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Aliases for WDR76 Gene

Aliases for WDR76 Gene

  • WD Repeat Domain 76 2 3 5
  • WD Repeat-Containing Protein 76 3
  • CDW14 3

External Ids for WDR76 Gene

Previous GeneCards Identifiers for WDR76 Gene

  • GC15P041907
  • GC15P044119
  • GC15P020941

Summaries for WDR76 Gene

GeneCards Summary for WDR76 Gene

WDR76 (WD Repeat Domain 76) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR76 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Additional gene information for WDR76 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR76 Gene

Genomics for WDR76 Gene

GeneHancer (GH) Regulatory Elements for WDR76 Gene

Promoters and enhancers for WDR76 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 582.4 -0.9 -886 5.7 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 GLIS1 NBN WDR76 MFAP1 SPG11 CTDSPL2 ENSG00000249839 ZSCAN29 ENSG00000259563 ADAL CATSPER2 TUBGCP4
GH15I043774 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.2 -50.4 -50440 3.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF207 ELL3 SERF2 WDR76 ADAL SPG11 STRC ENSG00000259563 CTDSPL2 MFAP1 ENSG00000262560
GH15I043122 Promoter/Enhancer 1.4 Ensembl ENCODE 25.2 -703.8 -703849 1.7 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ATF7 MCM3 SP3 RXRA TMEM62 LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23
GH15I043745 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 -80.0 -80013 2.6 HDGF ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF143 SP3 SP5 NFYC CATSPER2P1 PDIA3 STRCP1 CTDSPL2 WDR76 MFAP1 SPG11 LCMT2 ELL3 ZSCAN29
GH15I044661 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +837.7 837740 6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SPG11 B2M CTDSPL2 ENSG00000259563 WDR76 TRIM69 ENSG00000249839 CATSPER2 PATL2 GC15M044698
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR76 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR76 gene promoter:

Genomic Locations for WDR76 Gene

Genomic Locations for WDR76 Gene
41,506 bases
Plus strand

Genomic View for WDR76 Gene

Genes around WDR76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR76 Gene

Proteins for WDR76 Gene

  • Protein details for WDR76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 76
    Protein Accession:
    Secondary Accessions:
    • A0MNP5
    • Q05CI4

    Protein attributes for WDR76 Gene

    626 amino acids
    Molecular mass:
    69769 Da
    Quaternary structure:
    • Interacts with CUL4A and/or CUL4B.

neXtProt entry for WDR76 Gene

Post-translational modifications for WDR76 Gene

  • Ubiquitination at isoforms=25, isoforms=73, posLast=335335, isoforms=442, and isoforms=531
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR76 Gene

No data available for DME Specific Peptides for WDR76 Gene

Domains & Families for WDR76 Gene

Gene Families for WDR76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR76 Gene

Suggested Antigen Peptide Sequences for WDR76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DDB2/WDR76 family.
  • Belongs to the WD repeat DDB2/WDR76 family.
genes like me logo Genes that share domains with WDR76: view

Function for WDR76 Gene

Molecular function for WDR76 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Phenotypes From GWAS Catalog for WDR76 Gene

Gene Ontology (GO) - Molecular Function for WDR76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
genes like me logo Genes that share ontologies with WDR76: view
genes like me logo Genes that share phenotypes with WDR76: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR76 Gene

Localization for WDR76 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR76 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with WDR76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR76 Gene

Pathways & Interactions for WDR76 Gene

SuperPathways for WDR76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:2000001 regulation of DNA damage checkpoint IBA --
genes like me logo Genes that share ontologies with WDR76: view

No data available for Pathways by source and SIGNOR curated interactions for WDR76 Gene

Drugs & Compounds for WDR76 Gene

No Compound Related Data Available

Transcripts for WDR76 Gene

Unigene Clusters for WDR76 Gene

WD repeat domain 76:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP5: - -
SP6: -

Relevant External Links for WDR76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR76 Gene

Protein differential expression in normal tissues from HIPED for WDR76 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR76 Gene

Protein tissue co-expression partners for WDR76 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR76 Gene:


SOURCE GeneReport for Unigene cluster for WDR76 Gene:


Evidence on tissue expression from TISSUES for WDR76 Gene

  • Kidney(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with WDR76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR76 Gene

Orthologs for WDR76 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR76 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR76 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia WDR76 33 34
  • 88.41 (n)
(Bos Taurus)
Mammalia WDR76 33 34
  • 86.23 (n)
(Mus musculus)
Mammalia Wdr76 33 16 34
  • 79.91 (n)
(Rattus norvegicus)
Mammalia Wdr76 33
  • 78.01 (n)
(Monodelphis domestica)
Mammalia WDR76 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia WDR76 34
  • 61 (a)
(Gallus gallus)
Aves WDR76 33
  • 57.32 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
-- 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr76 33
  • 59.64 (n)
Str.16201 33
(Danio rerio)
Actinopterygii wdr76 33 34
  • 49.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMR1 33 36
  • 42.29 (n)
-- 34
  • 23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16533g 33
  • 42.16 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR194C 33
  • 40.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRS1 33
  • 43.35 (n)
(Oryza sativa)
Liliopsida Os08g0285200 33
  • 41.18 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11420 33
  • 41.62 (n)
Species where no ortholog for WDR76 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR76 Gene

Gene Tree for WDR76 (if available)
Gene Tree for WDR76 (if available)

Paralogs for WDR76 Gene

No data available for Paralogs for WDR76 Gene

Variants for WDR76 Gene

Sequence variations from dbSNP and Humsavar for WDR76 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000072302 -- 43,843,262(+) C/A intron_variant
rs1000077066 -- 43,866,543(+) T/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000088675 -- 43,836,718(+) G/C intron_variant
rs1000109411 -- 43,852,307(+) C/T intron_variant
rs1000230889 -- 43,849,440(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR76 Gene

Variant ID Type Subtype PubMed ID
dgv4503n54 CNV loss 21841781
dgv4504n54 CNV loss 21841781
dgv4505n54 CNV loss 21841781
dgv4506n54 CNV loss 21841781
dgv4507n54 CNV loss 21841781
dgv4508n54 CNV loss 21841781
dgv4509n54 CNV loss 21841781
esv2658695 CNV deletion 23128226
esv2664548 CNV deletion 23128226
esv2749627 CNV deletion 23290073
esv2760028 CNV gain+loss 17122850
esv27765 CNV gain+loss 19812545
esv3405692 CNV insertion 20981092
esv3552375 CNV deletion 23714750
esv3636299 CNV loss 21293372
esv3636300 CNV loss 21293372
nsv1036318 CNV gain 25217958
nsv1050263 CNV loss 25217958
nsv1134440 CNV deletion 24896259
nsv511550 CNV loss 21212237
nsv512394 CNV loss 21212237
nsv569277 CNV loss 21841781
nsv569296 CNV loss 21841781
nsv819016 CNV gain 19587683
nsv820434 CNV deletion 20802225
nsv9255 CNV gain 18304495

Variation tolerance for WDR76 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR76 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR76 Gene

Disorders for WDR76 Gene

Additional Disease Information for WDR76

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR76 Gene

Publications for WDR76 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa LA … Zhang H (Nature cell biology 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PMID: 12860291) Fleischmann C … Houlston RS (Cancer letters 2003) 2 3 58

Products for WDR76 Gene

Sources for WDR76 Gene

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