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Aliases for WDR89 Gene

Aliases for WDR89 Gene

  • WD Repeat Domain 89 2 3 5
  • C14orf150 3 4
  • WD Repeat-Containing Protein 89 3
  • MSTP050 3

External Ids for WDR89 Gene

Previous HGNC Symbols for WDR89 Gene

  • C14orf150

Previous GeneCards Identifiers for WDR89 Gene

  • GC14M063135
  • GC14M064063
  • GC14M044230

Summaries for WDR89 Gene

GeneCards Summary for WDR89 Gene

WDR89 (WD Repeat Domain 89) is a Protein Coding gene.

Additional gene information for WDR89 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR89 Gene

Genomics for WDR89 Gene

GeneHancer (GH) Regulatory Elements for WDR89 Gene

Promoters and enhancers for WDR89 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I063639 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 557.5 +0.1 128 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 WDR89 LOC105370532 ZBTB1 LOC102723809 GCATP1 SYNE2 RNU6-1162P
GH14I063852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -213.7 -213662 6.5 SIN3A ZNF2 FOS RUNX3 SMARCB1 ZNF592 ZNF610 WT1 SP7 CTCF SYNE2 ENSG00000258824 WDR89 ENSG00000214770 PPP2R5E GC14P064073
GH14I064538 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 11.1 -898.8 -898824 4.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A BRCA1 ZNF48 YY1 GLIS2 LOC102723809 HSPA2 ZBTB25 ZBTB1 PPP1R36 ENSG00000214770 GCATP1 WDR89 SYNE2 PLEKHG3
GH14I063648 Enhancer 1 FANTOM5 Ensembl ENCODE 10.8 -8.5 -8472 3.2 PKNOX1 ZNF687 IKZF1 EBF1 ZBTB33 IKZF2 GC14M063652 ENSG00000200693 WDR89 SYNE2 LOC105370532
GH14I064324 Enhancer 0.7 ENCODE 12.6 -683.1 -683054 1 ZNF146 JUN ZNF140 BACH1 MAFG CEBPB EP300 ZEB1 MAFF ZNF316 ZBTB25 ENSG00000214770 WDR89 ZBTB1 GC14M064323 ESR2 PIR41332
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR89 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR89 gene promoter:

Genomic Locations for WDR89 Gene

Genomic Locations for WDR89 Gene
44,885 bases
Minus strand

Genomic View for WDR89 Gene

Genes around WDR89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR89 Gene

Proteins for WDR89 Gene

  • Protein details for WDR89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 89
    Protein Accession:

    Protein attributes for WDR89 Gene

    387 amino acids
    Molecular mass:
    43215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR89 Gene

Post-translational modifications for WDR89 Gene

  • Ubiquitination at isoforms=95
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR89 Gene

No data available for DME Specific Peptides for WDR89 Gene

Domains & Families for WDR89 Gene

Gene Families for WDR89 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR89: view

No data available for UniProtKB/Swiss-Prot for WDR89 Gene

Function for WDR89 Gene

Phenotypes From GWAS Catalog for WDR89 Gene

genes like me logo Genes that share phenotypes with WDR89: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR89 Gene

Localization for WDR89 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR89 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR89 Gene

Pathways & Interactions for WDR89 Gene

SuperPathways for WDR89 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR89 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR89 Gene

Drugs & Compounds for WDR89 Gene

No Compound Related Data Available

Transcripts for WDR89 Gene

Unigene Clusters for WDR89 Gene

WD repeat domain 89:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR89 Gene

No ASD Table

Relevant External Links for WDR89 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR89 Gene

Protein differential expression in normal tissues from HIPED for WDR89 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Lung (16.8), and CD4 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR89 Gene

Protein tissue co-expression partners for WDR89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR89 Gene:


SOURCE GeneReport for Unigene cluster for WDR89 Gene:


Evidence on tissue expression from TISSUES for WDR89 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with WDR89: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR89 Gene

Orthologs for WDR89 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR89 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR89 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia WDR89 33 34
  • 89.75 (n)
(Bos Taurus)
Mammalia WDR89 33 34
  • 88.43 (n)
(Rattus norvegicus)
Mammalia Wdr89 33
  • 82.04 (n)
(Mus musculus)
Mammalia Wdr89 33 16 34
  • 81.26 (n)
(Ornithorhynchus anatinus)
Mammalia WDR89 34
  • 65 (a)
(Monodelphis domestica)
Mammalia WDR89 34
  • 62 (a)
(Gallus gallus)
Aves WDR89 33 34
  • 67.1 (n)
(Anolis carolinensis)
Reptilia WDR89 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr89 33
  • 66.4 (n)
Str.16071 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17137 33
(Danio rerio)
Actinopterygii wdr89 33
  • 53.24 (n)
WDR89 34
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12134 33 34
  • 44.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005524 33
  • 42.26 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08449g 33
  • 47.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL035C 33
  • 42.69 (n)
-- 34
  • 25 (a)
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL218C 33
  • 40 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47790 33
  • 48.27 (n)
(Oryza sativa)
Liliopsida Os12g0294100 33
  • 47.67 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC63.06 33
  • 43.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02570 33
  • 41.93 (n)
Species where no ortholog for WDR89 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR89 Gene

Gene Tree for WDR89 (if available)
Gene Tree for WDR89 (if available)

Paralogs for WDR89 Gene Pseudogenes for WDR89 Gene

genes like me logo Genes that share paralogs with WDR89: view

No data available for Paralogs for WDR89 Gene

Variants for WDR89 Gene

Sequence variations from dbSNP and Humsavar for WDR89 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000007999 -- 63,632,699(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000015639 -- 63,620,333(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000046216 -- 63,598,330(-) A/G 3_prime_UTR_variant
rs1000047457 -- 63,604,871(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000068339 -- 63,643,705(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR89 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
esv2677727 CNV deletion 23128226
esv3634726 CNV gain 21293372
esv3634734 CNV gain 21293372
esv3892555 CNV loss 25118596
nsv528691 CNV gain 19592680
nsv977475 CNV duplication 23825009

Variation tolerance for WDR89 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR89 Gene

Disorders for WDR89 Gene

Additional Disease Information for WDR89

No disorders were found for WDR89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR89 Gene

Publications for WDR89 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for WDR89 Gene

Sources for WDR89 Gene

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