Aliases for WDR77 Gene
External Ids for WDR77 Gene
Previous GeneCards Identifiers for WDR77 Gene
The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for WDR77 Gene
WDR77 (WD Repeat Domain 77) is a Protein Coding gene. Diseases associated with WDR77 include Prostate Cancer. Among its related pathways are Transport of the SLBP independent Mature mRNA and Chromatin organization. Gene Ontology (GO) annotations related to this gene include nuclear receptor transcription coactivator activity. An important paralog of this gene is GEMIN5.
UniProtKB/Swiss-Prot Summary for WDR77 Gene
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).