Aliases for WDR82 Gene
External Ids for WDR82 Gene
Previous HGNC Symbols for WDR82 Gene
Previous GeneCards Identifiers for WDR82 Gene
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
GeneCards Summary for WDR82 Gene
WDR82 (WD Repeat Domain 82) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).
UniProtKB/Swiss-Prot for WDR82 Gene
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.