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Aliases for WDR92 Gene

Aliases for WDR92 Gene

  • WD Repeat Domain 92 2 3 5
  • WD Repeat-Containing Protein Monad 3 4
  • Testicular Secretory Protein Li 67 3
  • WD Repeat-Containing Protein 92 3
  • Monad 3

External Ids for WDR92 Gene

Previous GeneCards Identifiers for WDR92 Gene

  • GC02M068205
  • GC02M068350
  • GC02M068094

Summaries for WDR92 Gene

Entrez Gene Summary for WDR92 Gene

  • This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for WDR92 Gene

WDR92 (WD Repeat Domain 92) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methylated histone binding.

UniProtKB/Swiss-Prot for WDR92 Gene

  • Seems to act as a modulator of apoptosis.

Additional gene information for WDR92 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR92 Gene

Genomics for WDR92 Gene

GeneHancer (GH) Regulatory Elements for WDR92 Gene

Promoters and enhancers for WDR92 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I068156 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.4 -449 3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 YY1 WDR92 PNO1 PPP3R1 PIR60274 ENSG00000273398 GC02P067636
GH02I068248 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.5 -94.0 -94045 5.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PPP3R1 WDR92 ETAA1 PNO1 LOC102724389 ENSG00000273398 GC02P067636
GH02I068192 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 19.8 -36.3 -36281 2.2 JUN TAL1 CEBPG CHAMP1 FOSL1 TCF12 ZNF316 NCOR1 EGR1 CBFA2T2 WDR92 PPP3R1 PNO1 ENSG00000273275 LOC102724389 ENSG00000273398 GC02P067636
GH02I068120 Enhancer 1.4 FANTOM5 Ensembl ENCODE 19 +36.4 36428 1.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT FEZF1 IRF4 YY1 ZNF766 E2F8 WDR92 PNO1 CNRIP1 C1D PPIAP64 LOC105374789 GC02P067636
GH02I068190 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.8 -33.8 -33802 1.7 MEIS2 FOXA2 JUN CEBPG FOSL1 PRDM10 FOSL2 FOS ZNF362 CEBPB PPP3R1 WDR92 PNO1 ENSG00000273275 LOC102724389 ENSG00000273398 GC02P067636
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR92 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR92 gene promoter:

Genomic Locations for WDR92 Gene

Genomic Locations for WDR92 Gene
chr2:68,122,936-68,157,560
(GRCh38/hg38)
Size:
34,625 bases
Orientation:
Minus strand
chr2:68,350,068-68,384,692
(GRCh37/hg19)

Genomic View for WDR92 Gene

Genes around WDR92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR92 Gene

Proteins for WDR92 Gene

  • Protein details for WDR92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MX6-WDR92_HUMAN
    Recommended name:
    WD repeat-containing protein 92
    Protein Accession:
    Q96MX6
    Secondary Accessions:
    • Q96CR6

    Protein attributes for WDR92 Gene

    Size:
    357 amino acids
    Molecular mass:
    39740 Da
    Quaternary structure:
    • Interacts with PIH1D1.

    Three dimensional structures from OCA and Proteopedia for WDR92 Gene

    Alternative splice isoforms for WDR92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR92 Gene

Post-translational modifications for WDR92 Gene

  • Ubiquitination at isoforms=269 and isoforms=2235
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR92 Gene

No data available for DME Specific Peptides for WDR92 Gene

Domains & Families for WDR92 Gene

Gene Families for WDR92 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR92 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR92: view

No data available for UniProtKB/Swiss-Prot for WDR92 Gene

Function for WDR92 Gene

Molecular function for WDR92 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a modulator of apoptosis.

Phenotypes From GWAS Catalog for WDR92 Gene

Gene Ontology (GO) - Molecular Function for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18538670
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with WDR92: view
genes like me logo Genes that share phenotypes with WDR92: view

Animal Model Products

CRISPR Products

miRNA for WDR92 Gene

miRTarBase miRNAs that target WDR92

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR92

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR92 Gene

Localization for WDR92 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR92 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR92 Gene

Pathways & Interactions for WDR92 Gene

SuperPathways for WDR92 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with WDR92: view

No data available for Pathways by source and SIGNOR curated interactions for WDR92 Gene

Drugs & Compounds for WDR92 Gene

No Compound Related Data Available

Transcripts for WDR92 Gene

Unigene Clusters for WDR92 Gene

WD repeat domain 92:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR92

Alternative Splicing Database (ASD) splice patterns (SP) for WDR92 Gene

No ASD Table

Relevant External Links for WDR92 Gene

GeneLoc Exon Structure for
WDR92
ECgene alternative splicing isoforms for
WDR92

Expression for WDR92 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR92 Gene

Protein differential expression in normal tissues from HIPED for WDR92 Gene

This gene is overexpressed in Breast (28.7) and Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR92 Gene



Protein tissue co-expression partners for WDR92 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR92 Gene:

WDR92

SOURCE GeneReport for Unigene cluster for WDR92 Gene:

Hs.631877

mRNA Expression by UniProt/SwissProt for WDR92 Gene:

Q96MX6-WDR92_HUMAN
Tissue specificity: Widely expressed with the highest expression in testis.

Evidence on tissue expression from TISSUES for WDR92 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with WDR92: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR92 Gene

Orthologs for WDR92 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR92 33
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia WDR92 33 34
  • 92.06 (n)
PPP3R1 34
  • 5 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia WDR92 33
  • 91.97 (n)
-- 34
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wdr92 33 16
  • 88.24 (n)
Ppp3r1 34
  • 5 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wdr92 33
  • 86.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
ManyToMany
-- 34
  • 4 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 5 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WDR92 33 34
  • 79.7 (n)
PPP3R1 34
  • 5 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr92 33
  • 76.69 (n)
Str.20053 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16400 33
zebrafish
(Danio rerio)
Actinopterygii wdr92 33 34
  • 72.38 (n)
ppp3r1a 34
  • 5 (a)
ManyToMany
ppp3r1b 34
  • 5 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14353 33 34
  • 58.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006359 33
  • 56.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 67 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.876 33
Species where no ortholog for WDR92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR92 Gene

ENSEMBL:
Gene Tree for WDR92 (if available)
TreeFam:
Gene Tree for WDR92 (if available)

Paralogs for WDR92 Gene

(2) SIMAP similar genes for WDR92 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR92: view

No data available for Paralogs for WDR92 Gene

Variants for WDR92 Gene

Sequence variations from dbSNP and Humsavar for WDR92 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000073957 -- 68,129,658(-) T/C downstream_transcript_variant
rs1000326171 -- 68,140,337(-) T/C intron_variant
rs1000329472 -- 68,148,060(-) G/A intron_variant
rs1000372833 -- 68,157,296(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000377423 -- 68,133,089(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR92 Gene

Variant ID Type Subtype PubMed ID
esv2762262 CNV loss 21179565
nsv834251 CNV loss 17160897

Variation tolerance for WDR92 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR92 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR92

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR92 Gene

Disorders for WDR92 Gene

Additional Disease Information for WDR92

No disorders were found for WDR92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR92 Gene

Publications for WDR92 Gene

  1. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. (PMID: 16487927) Saeki M … Kamisaki Y (Biochemical and biophysical research communications 2006) 2 3 4 58
  2. PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis. (PMID: 21078300) Inoue M … Kamisaki Y (Biochemical and biophysical research communications 2010) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for WDR92 Gene

  • Addgene plasmids for WDR92

Sources for WDR92 Gene

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