WDR7 Gene (Protein Coding)

WD Repeat Domain 7

GC18P056651
GIFtS:
35
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transd... See more...

Aliases for WDR7 Gene

Aliases for WDR7 Gene

  • WD Repeat Domain 7 2 3 5
  • TRAG 2 3 4
  • TGF-Beta Resistance-Associated Protein TRAG 3 4
  • WD Repeat-Containing Protein 7 3 4
  • Rabconnectin-3 Beta 3 4
  • KIAA0541 2 4
  • TGF-Beta Resistance Associated 3
  • WDR7 5

External Ids for WDR7 Gene

Previous GeneCards Identifiers for WDR7 Gene

  • GC18P054428
  • GC18P054221
  • GC18P054103
  • GC18P052488
  • GC18P052490
  • GC18P054318
  • GC18P051029

Summaries for WDR7 Gene

Entrez Gene Summary for WDR7 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR7 Gene

WDR7 (WD Repeat Domain 7) is a Protein Coding gene. Diseases associated with WDR7 include Aleutian Mink Disease and Microphthalmia, Syndromic 10. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is TEP1.

Additional gene information for WDR7 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR7 Gene

Genomics for WDR7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for WDR7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J056650 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 483 3.6 TBP ZBTB10 FEZF1 CEBPA SIX5 NR2C1 MNT DEK IKZF1 SMAD5 TXNL1 HSALNG0121734 WDR7 lnc-FECH-3 piR-50443-186 BOD1L2
GH18J057140 Enhancer 1.2 Ensembl ENCODE 13.1 +490.3 490323 2 CEBPA HES1 BHLHE40 ZIC2 HOMEZ KDM6A THAP11 CEBPB ZNF513 ARNT WDR7 BOD1L2 ENSG00000267789 HSALNG0121750 HSALNG0121747 TXNL1
GH18J057050 Enhancer 1 Ensembl ENCODE 8.8 +399.9 399862 2 BCL11A IKZF1 HES1 REST VEZF1 MAFF TAL1 RXRA EBF1 MYNN HSALNG0121742 HSALNG0121744 HSALNG0121745 LOC105372136 ST8SIA3 WDR7 BOD1L2 TXNL1
GH18J057002 Enhancer 0.9 Ensembl ENCODE 5.8 +352.8 352758 3.4 FEZF1 FOXA2 FOSL1 PRDM6 JUND BATF ELF1 NFATC1 ZNF362 IKZF1 WDR7 WDR7-OT1 HSALNG0121739 BOD1L2 TXNL1
GH18J056986 Enhancer 0.9 Ensembl ENCODE 4.4 +336.0 335958 2.2 CEBPA HOMEZ CEBPB FOXA2 TAL1 RXRA ZBTB33 JUND FOXP1 SOX5 WDR7 HSALNG0121739 WDR7-OT1 BOD1L2 TXNL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR7

Top Transcription factor binding sites by QIAGEN in the WDR7 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • Meis-1
  • Meis-1a
  • Meis-1b
  • PPAR-gamma2

Genomic Locations for WDR7 Gene

Latest Assembly
chr18:56,651,343-57,029,811
(GRCh38/hg38)
Size:
378,469 bases
Orientation:
Plus strand

Previous Assembly
chr18:54,318,590-54,697,023
(GRCh37/hg19 by Entrez Gene)
Size:
378,434 bases
Orientation:
Plus strand

chr18:54,318,574-54,698,828
(GRCh37/hg19 by Ensembl)
Size:
380,255 bases
Orientation:
Plus strand

Genomic View for WDR7 Gene

Genes around WDR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR7 Gene

Proteins for WDR7 Gene

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  3. Assay products for research

  • Protein details for WDR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E6-WDR7_HUMAN
    Recommended name:
    WD repeat-containing protein 7
    Protein Accession:
    Q9Y4E6
    Secondary Accessions:
    • A7E2C8
    • Q86UX5
    • Q86VP2
    • Q96PS7

    Protein attributes for WDR7 Gene

    Size:
    1490 amino acids
    Molecular mass:
    163810 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25467.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR7 Gene

Protein Expression for WDR7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR7 Gene

Domains & Families for WDR7 Gene

Gene Families for WDR7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for WDR7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDR7 Gene

GenScript: Design optimal peptide antigens:
  • WDR7 protein (A2RRE0_HUMAN)
  • TGF-beta resistance-associated protein TRAG (WDR7_HUMAN)
genes like me logo Genes that share domains with WDR7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR7 Gene

Function for WDR7 Gene

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  6. Cell Lines for research

Phenotypes From GWAS Catalog for WDR7 Gene

Gene Ontology (GO) - Molecular Function for WDR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with WDR7: view
genes like me logo Genes that share phenotypes with WDR7: view

Animal Models for research

miRNA for WDR7 Gene

miRTarBase miRNAs that target WDR7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR7 Gene

Localization for WDR7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR7 gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
genes like me logo Genes that share ontologies with WDR7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR7 Gene

Pathways & Interactions for WDR7 Gene

PathCards logo

SuperPathways for WDR7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR7 Gene

Drugs & Compounds for WDR7 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for WDR7 Gene

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mRNA/cDNA for WDR7 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR7

Alternative Splicing Database (ASD) splice patterns (SP) for WDR7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for WDR7 Gene

GeneLoc Exon Structure for
WDR7

Expression for WDR7 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR7 Gene

mRNA expression in normal human tissues for WDR7 Gene
mRNA expression by GTEx for WDR7 GenemRNA expression by BioGPS for WDR7 Gene

