This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for WDR5 Gene

Aliases for WDR5 Gene

  • WD Repeat Domain 5 2 3 5
  • Cilia And Flagella Associated Protein 89 2 3
  • WD Repeat-Containing Protein 5 3 4
  • BMP2-Induced 3-Kb Gene Protein 3 4
  • CFAP89 2 3
  • SWD3 2 3
  • SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae) 2
  • SWD3, Set1c WD40 Repeat Protein, Homolog 3
  • BIG-3 3
  • WDR5 5
  • BIG3 4

External Ids for WDR5 Gene

Previous GeneCards Identifiers for WDR5 Gene

  • GC09U990098
  • GC03M123454
  • GC03M123451
  • GC09P134030
  • GC09P135991
  • GC09P137001
  • GC09P106494

Summaries for WDR5 Gene

Entrez Gene Summary for WDR5 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5 Gene

WDR5 (WD Repeat Domain 5) is a Protein Coding gene. Diseases associated with WDR5 include Kabuki Syndrome 1 and Kleefstra Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and histone acetyltransferase activity (H4-K8 specific). An important paralog of this gene is WDR5B.

UniProtKB/Swiss-Prot Summary for WDR5 Gene

  • Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Gene Wiki entry for WDR5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR5 Gene

Genomics for WDR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR5

Top Transcription factor binding sites by QIAGEN in the WDR5 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • STAT5A
  • Tal-1beta

Genomic Locations for WDR5 Gene

Latest Assembly
chr9:134,135,199-134,159,968
(GRCh38/hg38)
Size:
24,770 bases
Orientation:
Plus strand

Previous Assembly
chr9:137,000,321-137,025,090
(GRCh37/hg19 by Entrez Gene)
Size:
24,770 bases
Orientation:
Plus strand

chr9:137,000,487-137,025,093
(GRCh37/hg19 by Ensembl)
Size:
24,607 bases
Orientation:
Plus strand

Genomic View for WDR5 Gene

Genes around WDR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5 Gene

Proteins for WDR5 Gene

  • Protein details for WDR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61964-WDR5_HUMAN
    Recommended name:
    WD repeat-containing protein 5
    Protein Accession:
    P61964
    Secondary Accessions:
    • Q91VA5
    • Q9NWX7
    • Q9UGP9

    Protein attributes for WDR5 Gene

    Size:
    334 amino acids
    Molecular mass:
    36588 Da
    Quaternary structure:
    • Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3 (By similarity). Interacts with HCFC1 (PubMed:12670868). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:15199122, PubMed:15960975, PubMed:17021013, PubMed:17500065). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:14992727, PubMed:18378692). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts with KMT2A/MLL1 (via WIN motif) and RBBP5; the interaction is direct (PubMed:19556245, PubMed:21220120, PubMed:22665483, PubMed:22266653, PubMed:18840606, PubMed:18829459). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT2A, MBIP and KAT14 (PubMed:19103755). Interacts with histone H3 (PubMed:16946699, PubMed:16600877, PubMed:16829960, PubMed:16829959). Interacts with SETD1A (via WIN motif) (PubMed:17998332, PubMed:22665483, PubMed:22266653). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338). Interacts with ZNF335 (PubMed:19131338, PubMed:23178126). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338). Interacts with PER1 (By similarity). Interacts with KMT2B (via WIN motif), KMT2C (via WIN motif), KMT2D (via WIN motif) and SETD1B (via WIN motif) (PubMed:22665483, PubMed:22266653, PubMed:18840606).
    SequenceCaution:
    • Sequence=CAB66159.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WDR5 Gene

neXtProt entry for WDR5 Gene

Post-translational modifications for WDR5 Gene

  • Ubiquitination at Lys27, Lys32, and Lys227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR5 Gene

Domains & Families for WDR5 Gene

Protein Domains for WDR5 Gene

Suggested Antigen Peptide Sequences for WDR5 Gene

GenScript: Design optimal peptide antigens:
  • BMP2-induced 3-kb gene protein (WDR5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61964

UniProtKB/Swiss-Prot:

WDR5_HUMAN :
  • Belongs to the WD repeat WDR5/wds family.
Family:
  • Belongs to the WD repeat WDR5/wds family.
genes like me logo Genes that share domains with WDR5: view

Function for WDR5 Gene

Molecular function for WDR5 Gene

UniProtKB/Swiss-Prot Function:
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Phenotypes From GWAS Catalog for WDR5 Gene

Gene Ontology (GO) - Molecular Function for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12670868
GO:0035064 methylated histone binding IDA 16600877
GO:0042393 histone binding IBA 21873635
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
genes like me logo Genes that share ontologies with WDR5: view
genes like me logo Genes that share phenotypes with WDR5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5 Gene

Localization for WDR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus IDA 17500065
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0035097 histone methyltransferase complex IDA 17355966
genes like me logo Genes that share ontologies with WDR5: view

