Aliases for WDR91 Gene
External Ids for WDR91 Gene
Previous GeneCards Identifiers for WDR91 Gene
GeneCards Summary for WDR91 Gene
WDR91 (WD Repeat Domain 91) is a Protein Coding gene. Diseases associated with WDR91 include Usher Syndrome, Type I.
UniProtKB/Swiss-Prot for WDR91 Gene
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).