Aliases for WDR88 Gene

Aliases for WDR88 Gene

  • WD Repeat Domain 88 2 3 5
  • PQQ Repeat And WD Repeat-Containing Protein 3 4
  • PQQ Repeat And WD Repeat Domain Containing 2 3
  • WD Repeat-Containing Protein 88 3 4
  • PQWD 3 4
  • WDR88 5

External Ids for WDR88 Gene

Previous HGNC Symbols for WDR88 Gene

  • PQWD

Previous GeneCards Identifiers for WDR88 Gene

  • GC19P038316
  • GC19P033622
  • GC19P030125

Summaries for WDR88 Gene

GeneCards Summary for WDR88 Gene

WDR88 (WD Repeat Domain 88) is a Protein Coding gene. An important paralog of this gene is DAW1.

Additional gene information for WDR88 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR88 Gene

Genomics for WDR88 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR88 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J033133 Enhancer 0.8 Ensembl 606.5 +1.6 1611 1 ZIC2 PATZ1 ZNF600 SCRT2 ZBTB20 ZNF639 ZNF524 CTBP1 TSHZ1 OSR2 WDR88 GPATCH1 ZNF507 CEP89 RHPN2 piR-35674-256 LRP3
GH19J033132 Promoter 0.3 EPDnew 600.7 +0.0 24 0.1 WDR88 piR-35674-256 LRP3
GH19J033175 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 26.6 +44.6 44611 3.8 ZNF221 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 REST TFE3 RFX1 LRP3 ENSG00000267054 HSALNG0125414 TRT-AGT1-3 lnc-SLC7A10-1 GPATCH1 CEP89 ZNF507 LSM14A WDR88
GH19J033160 Enhancer 1.1 Ensembl ENCODE 30.1 +28.2 28210 8.6 GATAD2A PRDM10 ZNF629 RFX1 ZNF692 PRDM1 ZIC2 PKNOX1 IKZF2 SP1 piR-48325-085 GPATCH1 CEP89 ZNF507 WDR88 FAAP24 CHST8 PDCD5 RGS9BP RF00017-2931
GH19J033794 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12 +665.0 665025 5.9 ZNF221 HNRNPL CREB1 CTCF PRDM10 ZNF629 ZNF512 ZNF692 ZNF174 TARDBP KCTD15 lnc-CHST8-1 lnc-PEPD-4 ZNF599 GPATCH1 CEP89 LSM14A ZNF302 ZNF181 GARRE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR88 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR88

Top Transcription factor binding sites by QIAGEN in the WDR88 gene promoter:
  • FOXC1
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • HSF2
  • Ik-1
  • SRF
  • SRF (504 AA)

Genomic Locations for WDR88 Gene

Genomic Locations for WDR88 Gene
chr19:33,132,090-33,175,799
(GRCh38/hg38)
Size:
43,710 bases
Orientation:
Plus strand
chr19:33,622,996-33,666,705
(GRCh37/hg19)
Size:
43,710 bases
Orientation:
Plus strand

Genomic View for WDR88 Gene

Genes around WDR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR88 Gene

Proteins for WDR88 Gene

  • Protein details for WDR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMY6-WDR88_HUMAN
    Recommended name:
    WD repeat-containing protein 88
    Protein Accession:
    Q6ZMY6
    Secondary Accessions:
    • Q8NEF8

    Protein attributes for WDR88 Gene

    Size:
    472 amino acids
    Molecular mass:
    52621 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31227.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR88 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR88 Gene

Post-translational modifications for WDR88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR88 Gene

No data available for DME Specific Peptides for WDR88 Gene

Domains & Families for WDR88 Gene

Gene Families for WDR88 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR88 Gene

GenScript: Design optimal peptide antigens:
  • PQQ repeat and WD repeat-containing protein (WDR88_HUMAN)
genes like me logo Genes that share domains with WDR88: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR88 Gene

Function for WDR88 Gene

Phenotypes From GWAS Catalog for WDR88 Gene

Gene Ontology (GO) - Molecular Function for WDR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WDR88: view
genes like me logo Genes that share phenotypes with WDR88: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR88

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR88 Gene

Localization for WDR88 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR88 gene
Compartment Confidence
cytosol 2
nucleus 1
extracellular 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR88 Gene

Pathways & Interactions for WDR88 Gene

PathCards logo

SuperPathways for WDR88 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR88 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR88 Gene

Drugs & Compounds for WDR88 Gene

No Compound Related Data Available

Transcripts for WDR88 Gene

mRNA/cDNA for WDR88 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR88

Alternative Splicing Database (ASD) splice patterns (SP) for WDR88 Gene

No ASD Table

Relevant External Links for WDR88 Gene

GeneLoc Exon Structure for
WDR88

Expression for WDR88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for WDR88 Gene

This gene is overexpressed in Testis (x20.1).

Protein differential expression in normal tissues from HIPED for WDR88 Gene

This gene is overexpressed in Skin (61.5) and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR88 Gene



Protein tissue co-expression partners for WDR88 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR88

SOURCE GeneReport for Unigene cluster for WDR88 Gene:

Hs.211046
genes like me logo Genes that share expression patterns with WDR88: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR88 Gene

Orthologs for WDR88 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR88 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR88 30 31
  • 99.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR88 30 31
  • 81.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR88 30 31
  • 79.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr88 30
  • 76.95 (n)
Mouse
(Mus musculus)
Mammalia Wdr88 30 17
  • 74.65 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR88 31
  • 55 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR88 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR88 30
  • 62.96 (n)
Lizard
(Anolis carolinensis)
Reptilia WDR88 31
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr88 30
  • 58.68 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUP1 31
  • 14 (a)
OneToOne
Species where no ortholog for WDR88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for WDR88 Gene

ENSEMBL:
Gene Tree for WDR88 (if available)
TreeFam:
Gene Tree for WDR88 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR88: view image

Paralogs for WDR88 Gene

(7) SIMAP similar genes for WDR88 Gene using alignment to 2 proteins:

  • WDR88_HUMAN
  • K7EPH1_HUMAN
genes like me logo Genes that share paralogs with WDR88: view

Variants for WDR88 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR88 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_035892 A breast cancer sample p.Asp166His
rs11881580 - p.Cys310Arg

Additional dbSNP identifiers (rs#s) for WDR88 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR88 Gene

Variant ID Type Subtype PubMed ID
esv2657217 CNV deletion 23128226
esv2677868 CNV deletion 23128226
esv2718468 CNV deletion 23290073
esv3583345 CNV loss 25503493
esv3583346 CNV loss 25503493
esv3644182 CNV loss 21293372
esv3644183 CNV loss 21293372
nsv1057752 CNV gain 25217958
nsv1062625 CNV gain 25217958
nsv472030 CNV novel sequence insertion 20440878
nsv828525 CNV loss 20364138
nsv833808 CNV loss 17160897

Variation tolerance for WDR88 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR88 Gene

Human Gene Mutation Database (HGMD)
WDR88
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR88

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR88 Gene

Disorders for WDR88 Gene

Additional Disease Information for WDR88

No disorders were found for WDR88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR88 Gene

Publications for WDR88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. Exome arrays capture polygenic rare variant contributions to schizophrenia. (PMID: 26740555) Richards AL … O'Donovan MC (Human molecular genetics 2016) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4

Products for WDR88 Gene

Sources for WDR88 Gene