) T/A/C upstream_transcript_variant
rs1000007447 -- 144,112,587(+) C/G intron_variant
rs1000293818 -- 144,116,981(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000481167 -- 144,107,419(+) C/G upstream_transcript_variant
rs1000506680 -- 144,116,307(+) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR97 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
esv2759651 CNV gain 17122850
esv29971 CNV loss 17803354
esv3619121 CNV loss 21293372
esv3619122 CNV gain 21293372
nsv1025071 CNV gain 25217958
nsv1030888 CNV gain 25217958
nsv428208 CNV gain 18775914
nsv466014 CNV loss 19166990
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612914 CNV loss 21841781
nsv612915 CNV loss 21841781
nsv6448 CNV insertion 18451855
nsv824802 CNV gain 20364138
nsv824803 CNV gain 20364138
nsv950015 CNV deletion 24416366

Variation tolerance for WDR97 Gene

Gene Damage Index Score: 5.26; 70.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR97 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR97

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR97 Gene

Disorders for WDR97 Gene

Additional Disease Information for WDR97

No disorders were found for WDR97 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR97 Gene

Publications for WDR97 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 56
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 56
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56

Products for WDR97 Gene

Sources for WDR97 Gene