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Aliases for WDR75 Gene

Aliases for WDR75 Gene

  • WD Repeat Domain 75 2 3 5
  • U3 Small Nucleolar RNA-Associated Protein 17 Homolog 3 4
  • UTP17 3 4
  • UTP17, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP17, Small Subunit (SSU) Processome Component, Homolog 3
  • WD Repeat-Containing Protein 75 3
  • NET16 3

External Ids for WDR75 Gene

Previous GeneCards Identifiers for WDR75 Gene

  • GC02P190132
  • GC02P190014
  • GC02P190306
  • GC02P182165

Summaries for WDR75 Gene

GeneCards Summary for WDR75 Gene

WDR75 (WD Repeat Domain 75) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol.

UniProtKB/Swiss-Prot for WDR75 Gene

  • Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Additional gene information for WDR75 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR75 Gene

Genomics for WDR75 Gene

GeneHancer (GH) Regulatory Elements for WDR75 Gene

Promoters and enhancers for WDR75 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I189440 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.2 0.0 -4 2.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B WDR75 LOC101927252 ORMDL1 HNRNPCP2 ANKAR PMS1 COL5A2 LOC100420666
GH02I190179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.6 +741.2 741220 6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 E2F8 C2orf88 WDR75 PMS1 ANKAR ORMDL1 NEMP2 LOC105373794 GC02M190201
GH02I190318 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 +878.2 878239 2.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 HIBCH NEMP2 ORMDL1 WDR75 ANKAR PMS1 INPP1 GC02M190201
GH02I189782 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +342.6 342593 3.6 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ORMDL1 PMS1 ANKAR HNRNPCP2 OSGEPL1-AS1 OSGEPL1 WDR75 NEMP2 ASNSD1 ENSG00000273240
GH02I190214 Enhancer 0.9 Ensembl ENCODE 22.9 +774.6 774606 3.3 SMAD1 NFIA NFIB ZNF491 ZIC2 NFIC ZNF766 LCORL ZBTB48 IKZF1 WDR75 C2orf88 HIBCH ANKAR PMS1 OSGEPL1 NAB1 GC02M190201 LOC105373794
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR75 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR75 gene promoter:

Genomic Locations for WDR75 Gene

Genomic Locations for WDR75 Gene
chr2:189,441,433-189,475,565
(GRCh38/hg38)
Size:
34,133 bases
Orientation:
Plus strand
chr2:190,306,159-190,340,291
(GRCh37/hg19)

Genomic View for WDR75 Gene

Genes around WDR75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR75 Gene

Proteins for WDR75 Gene

  • Protein details for WDR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWA0-WDR75_HUMAN
    Recommended name:
    WD repeat-containing protein 75
    Protein Accession:
    Q8IWA0
    Secondary Accessions:
    • Q96J10
    • Q9H8U8
    • Q9H9U5
    • Q9H9V8
    • Q9UIX2

    Protein attributes for WDR75 Gene

    Size:
    830 amino acids
    Molecular mass:
    94499 Da
    Quaternary structure:
    • May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).
    SequenceCaution:
    • Sequence=BAB14503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR75 Gene

Post-translational modifications for WDR75 Gene

  • Ubiquitination at isoforms=123, posLast=226226, isoforms=281, isoforms=332, posLast=354354, isoforms=682, and posLast=701701
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR75 Gene

No data available for DME Specific Peptides for WDR75 Gene

Domains & Families for WDR75 Gene

Gene Families for WDR75 Gene

Suggested Antigen Peptide Sequences for WDR75 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR75: view

No data available for UniProtKB/Swiss-Prot for WDR75 Gene

Function for WDR75 Gene

Molecular function for WDR75 Gene

UniProtKB/Swiss-Prot Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Phenotypes From GWAS Catalog for WDR75 Gene

Gene Ontology (GO) - Molecular Function for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with WDR75: view
genes like me logo Genes that share phenotypes with WDR75: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR75 Gene

Localization for WDR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR75 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR75 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 17699751
genes like me logo Genes that share ontologies with WDR75: view

Pathways & Interactions for WDR75 Gene

genes like me logo Genes that share pathways with WDR75: view

Gene Ontology (GO) - Biological Process for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0045943 positive regulation of transcription by RNA polymerase I IMP 17699751
genes like me logo Genes that share ontologies with WDR75: view

No data available for SIGNOR curated interactions for WDR75 Gene

Drugs & Compounds for WDR75 Gene

No Compound Related Data Available

Transcripts for WDR75 Gene

Unigene Clusters for WDR75 Gene

WD repeat domain 75:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for WDR75 Gene

GeneLoc Exon Structure for
WDR75
ECgene alternative splicing isoforms for
WDR75

Expression for WDR75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR75 Gene

Protein differential expression in normal tissues from HIPED for WDR75 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (9.7), Placenta (9.4), Blymphocyte (8.1), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR75 Gene



Protein tissue co-expression partners for WDR75 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR75 Gene:

WDR75

SOURCE GeneReport for Unigene cluster for WDR75 Gene:

Hs.399984

Evidence on tissue expression from TISSUES for WDR75 Gene

  • Eye(4)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with WDR75: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR75 Gene

Orthologs for WDR75 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR75 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia WDR75 34 33
  • 90.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDR75 33 34
  • 90.27 (n)
mouse
(Mus musculus)
Mammalia Wdr75 16 34 33
  • 85.13 (n)
rat
(Rattus norvegicus)
Mammalia Wdr75 33
  • 84.94 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR75 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves WDR75 33 34
  • 66.42 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr75 33
  • 64.72 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr75 33 34
  • 58.98 (n)
siby113d7.2 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007948 33
  • 43.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12050 33 34
  • 43.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAN1 36
rice
(Oryza sativa)
Liliopsida Os12g0609800 33
  • 42.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
CSA.2356 34
  • 30 (a)
OneToMany
Species where no ortholog for WDR75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR75 Gene

ENSEMBL:
Gene Tree for WDR75 (if available)
TreeFam:
Gene Tree for WDR75 (if available)

Paralogs for WDR75 Gene

Pseudogenes.org Pseudogenes for WDR75 Gene

genes like me logo Genes that share paralogs with WDR75: view

No data available for Paralogs for WDR75 Gene

Variants for WDR75 Gene

Sequence variations from dbSNP and Humsavar for WDR75 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000100795 -- 189,441,546(+) C/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000265209 -- 189,472,693(+) G/A intron_variant
rs1000342115 -- 189,448,036(+) T/C intron_variant
rs1000472594 -- 189,459,359(+) A/C coding_sequence_variant, missense_variant
rs1000551485 -- 189,440,011(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR75 Gene

Variant ID Type Subtype PubMed ID
nsv3079 CNV insertion 18451855
nsv584062 CNV gain 21841781

Variation tolerance for WDR75 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR75 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR75

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR75 Gene

Disorders for WDR75 Gene

Additional Disease Information for WDR75

No disorders were found for WDR75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR75 Gene

Publications for WDR75 Gene

  1. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PMID: 17699751) Prieto JL … McStay B (Genes & development 2007) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for WDR75 Gene

Sources for WDR75 Gene

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