Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR54 Gene

Aliases for WDR54 Gene

  • WD Repeat Domain 54 2 3 5

External Ids for WDR54 Gene

Previous GeneCards Identifiers for WDR54 Gene

  • GC02P074561
  • GC02P074502
  • GC02P074648
  • GC02P074385

Summaries for WDR54 Gene

GeneCards Summary for WDR54 Gene

WDR54 (WD Repeat Domain 54) is a Protein Coding gene.

Additional gene information for WDR54 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR54 Gene

Genomics for WDR54 Gene

GeneHancer (GH) Regulatory Elements for WDR54 Gene

Promoters and enhancers for WDR54 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I074420 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +2.5 2450 8.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF207 ZNF143 PAF1 WDR54 ENSG00000272183 LBX2 LBX2-AS1 C2orf81 SLC4A5 DCTN1 ENSG00000159239 PIR40772 GC02M074419
GH02I074421 Enhancer 0.4 Ensembl 550.8 -1.8 -1777 0.2 HDGF ATF2 C2orf81 GC02M074419 PIR40772 WDR54 HMGA1P8 ENSG00000159239
GH02I074196 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.5 -222.9 -222931 3.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ENSG00000279070 MTHFD2 PCGF1 DUSP11 INO80B ENSG00000273245 WBP1 AUP1 TTC31 MOB1A
GH02I074653 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.1 +232.5 232523 1.2 PKNOX1 ATF1 SIN3A GLI4 ZNF2 YY1 SLC30A9 KLF7 FOS ATF7 SEMA4F GC02P074655 DCTN1 WDR54
GH02I074372 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.7 -47.7 -47689 2.5 MEIS2 MXI1 KLF1 ATF1 SIN3A ZFHX2 POLR2A ZNF600 ATF7 CREM GC02M074371 DCTN1 SLC4A5 WDR54 C2orf81 ENSG00000159239 RTKN BOLA3 BOLA3-AS1 ENSG00000272183
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR54 gene promoter:

Genomic Locations for WDR54 Gene

Genomic Locations for WDR54 Gene
chr2:74,421,678-74,425,755
(GRCh38/hg38)
Size:
4,078 bases
Orientation:
Plus strand
chr2:74,648,805-74,652,882
(GRCh37/hg19)

Genomic View for WDR54 Gene

Genes around WDR54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR54 Gene

Proteins for WDR54 Gene

  • Protein details for WDR54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H977-WDR54_HUMAN
    Recommended name:
    WD repeat-containing protein 54
    Protein Accession:
    Q9H977
    Secondary Accessions:
    • D6W5I3
    • Q53H85
    • Q86V45

    Protein attributes for WDR54 Gene

    Size:
    334 amino acids
    Molecular mass:
    35891 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR54 Gene

Post-translational modifications for WDR54 Gene

  • Ubiquitination at isoforms=266 and isoforms=280

Other Protein References for WDR54 Gene

No data available for DME Specific Peptides for WDR54 Gene

Domains & Families for WDR54 Gene

Gene Families for WDR54 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR54: view

No data available for UniProtKB/Swiss-Prot for WDR54 Gene

Function for WDR54 Gene

genes like me logo Genes that share phenotypes with WDR54: view

Animal Model Products

miRNA for WDR54 Gene

miRTarBase miRNAs that target WDR54

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR54 Gene

Localization for WDR54 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR54 gene
Compartment Confidence
mitochondrion 3
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR54 Gene

Pathways & Interactions for WDR54 Gene

SuperPathways for WDR54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR54 Gene

Drugs & Compounds for WDR54 Gene

No Compound Related Data Available

Transcripts for WDR54 Gene

Unigene Clusters for WDR54 Gene

WD repeat domain 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR54 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -
SP12: -
SP13:
SP14: -

ExUns: 10a · 10b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for WDR54 Gene

GeneLoc Exon Structure for
WDR54
ECgene alternative splicing isoforms for
WDR54

Expression for WDR54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR54 Gene

Protein differential expression in normal tissues from HIPED for WDR54 Gene

This gene is overexpressed in Retina (33.2) and Testis (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR54 Gene



Protein tissue co-expression partners for WDR54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR54 Gene:

WDR54

SOURCE GeneReport for Unigene cluster for WDR54 Gene:

Hs.643480

Evidence on tissue expression from TISSUES for WDR54 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with WDR54: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR54 Gene

Orthologs for WDR54 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR54 33 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia WDR54 34 33
  • 88.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDR54 33 34
  • 88.69 (n)
rat
(Rattus norvegicus)
Mammalia Wdr54 33
  • 86.03 (n)
mouse
(Mus musculus)
Mammalia Wdr54 16 34 33
  • 85.73 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR54 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR54 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751597 33
  • 66.16 (n)
WDR54 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR54 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wdr54 33 34
  • 60.24 (n)
worm
(Caenorhabditis elegans)
Secernentea F39H12.2 34
  • 23 (a)
OneToOne
Species where no ortholog for WDR54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WDR54 Gene

ENSEMBL:
Gene Tree for WDR54 (if available)
TreeFam:
Gene Tree for WDR54 (if available)

Paralogs for WDR54 Gene

No data available for Paralogs for WDR54 Gene

Variants for WDR54 Gene

Sequence variations from dbSNP and Humsavar for WDR54 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000899475 -- 74,425,076(+) G/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1002394532 -- 74,425,347(+) C/G intron_variant
rs1002448553 -- 74,425,594(+) G/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1002510898 -- 74,420,131(+) C/A upstream_transcript_variant
rs1002607428 -- 74,421,694(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR54 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
esv3591281 CNV loss 21293372
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for WDR54 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR54 Gene

Disorders for WDR54 Gene

Additional Disease Information for WDR54

No disorders were found for WDR54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR54 Gene

Publications for WDR54 Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for WDR54 Gene

Sources for WDR54 Gene

Content
Loading form....