Protein differential expression in normal tissues from HIPED for WDR7 Gene

This gene is overexpressed in Frontal cortex (34.8), Brain (9.9), and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR7 Gene



Protein tissue co-expression partners for WDR7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR7

SOURCE GeneReport for Unigene cluster for WDR7 Gene:

Hs.465213

Evidence on tissue expression from TISSUES for WDR7 Gene

  • Nervous system(4.9)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with WDR7: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR7 Gene

Orthologs for WDR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia WDR7 30 31
  • 99.22 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia WDR7 31
  • 93 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia WDR7 31
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia WDR7 30 31
  • 92.24 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia WDR7 30 31
  • 88.84 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Wdr7 30
  • 87.34 (n)
Mouse
(Mus musculus)
 Mammalia Wdr7 30 17 31
  • 87.28 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves WDR7 30 31
  • 79.69 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia WDR7 31
  • 88 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia wdr7 30
  • 76.78 (n)
Zebrafish
(Danio rerio)
 Actinopterygii CABZ01073424.1 31
  • 87 (a)
 OneToMany
WDR7 31
  • 80 (a)
 OneToMany
wdr7 30
  • 68.56 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Rbcn-3B 30 31
  • 51.25 (n)
 OneToMany
EG:86E4.3 32
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008003 30
  • 24.48 (n)
Worm
(Caenorhabditis elegans)
 Secernentea rbc-2 30 31
  • 47.13 (n)
 OneToMany
Y54F10AM.9 32
  • 39 (a)
Y54F10AM.10 32
  • 36 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 41 (a)
 OneToMany
Species where no ortholog for WDR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR7 Gene

ENSEMBL:
Gene Tree for WDR7 (if available)
TreeFam:
Gene Tree for WDR7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR7: view image

Paralogs for WDR7 Gene

Paralogs for WDR7 Gene

(1) SIMAP similar genes for WDR7 Gene using alignment to 10 proteins:

  • WDR7_HUMAN
  • A2RRE0_HUMAN
  • K7ELZ4_HUMAN
  • K7EMB8_HUMAN
  • K7EMF3_HUMAN
  • K7EPQ4_HUMAN
  • K7EPY9_HUMAN
  • K7EQ29_HUMAN
  • K7ERP9_HUMAN
  • K7ES51_HUMAN
genes like me logo Genes that share paralogs with WDR7: view

Variants for WDR7 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR7 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs150350647 Benign: not provided 56,685,981(+) G/A
NM_015285.2(WDR7):c.546G>A (p.Val182=) 		SYNONYMOUS
rs34219015 Benign: not provided 56,935,887(+) C/A
NM_015285.2(WDR7):c.3813C>A (p.Ile1271=) 		SYNONYMOUS
rs34678096 Benign: not provided 56,779,504(+) C/T
NM_015285.2(WDR7):c.3021C>T (p.Pro1007=) 		SYNONYMOUS
rs35111840 Benign: not provided 56,924,025(+) T/C
NM_015285.2(WDR7):c.3630T>C (p.Thr1210=) 		SYNONYMOUS
rs535813096 Likely Benign: not provided 56,695,002(+) T/C
NM_015285.2(WDR7):c.1161T>C (p.Asn387=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDR7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDR7 Gene

Variant ID Type Subtype PubMed ID
dgv1898e59 CNV duplication 20981092
dgv456e201 CNV deletion 23290073
esv1004514 CNV insertion 20482838
esv1419362 CNV insertion 17803354
esv1508428 CNV insertion 17803354
esv2661652 CNV deletion 23128226
esv2717142 CNV deletion 23290073
esv3302922 CNV tandem duplication 20981092
esv3304911 CNV mobile element insertion 20981092
esv3365210 CNV insertion 20981092
esv3441392 CNV insertion 20981092
esv3642616 CNV gain 21293372
esv3642621 CNV loss 21293372
nsv1055436 CNV loss 25217958
nsv1056480 CNV gain 25217958
nsv1065140 CNV loss 25217958
nsv1152042 CNV deletion 26484159
nsv2317 CNV insertion 18451855
nsv471872 CNV novel sequence insertion 20440878
nsv477541 CNV novel sequence insertion 20440878
nsv510943 OTHER complex 20534489
nsv516762 CNV loss 19592680
nsv517361 CNV gain+loss 19592680
nsv521938 CNV gain 19592680
nsv524292 CNV loss 19592680
nsv577020 CNV gain 21841781
nsv817793 CNV gain 17921354
nsv954968 CNV deletion 24416366

Variation tolerance for WDR7 Gene

Residual Variation Intolerance Score: 4.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR7 Gene

Disorders for WDR7 Gene

MalaCards: The human disease database

(6) MalaCards diseases for WDR7 Gene - From: COP

Disorder Aliases PubMed IDs
aleutian mink disease
  • aleutian disease
microphthalmia, syndromic 10
  • mcops10
ulcerative stomatitis
  • stomatitis ulcerative
optic atrophy 3, autosomal dominant
  • opa3
retinitis pigmentosa 4
  • rp4
- elite association - COSMIC cancer census association via MalaCards
Search WDR7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WDR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR7 Gene

Publications for WDR7 Gene

  1. Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. (PMID: 10828621) Sanders S … Thorgeirsson SS (Cytogenetics and cell genetics 2000) 2 3 23
  2. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (PMID: 22064162) Edwards AC … Dick DM (Psychiatric genetics 2012) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 3 41

ExternalLinks

View latest publications for WDR7 gene in Mastermind

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