Aliases for WDR59 Gene
External Ids for WDR59 Gene
Previous GeneCards Identifiers for WDR59 Gene
GeneCards Summary for WDR59 Gene
WDR59 (WD Repeat Domain 59) is a Protein Coding gene. Diseases associated with WDR59 include Intermittent Explosive Disorder. Among its related pathways are mTOR signaling pathway (KEGG) and PI3K / Akt Signaling. An important paralog of this gene is GEMIN5.
UniProtKB/Swiss-Prot Summary for WDR59 Gene
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).