Aliases for WDR64 Gene

Aliases for WDR64 Gene

  • WD Repeat Domain 64 2 3 5
  • WD Repeat-Containing Protein 64 3 4

External Ids for WDR64 Gene

Previous GeneCards Identifiers for WDR64 Gene

  • GC01P238173
  • GC01P239882
  • GC01P241815
  • GC01P212273

Summaries for WDR64 Gene

GeneCards Summary for WDR64 Gene

WDR64 (WD Repeat Domain 64) is a Protein Coding gene. An important paralog of this gene is EFCAB8.

Additional gene information for WDR64 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR64 Gene

Genomics for WDR64 Gene

GeneHancer (GH) Regulatory Elements for WDR64 Gene

Promoters and enhancers for WDR64 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J241653 Enhancer 0.6 ENCODE 500.7 +2.0 1989 0.9 MEF2A NCOR1 EHMT2 TAL1 HDAC2 TCF12 DPF2 KDM1A ESRRA ARID1B WDR64 OPN3 HSALNG0011957
GH01J241603 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -44.0 -43977 17 EP300 CTCF TCF12 NCOR1 JUND FOS ZBTB5 ZNF623 REST DNMT1 KMO CHML WDR64 PLD5 OPN3 LOC105373233 lnc-CHML-1
GH01J241834 Enhancer 0.7 Ensembl 12.1 +182.6 182577 0.5 CTCF REST MYC RAD21 SMC3 NKRF IRF1 ZNF592 BCOR ZNF335 WDR64 CHML ENSG00000229022 lnc-EXO1-4 RF00017-538
GH01J241837 Enhancer 0.8 Ensembl ENCODE 10.6 +186.1 186069 2.9 TCF12 FOS RELA EP300 BRCA1 CEBPB JUN RCOR1 MAFK STAT3 WDR64 CHML ENSG00000229022 RF00017-538 lnc-EXO1-4
GH01J241828 Enhancer 0.6 Ensembl 12.1 +177.0 177022 1.4 EP300 FOXA2 ZNF184 CEBPB ZNF335 TAL1 MITF MAFF SMARCE1 ATF3 WDR64 CHML RPL6P3 LOC105373231
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR64 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR64

Top Transcription factor binding sites by QIAGEN in the WDR64 gene promoter:
  • C/EBPalpha
  • CUTL1
  • GATA-2
  • HTF
  • Ik-2
  • LCR-F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for WDR64 Gene

Genomic Locations for WDR64 Gene
150,468 bases
Plus strand
149,856 bases
Plus strand

Genomic View for WDR64 Gene

Genes around WDR64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR64 Gene

Proteins for WDR64 Gene

  • Protein details for WDR64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 64
    Protein Accession:
    Secondary Accessions:
    • B1ANT0
    • Q7Z573
    • Q96LY9

    Protein attributes for WDR64 Gene

    1081 amino acids
    Molecular mass:
    123631 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP92796.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71525.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR64 Gene


neXtProt entry for WDR64 Gene

Post-translational modifications for WDR64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR64 Gene

Domains & Families for WDR64 Gene

Gene Families for WDR64 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR64 Gene

Suggested Antigen Peptide Sequences for WDR64 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat domain 64 (B1ANT1_HUMAN)
  • WD repeat-containing protein 64 (WDR64_HUMAN)
genes like me logo Genes that share domains with WDR64: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR64 Gene

Function for WDR64 Gene

Phenotypes From GWAS Catalog for WDR64 Gene

Phenotypes for WDR64 Gene

genes like me logo Genes that share phenotypes with WDR64: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR64 Gene

Localization for WDR64 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR64 gene
Compartment Confidence
cytosol 2
nucleus 1
mitochondrion 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR64 Gene

Pathways & Interactions for WDR64 Gene

PathCards logo

SuperPathways for WDR64 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR64 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR64 Gene

Drugs & Compounds for WDR64 Gene

No Compound Related Data Available

Transcripts for WDR64 Gene

mRNA/cDNA for WDR64 Gene

4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR64 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: - - - - - -

Relevant External Links for WDR64 Gene

GeneLoc Exon Structure for

Expression for WDR64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR64 Gene

mRNA differential expression in normal tissues according to GTEx for WDR64 Gene

This gene is overexpressed in Testis (x35.8).

Protein differential expression in normal tissues from HIPED for WDR64 Gene

This gene is overexpressed in Lymph node (24.5), Plasma (8.8), and Fetal gut (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR64 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR64

SOURCE GeneReport for Unigene cluster for WDR64 Gene:

genes like me logo Genes that share expression patterns with WDR64: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR64 Gene

Orthologs for WDR64 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR64 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR64 31 30
  • 99.2 (n)
(Bos Taurus)
Mammalia WDR64 31 30
  • 87.84 (n)
(Canis familiaris)
Mammalia WDR64 30
  • 87.33 (n)
-- 31
  • 81 (a)
-- 31
  • 79 (a)
(Mus musculus)
Mammalia Wdr64 17 31 30
  • 81.89 (n)
(Rattus norvegicus)
Mammalia Wdr64 30
  • 81.68 (n)
(Monodelphis domestica)
Mammalia WDR64 31
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia WDR64 31
  • 18 (a)
(Gallus gallus)
Aves WDR64 31 30
  • 62.66 (n)
(Anolis carolinensis)
Reptilia WDR64 31
  • 53 (a)
(Danio rerio)
Actinopterygii si:dkey-1m11.8 31
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40583 31
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
Species where no ortholog for WDR64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR64 Gene

Gene Tree for WDR64 (if available)
Gene Tree for WDR64 (if available)
Evolutionary constrained regions (ECRs) for WDR64: view image

Paralogs for WDR64 Gene

genes like me logo Genes that share paralogs with WDR64: view

Variants for WDR64 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR64 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12074374 - p.Arg952Trp
rs12095445 - p.Arg647Gln

Additional dbSNP identifiers (rs#s) for WDR64 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR64 Gene

Variant ID Type Subtype PubMed ID
esv2624301 CNV insertion 19546169
esv2661246 CNV deletion 23128226
esv2673784 CNV deletion 23128226
esv2726240 CNV deletion 23290073
esv2726252 CNV deletion 23290073
esv2762521 CNV loss 21179565
esv3307648 CNV mobile element insertion 20981092
esv3337219 CNV insertion 20981092
esv3339965 CNV insertion 20981092
esv3549554 CNV deletion 23714750
esv3589349 CNV loss 21293372
esv3589350 CNV loss 21293372
esv3589351 CNV loss 21293372
nsv1002214 CNV gain 25217958
nsv1069424 CNV deletion 25765185
nsv1130987 CNV deletion 24896259
nsv528015 CNV gain 19592680
nsv549460 CNV gain 21841781

Variation tolerance for WDR64 Gene

Gene Damage Index Score: 9.09; 87.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR64 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR64 Gene

Disorders for WDR64 Gene

Additional Disease Information for WDR64

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR64 Gene

Publications for WDR64 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PMID: 20923822) Niu N … Wang L (Genome research 2010) 3 41 54
  3. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley JL … Haines JL (Genes and immunity 2009) 3 41 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M … Iacono WG (Behavior genetics 2013) 3 54

Products for WDR64 Gene

Sources for WDR64 Gene