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Aliases for WDR70 Gene

Aliases for WDR70 Gene

  • WD Repeat Domain 70 2 3 5

External Ids for WDR70 Gene

Previous GeneCards Identifiers for WDR70 Gene

  • GC05P037416
  • GC05P037331

Summaries for WDR70 Gene

GeneCards Summary for WDR70 Gene

WDR70 (WD Repeat Domain 70) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding.

Additional gene information for WDR70 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR70 Gene

Genomics for WDR70 Gene

GeneHancer (GH) Regulatory Elements for WDR70 Gene

Promoters and enhancers for WDR70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I037378 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 593.7 +0.2 218 1.5 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B WDR70 C5orf42 NIPBL OFD1P17 ENSG00000270558 NUP155 KCTD9P5
GH05I037369 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 61.7 -8.3 -8348 3 DMAP1 YY1 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN NR2C1 NUP155 NIPBL WDR70 C5orf42 ENSG00000250155 GC05P037328
GH05I036873 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 41 -502.2 -502247 6.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NIPBL NIPBL-AS1 WDR70 NUP155 NADK2-AS1 ENSG00000250155 KRT18P31
GH05I037248 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 42.9 -129.9 -129902 2.1 PKNOX1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 ZNF213 ELK1 C5orf42 LOC105374727 WDR70 NIPBL NUP155 OFD1P17 GC05M037029
GH05I036688 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.6 -689.2 -689211 2.4 PKNOX1 SIN3A ZNF2 ZNF213 ZNF416 ZNF207 ZNF143 SP3 REST KAT8 WDR70 NIPBL NUP155 ENSG00000250155 SLC1A3 RANBP3L NADK2-AS1 GC05P036714 ENSG00000279400
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR70 gene promoter:

Genomic Locations for WDR70 Gene

Genomic Locations for WDR70 Gene
chr5:37,379,212-37,753,435
(GRCh38/hg38)
Size:
374,224 bases
Orientation:
Plus strand
chr5:37,379,314-37,753,537
(GRCh37/hg19)

Genomic View for WDR70 Gene

Genes around WDR70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR70 Gene

Proteins for WDR70 Gene

  • Protein details for WDR70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW82-WDR70_HUMAN
    Recommended name:
    WD repeat-containing protein 70
    Protein Accession:
    Q9NW82
    Secondary Accessions:
    • Q9H053

    Protein attributes for WDR70 Gene

    Size:
    654 amino acids
    Molecular mass:
    73201 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC21644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR70 Gene

Post-translational modifications for WDR70 Gene

Other Protein References for WDR70 Gene

No data available for DME Specific Peptides for WDR70 Gene

Domains & Families for WDR70 Gene

Gene Families for WDR70 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW82

UniProtKB/Swiss-Prot:

WDR70_HUMAN :
  • Belongs to the WD repeat GAD-1 family.
Family:
  • Belongs to the WD repeat GAD-1 family.
genes like me logo Genes that share domains with WDR70: view

Function for WDR70 Gene

Phenotypes From GWAS Catalog for WDR70 Gene

Gene Ontology (GO) - Molecular Function for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with WDR70: view
genes like me logo Genes that share phenotypes with WDR70: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR70 Gene

Localization for WDR70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR70 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR70 Gene

Pathways & Interactions for WDR70 Gene

SuperPathways for WDR70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR70 Gene

Drugs & Compounds for WDR70 Gene

No Compound Related Data Available

Transcripts for WDR70 Gene

Unigene Clusters for WDR70 Gene

WD repeat domain 70:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR70 Gene

No ASD Table

Relevant External Links for WDR70 Gene

GeneLoc Exon Structure for
WDR70
ECgene alternative splicing isoforms for
WDR70

Expression for WDR70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR70 Gene

Protein differential expression in normal tissues from HIPED for WDR70 Gene

This gene is overexpressed in Esophagus (36.9) and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR70 Gene



Protein tissue co-expression partners for WDR70 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR70 Gene:

WDR70

SOURCE GeneReport for Unigene cluster for WDR70 Gene:

Hs.213690

Evidence on tissue expression from TISSUES for WDR70 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with WDR70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR70 Gene

