This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative s... See more...

Aliases for WDR6 Gene

Aliases for WDR6 Gene

  • WD Repeat Domain 6 2 3 5
  • WD Repeat-Containing Protein 6 3 4

External Ids for WDR6 Gene

Previous GeneCards Identifiers for WDR6 Gene

  • GC15U990073
  • GC03P048192
  • GC03P048899
  • GC03P049003
  • GC03P049019
  • GC03P049044

Summaries for WDR6 Gene

Entrez Gene Summary for WDR6 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for WDR6 Gene

WDR6 (WD Repeat Domain 6) is a Protein Coding gene. Diseases associated with WDR6 include Tumoral Calcinosis, Normophosphatemic, Familial and Mitochondrial Complex I Deficiency, Nuclear Type 1. Gene Ontology (GO) annotations related to this gene include insulin receptor substrate binding.

UniProtKB/Swiss-Prot Summary for WDR6 Gene

  • Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for WDR6 Gene

Additional gene information for WDR6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR6 Gene

Genomics for WDR6 Gene

GeneHancer (GH) Regulatory Elements for WDR6 Gene

Promoters and enhancers for WDR6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR6

Top Transcription factor binding sites by QIAGEN in the WDR6 gene promoter:
  • AREB6
  • ARP-1
  • C/EBPbeta
  • CUTL1
  • Lmo2
  • Olf-1
  • Pax-6
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)

Genomic Locations for WDR6 Gene

Genomic Locations for WDR6 Gene
chr3:49,007,062-49,015,953
(GRCh38/hg38)
Size:
8,892 bases
Orientation:
Plus strand
chr3:49,044,495-49,053,386
(GRCh37/hg19)
Size:
8,892 bases
Orientation:
Plus strand

Genomic View for WDR6 Gene

Genes around WDR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR6 Gene

Proteins for WDR6 Gene

  • Protein details for WDR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNW5-WDR6_HUMAN
    Recommended name:
    WD repeat-containing protein 6
    Protein Accession:
    Q9NNW5
    Secondary Accessions:
    • B4DHK2
    • Q3MIT1
    • Q9UF63

    Protein attributes for WDR6 Gene

    Size:
    1121 amino acids
    Molecular mass:
    121725 Da
    Quaternary structure:
    • Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.
    SequenceCaution:
    • Sequence=BAG58164.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for WDR6 Gene

Post-translational modifications for WDR6 Gene

  • Ubiquitination at Lys237, Lys343, Lys418, Lys437, Lys490, Lys526, Lys708, Lys855, Lys910, and Lys915
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR6 Gene

Domains & Families for WDR6 Gene

Gene Families for WDR6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR6 Gene

GenScript: Design optimal peptide antigens:
  • WDR6 protein (Q6AZD6_HUMAN)
  • WDR6 protein (Q6PKC6_HUMAN)
  • cDNA FLJ10218 fis, clone HEMBA1006936 (Q9NW86_HUMAN)
  • WD repeat-containing protein 6 (WDR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NNW5

UniProtKB/Swiss-Prot:

WDR6_HUMAN :
  • Belongs to the WD repeat WDR6 family.
Family:
  • Belongs to the WD repeat WDR6 family.
genes like me logo Genes that share domains with WDR6: view

Function for WDR6 Gene

Molecular function for WDR6 Gene

UniProtKB/Swiss-Prot Function:
Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Phenotypes From GWAS Catalog for WDR6 Gene

Gene Ontology (GO) - Molecular Function for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI,IEA 17216128
GO:0043560 insulin receptor substrate binding IEA --
genes like me logo Genes that share ontologies with WDR6: view
genes like me logo Genes that share phenotypes with WDR6: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR6 Gene

Localization for WDR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR6 Gene

Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR6 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 17216128
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with WDR6: view

Pathways & Interactions for WDR6 Gene

PathCards logo

SuperPathways for WDR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 17216128
GO:0008285 negative regulation of cell proliferation IDA 17216128
GO:0010507 negative regulation of autophagy IMP 22354037
genes like me logo Genes that share ontologies with WDR6: view

No data available for Pathways by source and SIGNOR curated interactions for WDR6 Gene

Drugs & Compounds for WDR6 Gene

No Compound Related Data Available

Transcripts for WDR6 Gene

mRNA/cDNA for WDR6 Gene

3 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8: - - -

Relevant External Links for WDR6 Gene

GeneLoc Exon Structure for
WDR6

Expression for WDR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR6 Gene

This gene is overexpressed in Plasma (33.5), Lung (6.6), Skin (6.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR6

SOURCE GeneReport for Unigene cluster for WDR6 Gene:

Hs.654815

mRNA Expression by UniProt/SwissProt for WDR6 Gene:

Q9NNW5-WDR6_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR6 Gene

  • Nervous system(5)
  • Heart(4.3)
  • Lung(3.1)
  • Intestine(2.4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with WDR6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR6 Gene

Orthologs for WDR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR6 31 30
  • 98.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDR6 31 30
  • 89.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WDR6 31 30
  • 86.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr6 30
  • 85.34 (n)
mouse
(Mus musculus)
Mammalia Wdr6 17 31 30
  • 84.15 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR6 31
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR6 31
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR6 31 30
  • 56.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR6 31
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr6 30
  • 52.5 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr6 31 30
  • 48.98 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33172 31 30
  • 41.92 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004545 30
  • 41.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL056C 30
  • 42.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT10 31 30
  • 38.67 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18899g 30
  • 37.29 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07492 30
  • 41.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1306.02 30
  • 38.76 (n)
Species where no ortholog for WDR6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR6 Gene

ENSEMBL:
Gene Tree for WDR6 (if available)
TreeFam:
Gene Tree for WDR6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR6: view image

Paralogs for WDR6 Gene

(36) SIMAP similar genes for WDR6 Gene using alignment to 13 proteins:

  • WDR6_HUMAN
  • C9JFP6_HUMAN
  • C9K020_HUMAN
  • E5RFX3_HUMAN
  • E9PBK6_HUMAN
  • E9PDU5_HUMAN
  • F8WE36_HUMAN
  • Q6AZD6_HUMAN
  • Q6PKC6_HUMAN
  • V9GYU1_HUMAN
  • V9GYZ2_HUMAN
  • V9GZ48_HUMAN
  • V9GZ65_HUMAN
genes like me logo Genes that share paralogs with WDR6: view

No data available for Paralogs for WDR6 Gene

Variants for WDR6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR6 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs150300426 Likely Pathogenic: Short stature 49,014,077(+) G/A MISSENSE_VARIANT
rs483352745 Uncertain Significance: not provided 49,013,491(+) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for WDR6 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR6 Gene

Variant ID Type Subtype PubMed ID
nsv954488 CNV deletion 24416366

Variation tolerance for WDR6 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR6 Gene

Human Gene Mutation Database (HGMD)
WDR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR6 Gene

Disorders for WDR6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDR6 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search WDR6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR6

genes like me logo Genes that share disorders with WDR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR6 Gene

Publications for WDR6 Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4 54
  2. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PMID: 17216128) Xie X … Chen Y (Molecular and cellular biochemistry 2007) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PMID: 10903905) Li D … Roberts R (Biochemical and biophysical research communications 2000) 3 4 54

Products for WDR6 Gene

Sources for WDR6 Gene