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Aliases for WDR5B Gene

Aliases for WDR5B Gene

  • WD Repeat Domain 5B 2 3 5

External Ids for WDR5B Gene

Previous GeneCards Identifiers for WDR5B Gene

  • GC03M118854
  • GC03M122081
  • GC03M123412
  • GC03M123453
  • GC03M123452
  • GC03M123613
  • GC03M119504

Summaries for WDR5B Gene

Entrez Gene Summary for WDR5B Gene

  • This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5B Gene

WDR5B (WD Repeat Domain 5B) is a Protein Coding gene. An important paralog of this gene is WDR5.

UniProtKB/Swiss-Prot for WDR5B Gene

  • May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

Additional gene information for WDR5B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5B Gene

Genomics for WDR5B Gene

GeneHancer (GH) Regulatory Elements for WDR5B Gene

Promoters and enhancers for WDR5B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I122414 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 573.3 -0.1 -107 2.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 WDR5B LOC102723582 ENSG00000242531 FAM162A CCDC58
GH03I122513 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.9 -98.4 -98360 2.3 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 KPNA1 LOC105374071 WDR5B LOC102723582 ENSG00000273454 PARP14 GC03P122484
GH03I122381 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18 +32.5 32463 3.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FAM162A CCDC58 WDR5B LOC102723582
GH03I122562 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 -148.4 -148419 3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF143 ZNF263 SP3 DTX3L PARP9 LOC102723582 PARP14 WDR5B KPNA1
GH03I122482 Enhancer 1 Ensembl ENCODE 22.7 -67.1 -67117 1.5 HDGF SMAD1 BATF IRF4 RFX5 GTF3C2 SMARCC2 ATF7 ETV6 FOS GC03P122484 ENSG00000275348 WDR5B LOC102723582 KPNA1 CCDC58 FAM162A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR5B gene promoter:

Genomic Locations for WDR5B Gene

Genomic Locations for WDR5B Gene
chr3:122,411,853-122,416,051
(GRCh38/hg38)
Size:
4,199 bases
Orientation:
Minus strand
chr3:122,130,700-122,134,882
(GRCh37/hg19)

Genomic View for WDR5B Gene

Genes around WDR5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5B Gene

Proteins for WDR5B Gene

  • Protein details for WDR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ2-WDR5B_HUMAN
    Recommended name:
    WD repeat-containing protein 5B
    Protein Accession:
    Q86VZ2
    Secondary Accessions:
    • B2RCM9
    • Q9NUL4

    Protein attributes for WDR5B Gene

    Size:
    330 amino acids
    Molecular mass:
    36338 Da
    Quaternary structure:
    • Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).

neXtProt entry for WDR5B Gene

Post-translational modifications for WDR5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR5B Gene

Domains & Families for WDR5B Gene

Gene Families for WDR5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VZ2

UniProtKB/Swiss-Prot:

WDR5B_HUMAN :
  • Belongs to the WD repeat WDR5/wds family.
Family:
  • Belongs to the WD repeat WDR5/wds family.
genes like me logo Genes that share domains with WDR5B: view

Function for WDR5B Gene

Molecular function for WDR5B Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

Phenotypes From GWAS Catalog for WDR5B Gene

genes like me logo Genes that share phenotypes with WDR5B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5B Gene

Localization for WDR5B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR5B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for WDR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036064 ciliary basal body IBA --
genes like me logo Genes that share ontologies with WDR5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WDR5B Gene

Pathways & Interactions for WDR5B Gene

SuperPathways for WDR5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060271 cilium assembly IBA --
genes like me logo Genes that share ontologies with WDR5B: view

No data available for Pathways by source and SIGNOR curated interactions for WDR5B Gene

Drugs & Compounds for WDR5B Gene

No Compound Related Data Available

Transcripts for WDR5B Gene

mRNA/cDNA for WDR5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR5B Gene

WD repeat domain 5B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5B Gene

No ASD Table

Relevant External Links for WDR5B Gene

GeneLoc Exon Structure for
WDR5B
ECgene alternative splicing isoforms for
WDR5B

Expression for WDR5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR5B Gene

This gene is overexpressed in Tlymphocyte (55.2) and Brain (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR5B Gene



Protein tissue co-expression partners for WDR5B Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR5B Gene:

WDR5B

SOURCE GeneReport for Unigene cluster for WDR5B Gene:

Hs.567513

Evidence on tissue expression from TISSUES for WDR5B Gene

  • Nervous system(4.5)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with WDR5B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR5B Gene

Orthologs for WDR5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR5B 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia WDR5B 33
  • 89.39 (n)
dog
(Canis familiaris)
Mammalia WDR5B 33 34
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia Wdr5b 33
  • 85.16 (n)
mouse
(Mus musculus)
Mammalia Wdr5b 33 16 34
  • 84.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR5B 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR5B 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR5 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR5B 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1646 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12820 33
zebrafish
(Danio rerio)
Actinopterygii wdr5 34
  • 83 (a)
OneToMany
wufk47f04 33
fruit fly
(Drosophila melanogaster)
Insecta wds 35 34
  • 84 (a)
CG10931 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C14B1.4 35
  • 66 (a)
K04G11.4 35
  • 58 (a)
wdr-5.1 34
  • 56 (a)
ManyToMany
ZC302.2 35
  • 52 (a)
wdr-5.2 34
  • 46 (a)
ManyToMany
wdr-5.3 34
  • 34 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02730 33
  • 56.91 (n)
soybean
(Glycine max)
eudicotyledons Gma.3842 33
rice
(Oryza sativa)
Liliopsida Os07g0572000 33
  • 51.92 (n)
Os.25532 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 34
  • 70 (a)
OneToMany
Species where no ortholog for WDR5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5B Gene

ENSEMBL:
Gene Tree for WDR5B (if available)
TreeFam:
Gene Tree for WDR5B (if available)

Paralogs for WDR5B Gene

Paralogs for WDR5B Gene

(16) SIMAP similar genes for WDR5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDR5B: view

Variants for WDR5B Gene

Sequence variations from dbSNP and Humsavar for WDR5B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000041500 -- 122,411,725(-) T/G downstream_transcript_variant
rs1000063567 -- 122,413,227(-) T/G 3_prime_UTR_variant
rs1000742397 -- 122,411,861(-) T/C 3_prime_UTR_variant
rs1000869933 -- 122,417,419(-) A/G upstream_transcript_variant
rs1001174774 -- 122,411,511(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR5B Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV deletion 18451855

Variation tolerance for WDR5B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR5B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5B Gene

Disorders for WDR5B Gene

Additional Disease Information for WDR5B

No disorders were found for WDR5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR5B Gene

Publications for WDR5B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J … Fried M (Human molecular genetics 1999) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M … Krainc D (Human molecular genetics 2012) 3 58

Products for WDR5B Gene

Sources for WDR5B Gene

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