Orthologs for WDR70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR70 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia WDR70 34
  • 95 (a)
OneToOne
LOC489225 33
  • 93.87 (n)
cow
(Bos Taurus)
Mammalia WDR70 33 34
  • 91.72 (n)
rat
(Rattus norvegicus)
Mammalia Wdr70 33
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wdr70 33 16 34
  • 88.02 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR70 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR70 33 34
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia WDR70 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr70 33
  • 73.56 (n)
Str.7113 33
zebrafish
(Danio rerio)
Actinopterygii WDR70 (1 of 2) 34
  • 75 (a)
OneToMany
LOC101884837 33
  • 69.49 (n)
WDR70 (2 of 2) 34
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5543 33 34
  • 55.56 (n)
worm
(Caenorhabditis elegans)
Secernentea gad-1 33 34
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20330 33
  • 52.16 (n)
rice
(Oryza sativa)
Liliopsida Os10g0464100 33
  • 50.51 (n)
Os.12790 33
corn
(Zea mays)
Liliopsida Zm.12874 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11370 33
Species where no ortholog for WDR70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR70 Gene

ENSEMBL:
Gene Tree for WDR70 (if available)
TreeFam:
Gene Tree for WDR70 (if available)

Paralogs for WDR70 Gene

Pseudogenes.org Pseudogenes for WDR70 Gene

genes like me logo Genes that share paralogs with WDR70: view

No data available for Paralogs for WDR70 Gene

Variants for WDR70 Gene

Sequence variations from dbSNP and Humsavar for WDR70 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000003126 -- 37,451,735(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000003541 -- 37,480,024(+) A/G intron_variant
rs1000019951 -- 37,694,696(+) G/C intron_variant
rs1000025834 -- 37,592,388(+) G/C intron_variant
rs1000026556 -- 37,741,714(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR70 Gene

Variant ID Type Subtype PubMed ID
dgv5634n100 CNV gain 25217958
dgv9722n54 CNV loss 21841781
dgv9727n54 CNV gain 21841781
esv2591687 CNV deletion 19546169
esv2661091 CNV deletion 23128226
esv2665634 CNV deletion 23128226
esv2677567 CNV deletion 23128226
esv2730085 CNV deletion 23290073
esv2730086 CNV deletion 23290073
esv2730087 CNV deletion 23290073
esv2730088 CNV deletion 23290073
esv28527 CNV loss 19812545
esv3302655 CNV tandem duplication 20981092
esv3303363 CNV mobile element insertion 20981092
esv3306061 CNV mobile element insertion 20981092
esv3327450 CNV insertion 20981092
esv3356247 CNV duplication 20981092
esv3370577 CNV insertion 20981092
esv3436232 CNV insertion 20981092
esv3436852 CNV insertion 20981092
esv3565823 CNV deletion 23714750
esv3570076 CNV loss 25503493
esv3575837 CNV gain 25503493
esv3575838 CNV gain 25503493
esv3604728 CNV gain 21293372
esv3604736 CNV loss 21293372
esv3604737 CNV loss 21293372
esv3604738 CNV gain 21293372
esv3604739 CNV loss 21293372
esv3604740 CNV loss 21293372
esv3604741 CNV gain 21293372
esv3604743 CNV gain 21293372
esv3604744 CNV loss 21293372
esv3604746 CNV loss 21293372
esv3604748 CNV gain 21293372
esv3604749 CNV loss 21293372
esv3894176 CNV loss 25118596
nsv1015514 CNV loss 25217958
nsv1018722 CNV loss 25217958
nsv1028838 CNV gain 25217958
nsv1030223 CNV loss 25217958
nsv1030797 CNV gain 25217958
nsv1033104 CNV loss 25217958
nsv1116545 OTHER inversion 24896259
nsv1129257 CNV insertion 24896259
nsv1133357 CNV tandem duplication 24896259
nsv1140532 CNV deletion 24896259
nsv1140533 CNV deletion 24896259
nsv1143132 CNV tandem duplication 24896259
nsv1151613 CNV insertion 26484159
nsv329607 CNV deletion 16902084
nsv471012 CNV gain 18288195
nsv474927 CNV novel sequence insertion 20440878
nsv476907 CNV novel sequence insertion 20440878
nsv477893 CNV novel sequence insertion 20440878
nsv597823 CNV gain 21841781
nsv597844 CNV gain 21841781
nsv597845 CNV gain 21841781
nsv597846 CNV gain 21841781
nsv819667 CNV loss 19587683
nsv950669 CNV deletion 24416366
nsv968168 CNV duplication 23825009
nsv968302 CNV duplication 23825009
nsv968905 CNV duplication 23825009
nsv980638 CNV duplication 23825009

Variation tolerance for WDR70 Gene

Residual Variation Intolerance Score: 9.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR70 Gene

Disorders for WDR70 Gene

Additional Disease Information for WDR70

No disorders were found for WDR70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR70 Gene

Publications for WDR70 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for WDR70 Gene

Sources for WDR70 Gene

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