Aliases for WDR70 Gene

Aliases for WDR70 Gene

  • WD Repeat Domain 70 2 3 5
  • WD Repeat-Containing Protein 70 3 4
  • FLJ10233 2
  • WDR70 5

External Ids for WDR70 Gene

Previous GeneCards Identifiers for WDR70 Gene

  • GC05P037416
  • GC05P037331
  • GC05P037380
  • GC05P037381
  • GC05P037384

Summaries for WDR70 Gene

GeneCards Summary for WDR70 Gene

WDR70 (WD Repeat Domain 70) is a Protein Coding gene. Diseases associated with WDR70 include Cornelia De Lange Syndrome. Gene Ontology (GO) annotations related to this gene include enzyme binding.

Additional gene information for WDR70 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR70 Gene

Genomics for WDR70 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR70 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR70 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR70

Top Transcription factor binding sites by QIAGEN in the WDR70 gene promoter:
  • C/EBPbeta
  • E2F
  • E2F-1
  • GR
  • GR-alpha
  • MIF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • SEF-1 (1)

Genomic Locations for WDR70 Gene

Genomic Locations for WDR70 Gene
374,151 bases
Plus strand
374,224 bases
Plus strand

Genomic View for WDR70 Gene

Genes around WDR70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR70 Gene

Proteins for WDR70 Gene

  • Protein details for WDR70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 70
    Protein Accession:
    Secondary Accessions:
    • Q9H053

    Protein attributes for WDR70 Gene

    654 amino acids
    Molecular mass:
    73201 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC21644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR70 Gene

Post-translational modifications for WDR70 Gene

  • Ubiquitination at Lys296
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR70 Gene

No data available for DME Specific Peptides for WDR70 Gene

Domains & Families for WDR70 Gene

Gene Families for WDR70 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR70 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 70 (WDR70_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat GAD-1 family.
  • Belongs to the WD repeat GAD-1 family.
genes like me logo Genes that share domains with WDR70: view

Function for WDR70 Gene

Phenotypes From GWAS Catalog for WDR70 Gene

Gene Ontology (GO) - Molecular Function for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with WDR70: view
genes like me logo Genes that share phenotypes with WDR70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR70

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR70 Gene

Localization for WDR70 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR70 gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0035861 site of double-strand break IBA 21873635
genes like me logo Genes that share ontologies with WDR70: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR70 Gene

Pathways & Interactions for WDR70 Gene

PathCards logo

SuperPathways for WDR70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903775 regulation of DNA double-strand break processing IBA 21873635
GO:2001173 regulation of histone H2B conserved C-terminal lysine ubiquitination IBA 21873635
genes like me logo Genes that share ontologies with WDR70: view

No data available for Pathways by source and SIGNOR curated interactions for WDR70 Gene

Drugs & Compounds for WDR70 Gene

No Compound Related Data Available

Transcripts for WDR70 Gene

mRNA/cDNA for WDR70 Gene

8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR70

Alternative Splicing Database (ASD) splice patterns (SP) for WDR70 Gene

No ASD Table

Relevant External Links for WDR70 Gene

GeneLoc Exon Structure for

Expression for WDR70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR70 Gene

Protein differential expression in normal tissues from HIPED for WDR70 Gene

This gene is overexpressed in Esophagus (36.9) and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR70 Gene

Protein tissue co-expression partners for WDR70 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR70

SOURCE GeneReport for Unigene cluster for WDR70 Gene:


Evidence on tissue expression from TISSUES for WDR70 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with WDR70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR70 Gene

Orthologs for WDR70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR70 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR70 30 31
  • 99.54 (n)
(Canis familiaris)
Mammalia WDR70 31
  • 95 (a)
LOC489225 30
  • 93.87 (n)
(Bos Taurus)
Mammalia WDR70 30 31
  • 91.72 (n)
(Rattus norvegicus)
Mammalia Wdr70 30
  • 89.19 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 89 (a)
-- 31
  • 74 (a)
-- 31
  • 65 (a)
(Mus musculus)
Mammalia Wdr70 30 17 31
  • 88.02 (n)
(Monodelphis domestica)
Mammalia WDR70 31
  • 81 (a)
(Gallus gallus)
Aves WDR70 30 31
  • 74.03 (n)
(Anolis carolinensis)
Reptilia WDR70 31
  • 75 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr70 30
  • 73.56 (n)
Str.7113 30
(Danio rerio)
Actinopterygii WDR70 (1 of 2) 31
  • 75 (a)
LOC101884837 30
  • 69.49 (n)
WDR70 (2 of 2) 31
  • 68 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5543 30 31
  • 55.56 (n)
(Caenorhabditis elegans)
Secernentea gad-1 30 31
  • 35 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G20330 30
  • 52.16 (n)
(Oryza sativa)
Liliopsida Os10g0464100 30
  • 50.51 (n)
Os.12790 30
(Zea mays)
Liliopsida Zm.12874 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11370 30
Species where no ortholog for WDR70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR70 Gene

