Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR49 Gene

Aliases for WDR49 Gene

  • WD Repeat Domain 49 2 3 5

External Ids for WDR49 Gene

Previous GeneCards Identifiers for WDR49 Gene

  • GC03M168680
  • GC03M167196
  • GC03M164566

Summaries for WDR49 Gene

Entrez Gene Summary for WDR49 Gene

  • This gene encodes a member of the WD repeat protein family with nine WD repeats. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for WDR49 Gene

WDR49 (WD Repeat Domain 49) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB8.

Additional gene information for WDR49 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR49 Gene

Genomics for WDR49 Gene

GeneHancer (GH) Regulatory Elements for WDR49 Gene

Promoters and enhancers for WDR49 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I167652 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 +0.4 421 1.9 SP1 NFIC NFIB POLR2A PRDM1 WDR49 GC03M167593
GH03I167604 Promoter 0.5 EPDnew 550.2 +49.5 49478 0.1 WDR49 GC03M167593
GH03I167683 Enhancer 0.6 UCNEbase 11.6 -30.1 -30106 0.2 CTCF ATF4 WDR49 PDCD10 SERPINI1 ZBBX HMGN1P8 GC03P167665
GH03I167684 Enhancer 0.6 ENCODE 11.6 -30.6 -30605 0.2 CTCF ZNF654 CEBPB CEBPG ATF2 RAD21 ATF4 ATF3 CEBPA ZNF143 SERPINI1 WDR49 PDCD10 ZBBX HMGN1P8 GC03P167665
GH03I167650 Enhancer 0.2 Ensembl 0.8 +3.1 3082 0.6 SERPINI1 WDR49 GC03M167593
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR49 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR49 gene promoter:

Genomic Locations for WDR49 Gene

Genomic Locations for WDR49 Gene
chr3:167,478,684-167,653,983
(GRCh38/hg38)
Size:
175,300 bases
Orientation:
Minus strand
chr3:167,196,472-167,371,771
(GRCh37/hg19)

Genomic View for WDR49 Gene

Genes around WDR49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR49 Gene

Proteins for WDR49 Gene

  • Protein details for WDR49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV35-WDR49_HUMAN
    Recommended name:
    WD repeat-containing protein 49
    Protein Accession:
    Q8IV35
    Secondary Accessions:
    • Q8N297

    Protein attributes for WDR49 Gene

    Size:
    697 amino acids
    Molecular mass:
    79295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR49 Gene

Post-translational modifications for WDR49 Gene

No Post-translational modifications

No data available for DME Specific Peptides for WDR49 Gene

Domains & Families for WDR49 Gene

Gene Families for WDR49 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR49: view

No data available for UniProtKB/Swiss-Prot for WDR49 Gene

Function for WDR49 Gene

Phenotypes From GWAS Catalog for WDR49 Gene

genes like me logo Genes that share phenotypes with WDR49: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR49 Gene

Localization for WDR49 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR49 gene
Compartment Confidence
cytosol 3
peroxisome 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR49 Gene

Pathways & Interactions for WDR49 Gene

SuperPathways for WDR49 Gene

No Data Available

Interacting Proteins for WDR49 Gene

Selected Interacting proteins: Q8IV35-WDR49_HUMAN for WDR49 Gene via IID

Gene Ontology (GO) - Biological Process for WDR49 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR49 Gene

Drugs & Compounds for WDR49 Gene

No Compound Related Data Available

Transcripts for WDR49 Gene

mRNA/cDNA for WDR49 Gene

Unigene Clusters for WDR49 Gene

WD repeat domain 49:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR49 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4: - - - - - - - - -

Relevant External Links for WDR49 Gene

GeneLoc Exon Structure for
WDR49
ECgene alternative splicing isoforms for
WDR49

Expression for WDR49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR49 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR49 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Spinal cord (cervical c-1) (x4.9), and Brain - Caudate (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for WDR49 Gene

This gene is overexpressed in Pancreas (29.9), Peripheral blood mononuclear cells (19.6), and Adipocyte (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR49 Gene



Protein tissue co-expression partners for WDR49 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR49 Gene:

WDR49

SOURCE GeneReport for Unigene cluster for WDR49 Gene:

Hs.213762
genes like me logo Genes that share expression patterns with WDR49: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR49 Gene

Orthologs for WDR49 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR49 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia WDR49 33 34
  • 86.9 (n)
mouse
(Mus musculus)
Mammalia Wdr49 33 16 34
  • 82.23 (n)
rat
(Rattus norvegicus)
Mammalia Wdr49 33
  • 81.82 (n)
cow
(Bos Taurus)
Mammalia WDR49 34
  • 71 (a)
OneToOne
MGC151671 33
oppossum
(Monodelphis domestica)
Mammalia WDR49 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR49 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR49 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr49 33
  • 63.38 (n)
Str.13668 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-202c14.3 34
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40583 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
OneToMany
Species where no ortholog for WDR49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR49 Gene

ENSEMBL:
Gene Tree for WDR49 (if available)
TreeFam:
Gene Tree for WDR49 (if available)

Paralogs for WDR49 Gene

Paralogs for WDR49 Gene

Pseudogenes.org Pseudogenes for WDR49 Gene

genes like me logo Genes that share paralogs with WDR49: view

Variants for WDR49 Gene

Sequence variations from dbSNP and Humsavar for WDR49 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs193921101 uncertain-significance, Malignant tumor of prostate 167,527,959(-) G/T coding_sequence_variant, stop_gained
rs74903439 A colorectal cancer sample 167,604,375(-) C/G/T coding_sequence_variant, missense_variant
rs1000025944 -- 167,492,938(-) G/A intron_variant
rs1000047162 -- 167,548,856(-) C/A intron_variant
rs1000059337 -- 167,586,676(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR49 Gene

Variant ID Type Subtype PubMed ID
dgv8727n54 CNV loss 21841781
esv26146 CNV loss 19812545
esv3432110 CNV insertion 20981092
esv3598566 CNV loss 21293372
nsv592495 CNV gain 21841781
nsv592497 CNV loss 21841781

Variation tolerance for WDR49 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR49 Gene

Disorders for WDR49 Gene

Additional Disease Information for WDR49

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR49 Gene

Publications for WDR49 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for WDR49 Gene

Sources for WDR49 Gene

Content
Loading form....