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Aliases for WDR86 Gene

Aliases for WDR86 Gene

  • WD Repeat Domain 86 2 3 5

External Ids for WDR86 Gene

Previous GeneCards Identifiers for WDR86 Gene

  • GC07M150709
  • GC07M151072
  • GC07M144889

Summaries for WDR86 Gene

GeneCards Summary for WDR86 Gene

WDR86 (WD Repeat Domain 86) is a Protein Coding gene. An important paralog of this gene is BTRC.

Additional gene information for WDR86 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR86 Gene

Genomics for WDR86 Gene

GeneHancer (GH) Regulatory Elements for WDR86 Gene

Promoters and enhancers for WDR86 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I151408 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.8 +1.2 1172 3.1 ELF3 PKNOX1 ZSCAN4 KLF17 ZNF76 ZNF2 RARA ZNF335 GLIS2 ZNF213 WDR86 WDR86-AS1 ENSG00000241456
GH07I151411 Enhancer 0.7 ENCODE 550.8 -1.1 -1123 0.2 CTCF TEAD4 MAX CTBP1 POLR2A TRIM24 SMARCE1 ZEB2 REST ZNF592 WDR86 CRYGN WDR86-AS1 ENSG00000241456
GH07I151424 Enhancer 1.2 Ensembl ENCODE 13.8 -17.1 -17116 6.5 HDGF FEZF1 GLI4 ZNF2 GLIS2 FOS RUNX3 ZNF214 RXRA TSHZ1 ENSG00000241456 WDR86 CRYGN WDR86-AS1 MIR3907
GH07I151365 Enhancer 1.1 Ensembl ENCODE 12.1 +43.6 43561 3.5 HDGF ATF1 ZNF2 ZNF48 YY1 ARID2 ZNF207 ZNF143 FOS ATF7 GC07M151365 WDR86-AS1 WDR86 CRYGN ENSG00000241456 RHEB SMARCD3 ENSG00000243018 NUB1 GC07P151348
GH07I151415 Enhancer 0.8 ENCODE 15.3 -5.1 -5143 0.2 FOXA2 JUN MAX CEBPG YY1 NFYB PRDM10 TRIM24 CHD2 GATAD2A WDR86 ENSG00000241456
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR86 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR86 gene promoter:

Genomic Locations for WDR86 Gene

Genomic Locations for WDR86 Gene
chr7:151,375,909-151,410,727
(GRCh38/hg38)
Size:
34,819 bases
Orientation:
Minus strand
chr7:151,072,995-151,107,813
(GRCh37/hg19)

Genomic View for WDR86 Gene

Genes around WDR86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR86 Gene

Proteins for WDR86 Gene

  • Protein details for WDR86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TI4-WDR86_HUMAN
    Recommended name:
    WD repeat-containing protein 86
    Protein Accession:
    Q86TI4
    Secondary Accessions:
    • B4DJF1
    • C9JAJ5
    • C9JXE3
    • Q3KNT1
    • Q6ZUS8

    Protein attributes for WDR86 Gene

    Size:
    376 amino acids
    Molecular mass:
    40731 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07126.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR86 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR86 Gene

Post-translational modifications for WDR86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR86 Gene

Domains & Families for WDR86 Gene

Gene Families for WDR86 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR86: view

No data available for UniProtKB/Swiss-Prot for WDR86 Gene

Function for WDR86 Gene

genes like me logo Genes that share phenotypes with WDR86: view

Animal Model Products

miRNA for WDR86 Gene

miRTarBase miRNAs that target WDR86

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR86 Gene

Localization for WDR86 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR86 gene
Compartment Confidence
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR86 Gene

Pathways & Interactions for WDR86 Gene

SuperPathways for WDR86 Gene

No Data Available

Interacting Proteins for WDR86 Gene

Gene Ontology (GO) - Biological Process for WDR86 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR86 Gene

Drugs & Compounds for WDR86 Gene

No Compound Related Data Available

Transcripts for WDR86 Gene

Unigene Clusters for WDR86 Gene

WD repeat domain 86:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR86 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - - - - - - - -
SP3: - - -
SP4: - - -

Relevant External Links for WDR86 Gene

GeneLoc Exon Structure for
WDR86
ECgene alternative splicing isoforms for
WDR86

Expression for WDR86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR86 Gene

mRNA differential expression in normal tissues according to GTEx for WDR86 Gene

This gene is overexpressed in Thyroid (x5.3), Cervix - Endocervix (x5.1), Nerve - Tibial (x4.8), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for WDR86 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR86 Gene



Protein tissue co-expression partners for WDR86 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR86 Gene:

WDR86

SOURCE GeneReport for Unigene cluster for WDR86 Gene:

Hs.647083
genes like me logo Genes that share expression patterns with WDR86: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR86 Gene

Orthologs for WDR86 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR86 33 34
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia WDR86 33 34
  • 90.24 (n)
dog
(Canis familiaris)
Mammalia WDR86 33 34
  • 90.2 (n)
mouse
(Mus musculus)
Mammalia Wdr86 33 16 34
  • 84.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR86 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR86 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR86 33 34
  • 71.56 (n)
lizard
(Anolis carolinensis)
Reptilia WDR86 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr86 33
  • 65.67 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-154o6.3 34 34
  • 13 (a)
ManyToMany
znf106b 34
  • 7 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14322 34
  • 4 (a)
OneToMany
Species where no ortholog for WDR86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR86 Gene

ENSEMBL:
Gene Tree for WDR86 (if available)
TreeFam:
Gene Tree for WDR86 (if available)

Paralogs for WDR86 Gene

Paralogs for WDR86 Gene

(8) SIMAP similar genes for WDR86 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR86: view

Variants for WDR86 Gene

Sequence variations from dbSNP and Humsavar for WDR86 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000022998 -- 151,402,864(-) C/T intron_variant
rs1000045468 -- 151,388,192(-) T/C intron_variant
rs1000077011 -- 151,407,731(-) T/A intron_variant
rs1000171408 -- 151,392,204(-) C/A intron_variant
rs1000225913 -- 151,400,474(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR86 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
dgv3993e59 CNV duplication 20981092
esv1308328 CNV insertion 17803354
esv3542659 CNV deletion 23714750
nsv1067934 OTHER inversion 25765185
nsv1117769 CNV deletion 24896259
nsv1151906 OTHER inversion 26484159
nsv6005 CNV insertion 18451855

Variation tolerance for WDR86 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR86

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR86 Gene

Disorders for WDR86 Gene

Additional Disease Information for WDR86

No disorders were found for WDR86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR86 Gene

Publications for WDR86 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 44 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for WDR86 Gene

Sources for WDR86 Gene

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