Gene Tree for WDR70 (if available)
Gene Tree for WDR70 (if available)
Evolutionary constrained regions (ECRs) for WDR70: view image

Paralogs for WDR70 Gene Pseudogenes for WDR70 Gene

genes like me logo Genes that share paralogs with WDR70: view

No data available for Paralogs for WDR70 Gene

Variants for WDR70 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR70 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
785120 Benign: not provided 37,701,062(+) C/T SYNONYMOUS_VARIANT
787284 Benign: not provided 37,479,867(+) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WDR70 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR70 Gene

Variant ID Type Subtype PubMed ID
dgv5634n100 CNV gain 25217958
dgv9722n54 CNV loss 21841781
dgv9727n54 CNV gain 21841781
esv2591687 CNV deletion 19546169
esv2661091 CNV deletion 23128226
esv2665634 CNV deletion 23128226
esv2677567 CNV deletion 23128226
esv2730085 CNV deletion 23290073
esv2730086 CNV deletion 23290073
esv2730087 CNV deletion 23290073
esv2730088 CNV deletion 23290073
esv28527 CNV loss 19812545
esv3302655 CNV tandem duplication 20981092
esv3303363 CNV mobile element insertion 20981092
esv3306061 CNV mobile element insertion 20981092
esv3327450 CNV insertion 20981092
esv3356247 CNV duplication 20981092
esv3370577 CNV insertion 20981092
esv3436232 CNV insertion 20981092
esv3436852 CNV insertion 20981092
esv3565823 CNV deletion 23714750
esv3570076 CNV loss 25503493
esv3575837 CNV gain 25503493
esv3575838 CNV gain 25503493
esv3604728 CNV gain 21293372
esv3604736 CNV loss 21293372
esv3604737 CNV loss 21293372
esv3604738 CNV gain 21293372
esv3604739 CNV loss 21293372
esv3604740 CNV loss 21293372
esv3604741 CNV gain 21293372
esv3604743 CNV gain 21293372
esv3604744 CNV loss 21293372
esv3604746 CNV loss 21293372
esv3604748 CNV gain 21293372
esv3604749 CNV loss 21293372
esv3894176 CNV loss 25118596
nsv1015514 CNV loss 25217958
nsv1018722 CNV loss 25217958
nsv1028838 CNV gain 25217958
nsv1030223 CNV loss 25217958
nsv1030797 CNV gain 25217958
nsv1033104 CNV loss 25217958
nsv1116545 OTHER inversion 24896259
nsv1129257 CNV insertion 24896259
nsv1133357 CNV tandem duplication 24896259
nsv1140532 CNV deletion 24896259
nsv1140533 CNV deletion 24896259
nsv1143132 CNV tandem duplication 24896259
nsv1151613 CNV insertion 26484159
nsv329607 CNV deletion 16902084
nsv471012 CNV gain 18288195
nsv474927 CNV novel sequence insertion 20440878
nsv476907 CNV novel sequence insertion 20440878
nsv477893 CNV novel sequence insertion 20440878
nsv597823 CNV gain 21841781
nsv597844 CNV gain 21841781
nsv597845 CNV gain 21841781
nsv597846 CNV gain 21841781
nsv819667 CNV loss 19587683
nsv950669 CNV deletion 24416366
nsv968168 CNV duplication 23825009
nsv968302 CNV duplication 23825009
nsv968905 CNV duplication 23825009
nsv980638 CNV duplication 23825009

Variation tolerance for WDR70 Gene

Residual Variation Intolerance Score: 9.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR70 Gene

Disorders for WDR70 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR70 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cornelia de lange syndrome
  • cdls
- elite association - COSMIC cancer census association via MalaCards
Search WDR70 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR70

genes like me logo Genes that share disorders with WDR70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR70 Gene

Publications for WDR70 Gene

  1. [Functional Analysis of DNA Damage Repair Factor WDR70 and Its Mutation in Ovarian Cancer]. (PMID: 28591950) Guo LD … Chen J (Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2016) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. (PMID: 31024071) Guard SE … Old WM (Scientific reports 2019) 3
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3
  5. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3

Products for WDR70 Gene

Sources for WDR70 Gene