The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmi... See more...

Aliases for WDR77 Gene

Aliases for WDR77 Gene

  • WD Repeat Domain 77 2 3 5
  • Methylosome Protein 50 2 3 4
  • MEP50 2 3 4
  • WD Repeat-Containing Protein 77 3 4
  • Androgen Receptor Cofactor P44 3 4
  • P44/Mep50 3 4
  • MEP-50 3 4
  • P44 2 3
  • Testis Tissue Sperm-Binding Protein Li 44a 3
  • Nbla10071 3
  • HKMT1069 3
  • WDR77 5
  • WD45 4

External Ids for WDR77 Gene

Previous GeneCards Identifiers for WDR77 Gene

  • GC01M111695
  • GC01M111784
  • GC01M111983
  • GC01M109853

Summaries for WDR77 Gene

Entrez Gene Summary for WDR77 Gene

  • The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for WDR77 Gene

WDR77 (WD Repeat Domain 77) is a Protein Coding gene. Diseases associated with WDR77 include Prostate Cancer. Among its related pathways are Transport of the SLBP independent Mature mRNA and Chromatin organization. Gene Ontology (GO) annotations related to this gene include nuclear receptor transcription coactivator activity. An important paralog of this gene is GEMIN5.

UniProtKB/Swiss-Prot Summary for WDR77 Gene

  • Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).

Gene Wiki entry for WDR77 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR77 Gene

Genomics for WDR77 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR77 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR77 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR77

Top Transcription factor binding sites by QIAGEN in the WDR77 gene promoter:
  • Evi-1
  • Ik-2
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pbx1a

Genomic Locations for WDR77 Gene

Genomic Locations for WDR77 Gene
chr1:111,439,890-111,449,308
(GRCh38/hg38)
Size:
9,419 bases
Orientation:
Minus strand
chr1:111,982,512-111,991,998
(GRCh37/hg19)
Size:
9,487 bases
Orientation:
Minus strand

Genomic View for WDR77 Gene

Genes around WDR77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR77 Gene

Proteins for WDR77 Gene

  • Protein details for WDR77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA1-MEP50_HUMAN
    Recommended name:
    Methylosome protein 50
    Protein Accession:
    Q9BQA1
    Secondary Accessions:
    • B3KMW6
    • B4DP38
    • Q3LID2
    • Q53FU2
    • Q6JZZ5
    • Q96GK4
    • Q9BWY3

    Protein attributes for WDR77 Gene

    Size:
    342 amino acids
    Molecular mass:
    36724 Da
    Quaternary structure:
    • Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503, PubMed:18984161). Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503). Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE (PubMed:11756452). Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/H2AC20, but not with histones H2B, H3 nor H4 (PubMed:16712789). Interacts with CTDP1 and LSM11 (PubMed:12560496, PubMed:16087681). Interacts with APEX1, AR and NKX3-1 (PubMed:19188445, PubMed:12972618). Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for WDR77 Gene

    Alternative splice isoforms for WDR77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR77 Gene

Post-translational modifications for WDR77 Gene

  • Ubiquitination at Lys3 and Lys121
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR77 Gene

No data available for DME Specific Peptides for WDR77 Gene

Domains & Families for WDR77 Gene

Gene Families for WDR77 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR77 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55120, moderately similar to Methylosome protein 50 (B4DP38_HUMAN)
  • p44/Mep50 (MEP50_HUMAN)
  • WD repeat domain 77 (Q5QNY9_HUMAN)
genes like me logo Genes that share domains with WDR77: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR77 Gene

Function for WDR77 Gene

Molecular function for WDR77 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).

