Aliases for WDR87 Gene

Aliases for WDR87 Gene

  • WD Repeat Domain 87 2 3 5
  • Testis Development Protein NYD-SP11 3 4
  • WD Repeat-Containing Protein 87 3 4
  • NYD-SP11 2 3
  • WDR87 5

External Ids for WDR87 Gene

Previous GeneCards Identifiers for WDR87 Gene

  • GC19M043069
  • GC19M038376
  • GC19M034824

Summaries for WDR87 Gene

GeneCards Summary for WDR87 Gene

WDR87 (WD Repeat Domain 87) is a Protein Coding gene. Diseases associated with WDR87 include Carboxypeptidase N Deficiency. Gene Ontology (GO) annotations related to this gene include binding and nicotinate-nucleotide diphosphorylase (carboxylating) activity. An important paralog of this gene is WDR25.

Additional gene information for WDR87 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR87 Gene

Genomics for WDR87 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR87 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR87 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR87

Genomic Locations for WDR87 Gene

Genomic Locations for WDR87 Gene
chr19:37,884,577-37,906,677
(GRCh38/hg38)
Size:
22,101 bases
Orientation:
Minus strand
chr19:38,375,463-38,397,317
(GRCh37/hg19)
Size:
21,855 bases
Orientation:
Minus strand

Genomic View for WDR87 Gene

Genes around WDR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR87 Gene

Proteins for WDR87 Gene

  • Protein details for WDR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQQ6-WDR87_HUMAN
    Recommended name:
    WD repeat-containing protein 87
    Protein Accession:
    Q6ZQQ6
    Secondary Accessions:
    • Q9BWV9

    Protein attributes for WDR87 Gene

    Size:
    2873 amino acids
    Molecular mass:
    333185 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK20167.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAK20167.2; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR87 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR87 Gene

Post-translational modifications for WDR87 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR87 Gene

No data available for DME Specific Peptides for WDR87 Gene

Domains & Families for WDR87 Gene

Gene Families for WDR87 Gene

Suggested Antigen Peptide Sequences for WDR87 Gene

GenScript: Design optimal peptide antigens:
  • Testis development protein NYD-SP11 (WDR87_HUMAN)
genes like me logo Genes that share domains with WDR87: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR87 Gene

Function for WDR87 Gene

Phenotypes From GWAS Catalog for WDR87 Gene

Gene Ontology (GO) - Molecular Function for WDR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WDR87: view

Phenotypes for WDR87 Gene

genes like me logo Genes that share phenotypes with WDR87: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR87

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR87 Gene

Localization for WDR87 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR87 gene
Compartment Confidence
plasma membrane 2
nucleus 2
peroxisome 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR87 Gene

Pathways & Interactions for WDR87 Gene

PathCards logo

SuperPathways for WDR87 Gene

No Data Available

Interacting Proteins for WDR87 Gene

Gene Ontology (GO) - Biological Process for WDR87 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR87 Gene

Drugs & Compounds for WDR87 Gene

No Compound Related Data Available

Transcripts for WDR87 Gene

mRNA/cDNA for WDR87 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR87

Alternative Splicing Database (ASD) splice patterns (SP) for WDR87 Gene

No ASD Table

Relevant External Links for WDR87 Gene

GeneLoc Exon Structure for
WDR87

Expression for WDR87 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for WDR87 Gene

This gene is overexpressed in Testis (x46.6).

Protein differential expression in normal tissues from HIPED for WDR87 Gene

This gene is overexpressed in Liver (25.3), Synovial fluid (12.4), and Platelet (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR87 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR87

SOURCE GeneReport for Unigene cluster for WDR87 Gene:

Hs.664194
genes like me logo Genes that share expression patterns with WDR87: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR87 Gene

Orthologs for WDR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR87 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR87 30 31
  • 97.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR87 30 31
  • 78.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR87 30 31
  • 77.2 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia 4932431P20Rik 31
  • 48 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR87 31
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR87 31
  • 34 (a)
OneToOne
Species where no ortholog for WDR87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for WDR87 Gene

ENSEMBL:
Gene Tree for WDR87 (if available)
TreeFam:
Gene Tree for WDR87 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR87: view image

Paralogs for WDR87 Gene

Paralogs for WDR87 Gene

(1) SIMAP similar genes for WDR87 Gene using alignment to 2 proteins:

  • WDR87_HUMAN
  • E7ESW6_HUMAN

Pseudogenes.org Pseudogenes for WDR87 Gene

genes like me logo Genes that share paralogs with WDR87: view

Variants for WDR87 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR87 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
668202 Likely Benign: not provided 37,888,560(-) A/G MISSENSE_VARIANT
668526 Likely Benign: not provided 37,893,759(-) G/A SYNONYMOUS_VARIANT
677192 Benign: not provided 37,893,781(-) C/G MISSENSE_VARIANT
677193 Benign: not provided 37,891,688(-) C/T SYNONYMOUS_VARIANT
677194 Benign: not provided 37,888,806(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for WDR87 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR87 Gene

Variant ID Type Subtype PubMed ID
esv3390200 CNV insertion 20981092
esv3583378 CNV loss 25503493
nsv1064401 CNV loss 25217958
nsv833820 CNV loss 17160897

Variation tolerance for WDR87 Gene

Gene Damage Index Score: 9.02; 87.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR87 Gene

Human Gene Mutation Database (HGMD)
WDR87
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR87

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR87 Gene

Disorders for WDR87 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR87 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carboxypeptidase n deficiency
  • anaphylotoxin inactivator deficiency
- elite association - COSMIC cancer census association via MalaCards
Search WDR87 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with WDR87: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR87 Gene

Publications for WDR87 Gene

  1. Physiological and pathophysiological characteristics of ataxin-3 isoforms. (PMID: 30455355) Weishäupl D … Schmidt T (The Journal of biological chemistry 2019) 3
  2. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3
  3. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. (PMID: 27684187) Rosenbluh J … Hahn WC (Cell systems 2016) 3
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for WDR87 Gene

Sources for WDR87 Gene