Pathways & Interactions for WDR5 Gene

genes like me logo Genes that share pathways with WDR5: view

Pathways by source for WDR5 Gene

Gene Ontology (GO) - Biological Process for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006325 chromatin organization IEA --
GO:0031175 neuron projection development IEA --
GO:0043687 post-translational protein modification TAS --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with WDR5: view

No data available for SIGNOR curated interactions for WDR5 Gene

Drugs & Compounds for WDR5 Gene

(1) Drugs for WDR5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WDR5 0103 Pharma WD repeat-containing protein 5 (WDR5) antagonist 0

(1) ApexBio Compounds for WDR5 Gene

Compound Action Cas Number
WDR5 0103 WD repeat-containing protein 5 (WDR5) antagonist 890190-22-4
genes like me logo Genes that share compounds with WDR5: view

Drug products for research

Transcripts for WDR5 Gene

mRNA/cDNA for WDR5 Gene

13 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR5

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for WDR5 Gene

GeneLoc Exon Structure for
WDR5

Expression for WDR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for WDR5 Gene

This gene is overexpressed in Fetal gut (6.7) and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR5 Gene



Protein tissue co-expression partners for WDR5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR5

SOURCE GeneReport for Unigene cluster for WDR5 Gene:

Hs.397638

Evidence on tissue expression from TISSUES for WDR5 Gene

  • Lung(4.4)
  • Nervous system(3.6)
  • Skin(2.4)
  • Kidney(2.2)
  • Liver(2.2)
  • Muscle(2.1)
  • Heart(2.1)
  • Intestine(2.1)
  • Blood(2.1)
  • Bone marrow(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with WDR5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR5 Gene

Orthologs for WDR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR5 29 30
  • 99.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 95 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia WDR5 29 30
  • 89.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr5 29
  • 88.32 (n)
Cow
(Bos Taurus)
Mammalia WDR5 29 30
  • 88.02 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wdr5 29 16 30
  • 87.62 (n)
OneToOne
Chicken
(Gallus gallus)
Aves WDR5 29
  • 84.63 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr5 29
  • 80.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii wdr5 29 30
  • 81.84 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012731 29
  • 73.98 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta wds 29 30 31
  • 73.46 (n)
OneToMany
CG10931 31
  • 56 (a)
Worm
(Caenorhabditis elegans)
Secernentea C14B1.4 31
  • 72 (a)
wdr-5.1 29 30
  • 63.09 (n)
ManyToMany
K04G11.4 31
  • 58 (a)
ZC302.2 31
  • 56 (a)
wdr-5.2 30
  • 48 (a)
ManyToMany
wdr-5.3 30
  • 36 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G49660 29
  • 62.24 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0725400 29
  • 61.19 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2859 30
  • 79 (a)
OneToMany
Species where no ortholog for WDR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR5 Gene

ENSEMBL:
Gene Tree for WDR5 (if available)
TreeFam:
Gene Tree for WDR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR5: view image
Alliance of Genome Resources:
Additional Orthologs for WDR5

Paralogs for WDR5 Gene

(19) SIMAP similar genes for WDR5 Gene using alignment to 3 proteins:

  • WDR5_HUMAN
  • V9GYQ5_HUMAN
  • V9GZ59_HUMAN

Pseudogenes.org Pseudogenes for WDR5 Gene

genes like me logo Genes that share paralogs with WDR5: view

Variants for WDR5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs367537994 Not Provided: not provided 134,139,896(+) A/C
NM_017588.3(WDR5):c.19A>C (p.Lys7Gln)
MISSENSE
VAR_081531 -- p.Thr208Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDR5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDR5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv471848 CNV novel sequence insertion 20440878
nsv473682 CNV novel sequence insertion 20440878
nsv475920 CNV novel sequence insertion 20440878
nsv6751 CNV deletion 18451855
nsv825148 CNV gain 20364138

Variation tolerance for WDR5 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR5 Gene

Human Gene Mutation Database (HGMD)
WDR5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR5
Leiden Open Variation Database (LOVD)
WDR5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5 Gene

Disorders for WDR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDR5 Gene - From: COP

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuk1
kleefstra syndrome
  • 9q subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WDR5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WDR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR5 Gene

Publications for WDR5 Gene

  1. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. (PMID: 19556245) Patel A … Cosgrove MS (The Journal of biological chemistry 2009) 3 4 22
  2. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. (PMID: 18829459) Patel A … Cosgrove MS (The Journal of biological chemistry 2008) 3 4 22
  3. Structural basis for molecular recognition and presentation of histone H3 by WDR5. (PMID: 16946699) Schuetz A … Min J (The EMBO journal 2006) 3 4 22
  4. Molecular recognition of histone H3 by the WD40 protein WDR5. (PMID: 16829960) Couture JF … Trievel RC (Nature structural & molecular biology 2006) 3 4 22
  5. The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. (PMID: 22266653) Zhang P … Couture JF (Nucleic acids research 2012) 3 4

Products for WDR5 Gene

Sources for WDR5 Gene