Phenotypes From GWAS Catalog for WDR77 Gene

Gene Ontology (GO) - Molecular Function for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11756452
GO:0008327 methyl-CpG binding IDA 25284789
GO:0030374 nuclear receptor transcription coactivator activity IGI 12972618
genes like me logo Genes that share ontologies with WDR77: view
genes like me logo Genes that share phenotypes with WDR77: view

Animal Models for WDR77 Gene

MGI Knock Outs for WDR77:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR77

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR77 Gene

Localization for WDR77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR77 Gene

Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848). {ECO:0000269 PubMed:17437848}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR77 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IGI 12972618
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IGI 12972618
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with WDR77: view

Pathways & Interactions for WDR77 Gene

genes like me logo Genes that share pathways with WDR77: view

Pathways by source for WDR77 Gene

Gene Ontology (GO) - Biological Process for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0007315 pole plasm assembly IBA 21873635
GO:0008284 positive regulation of cell proliferation IEA,IBA 21873635
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with WDR77: view

No data available for SIGNOR curated interactions for WDR77 Gene

Drugs & Compounds for WDR77 Gene

No Compound Related Data Available

Transcripts for WDR77 Gene

mRNA/cDNA for WDR77 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR77

Alternative Splicing Database (ASD) splice patterns (SP) for WDR77 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for WDR77 Gene

GeneLoc Exon Structure for
WDR77

Expression for WDR77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR77 Gene

This gene is overexpressed in Ovary (8.7) and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR77 Gene



Protein tissue co-expression partners for WDR77 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR77

SOURCE GeneReport for Unigene cluster for WDR77 Gene:

Hs.204773

mRNA Expression by UniProt/SwissProt for WDR77 Gene:

Q9BQA1-MEP50_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.

Evidence on tissue expression from TISSUES for WDR77 Gene

  • Nervous system(4.7)
  • Skin(4.7)
  • Intestine(4.6)
  • Kidney(4.5)
  • Lung(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with WDR77: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR77 Gene

Orthologs for WDR77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR77 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR77 30 31
  • 99.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR77 30 31
  • 91.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR77 30
  • 89.86 (n)
-- 31
  • 74 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Wdr77 30
  • 88.79 (n)
Mouse
(Mus musculus)
Mammalia Wdr77 30 17 31
  • 88.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR77 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR77 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR77 30 31
  • 68.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR77 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr77 30
  • 62.88 (n)
Str.19030 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8563 30
Zebrafish
(Danio rerio)
Actinopterygii wdr77 30
  • 58.31 (n)
WDR77 31
  • 48 (a)
OneToOne
-- 30
Species where no ortholog for WDR77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WDR77 Gene

ENSEMBL:
Gene Tree for WDR77 (if available)
TreeFam:
Gene Tree for WDR77 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR77: view image

Paralogs for WDR77 Gene

Paralogs for WDR77 Gene

(1) SIMAP similar genes for WDR77 Gene using alignment to 3 proteins:

  • MEP50_HUMAN
  • B4DP38_HUMAN
  • H0Y711_HUMAN

Pseudogenes.org Pseudogenes for WDR77 Gene

genes like me logo Genes that share paralogs with WDR77: view

Variants for WDR77 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR77 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs7416672 - p.Ser48Ile

Additional dbSNP identifiers (rs#s) for WDR77 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR77 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781
nsv819848 CNV loss 19587683

Variation tolerance for WDR77 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR77

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR77 Gene

Disorders for WDR77 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR77 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search WDR77 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR77

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WDR77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR77 Gene

Publications for WDR77 Gene

  1. A novel WD repeat protein component of the methylosome binds Sm proteins. (PMID: 11756452) Friesen WJ … Dreyfuss G (The Journal of biological chemistry 2002) 2 3 4 23
  2. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H … Akiyama T (Cell reports 2014) 3 4
  3. Crystal structure of the human PRMT5:MEP50 complex. (PMID: 23071334) Antonysamy S … Emtage S (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
  4. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. (PMID: 21081503) Guderian G … Grimmler M (The Journal of biological chemistry 2011) 3 4
  5. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C … Tell G (Molecular and cellular biology 2009) 3 4

Products for WDR77 Gene

Sources for WDR77 Gene