WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008] See more...

Aliases for WDR61 Gene

Aliases for WDR61 Gene

  • WD Repeat Domain 61 2 3 5
  • Meiotic Recombination REC14 Protein Homolog 3 4
  • WD Repeat-Containing Protein 61 3 4
  • SKI8 Homolog 3 4
  • REC14 2 3
  • Recombination Protein REC14 3
  • WDR61 5
  • SKI8 3
  • Ski8 4

External Ids for WDR61 Gene

Previous GeneCards Identifiers for WDR61 Gene

  • GC15M076363
  • GC15M078575
  • GC15M055333

Summaries for WDR61 Gene

Entrez Gene Summary for WDR61 Gene

  • WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WDR61 Gene

WDR61 (WD Repeat Domain 61) is a Protein Coding gene. Diseases associated with WDR61 include Dermatitis, Atopic, 8. Among its related pathways are Metabolism of proteins and Gene Expression. An important paralog of this gene is UTP4.

UniProtKB/Swiss-Prot Summary for WDR61 Gene

  • Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

Additional gene information for WDR61 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR61 Gene

Genomics for WDR61 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR61 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR61 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR61

Top Transcription factor binding sites by QIAGEN in the WDR61 gene promoter:
  • ARP-1
  • FOXO1
  • FOXO1a
  • GR
  • GR-alpha
  • GR-beta
  • Ik-1
  • MIF-1
  • Nkx2-5
  • p53

Genomic Locations for WDR61 Gene

Genomic Locations for WDR61 Gene
chr15:78,277,835-78,299,703
(GRCh38/hg38)
Size:
21,869 bases
Orientation:
Minus strand
chr15:78,570,177-78,592,136
(GRCh37/hg19)
Size:
21,960 bases
Orientation:
Minus strand

Genomic View for WDR61 Gene

Genes around WDR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR61 Gene

Proteins for WDR61 Gene

  • Protein details for WDR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS3-WDR61_HUMAN
    Recommended name:
    WD repeat-containing protein 61
    Protein Accession:
    Q9GZS3
    Secondary Accessions:
    • D3DW84
    • Q6IA22
    • Q7Z4X4

    Protein attributes for WDR61 Gene

    Size:
    305 amino acids
    Molecular mass:
    33581 Da
    Quaternary structure:
    • Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (PubMed:16024656, PubMed:19952111, PubMed:20178742). The PAF1 complex interacts with PHF5A. Within the PAF1 complex interacts directly with PHF5A (By similarity). Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 (PubMed:16024656).

    Three dimensional structures from OCA and Proteopedia for WDR61 Gene

neXtProt entry for WDR61 Gene

Post-translational modifications for WDR61 Gene

  • Ubiquitination at Lys45 and Lys97
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR61 Gene

Domains & Families for WDR61 Gene

Gene Families for WDR61 Gene

Suggested Antigen Peptide Sequences for WDR61 Gene

GenScript: Design optimal peptide antigens:
  • Meiotic recombination REC14 protein homolog (WDR61_HUMAN)
genes like me logo Genes that share domains with WDR61: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR61 Gene

Function for WDR61 Gene

Molecular function for WDR61 Gene

UniProtKB/Swiss-Prot Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

Phenotypes From GWAS Catalog for WDR61 Gene

Gene Ontology (GO) - Molecular Function for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16024656
genes like me logo Genes that share ontologies with WDR61: view
genes like me logo Genes that share phenotypes with WDR61: view

Animal Model Products

CRISPR Products

miRNA for WDR61 Gene

miRTarBase miRNAs that target WDR61

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR61

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR61 Gene

Localization for WDR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR61 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR61 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16024656
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA,IDA 16024656
GO:0005829 cytosol IDA,TAS --
GO:0016593 Cdc73/Paf1 complex IDA 20178742
genes like me logo Genes that share ontologies with WDR61: view

Pathways & Interactions for WDR61 Gene

genes like me logo Genes that share pathways with WDR61: view

Gene Ontology (GO) - Biological Process for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016055 Wnt signaling pathway IEA --
GO:0016567 protein ubiquitination TAS --
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA 20178742
genes like me logo Genes that share ontologies with WDR61: view

No data available for SIGNOR curated interactions for WDR61 Gene

Drugs & Compounds for WDR61 Gene

No Compound Related Data Available

Transcripts for WDR61 Gene

mRNA/cDNA for WDR61 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR61

Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - -
SP9: - -
SP10: - -

Relevant External Links for WDR61 Gene

GeneLoc Exon Structure for
WDR61

Expression for WDR61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR61 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR61 Gene



Protein tissue co-expression partners for WDR61 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR61

SOURCE GeneReport for Unigene cluster for WDR61 Gene:

Hs.513055

Evidence on tissue expression from TISSUES for WDR61 Gene

  • Liver(4.4)
  • Nervous system(3.5)
  • Skin(2.5)
  • Thyroid gland(2.4)
  • Kidney(2.2)
  • Stomach(2.1)
  • Intestine(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with WDR61: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR61 Gene

Orthologs for WDR61 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR61 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR61 30 31
  • 99.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR61 30 31
  • 95.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR61 31
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Wdr61 30 17 31
  • 92.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR61 30 31
  • 92.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr61 30
  • 90.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia WDR61 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR61 30 31
  • 82.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR61 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr61 30
  • 77.7 (n)
MGC75826 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.23922 30
Zebrafish
(Danio rerio)
Actinopterygii wdr61 30 31
  • 76.61 (n)
OneToOne
zgc77675 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.610 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG3909 30 31
  • 58.56 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007626 30
  • 58.44 (n)
Worm
(Caenorhabditis elegans)
Secernentea F02E9.10 31
  • 13 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 31
  • 17 (a)
OneToMany
SKI8 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons VIP3 30
  • 51.33 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0660300 30
  • 49.04 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03517 30
  • 47.84 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rec14 30
  • 46.06 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.6680 30
Species where no ortholog for WDR61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR61 Gene

ENSEMBL:
Gene Tree for WDR61 (if available)
TreeFam:
Gene Tree for WDR61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR61: view image

Paralogs for WDR61 Gene

Paralogs for WDR61 Gene

(19) SIMAP similar genes for WDR61 Gene using alignment to 7 proteins:

  • WDR61_HUMAN
  • H0YL19_HUMAN
  • H0YLA1_HUMAN
  • H0YM76_HUMAN
  • H0YMF9_HUMAN
  • H0YN81_HUMAN
  • H3BQA8_HUMAN
genes like me logo Genes that share paralogs with WDR61: view

Variants for WDR61 Gene

Additional dbSNP identifiers (rs#s) for WDR61 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR61 Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259

Variation tolerance for WDR61 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR61

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR61 Gene

Disorders for WDR61 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR61 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dermatitis, atopic, 8
  • atod8
- elite association - COSMIC cancer census association via MalaCards
Search WDR61 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR61

genes like me logo Genes that share disorders with WDR61: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR61 Gene

Publications for WDR61 Gene

  1. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. (PMID: 20178742) Kim J … Roeder RG (Cell 2010) 3 4
  2. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PMID: 16024656) Zhu B … Reinberg D (Genes & development 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3

Products for WDR61 Gene

  • Signalway Proteins for WDR61

Sources for WDR61 Gene