The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016] See more...

Aliases for WDR48 Gene

Aliases for WDR48 Gene

  • WD Repeat Domain 48 2 3 5
  • P80 2 3 4
  • WD Repeat-Containing Protein 48 3 4
  • WD Repeat Endosomal Protein 3 4
  • KIAA1449 2 4
  • Bun62 2 3
  • SPG60 2 3
  • UAF1 3 4
  • Testicular Tissue Protein Li 224 3
  • USP1 Associated Factor 1 3
  • USP1-Associated Factor 1 4
  • WDR48 5

External Ids for WDR48 Gene

Previous GeneCards Identifiers for WDR48 Gene

  • GC03P039069
  • GC03P039093

Summaries for WDR48 Gene

Entrez Gene Summary for WDR48 Gene

  • The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]

GeneCards Summary for WDR48 Gene

WDR48 (WD Repeat Domain 48) is a Protein Coding gene. Diseases associated with WDR48 include Autosomal Recessive Spastic Paraplegia Type 60 and Hereditary Spastic Paraplegia. Among its related pathways are Deubiquitination and Metabolism of proteins.

UniProtKB/Swiss-Prot Summary for WDR48 Gene

  • Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107).
  • (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR48 Gene

Genomics for WDR48 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR48 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR48 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR48

Top Transcription factor binding sites by QIAGEN in the WDR48 gene promoter:
  • Arnt
  • ATF
  • ATF-2
  • c-Jun
  • CRE-BP1
  • GR-alpha
  • GR-beta
  • Pax-2
  • Pax-2a

Genomic Locations for WDR48 Gene

Latest Assembly
chr3:39,052,002-39,096,671
(GRCh38/hg38)
Size:
44,670 bases
Orientation:
Plus strand

Previous Assembly
chr3:39,093,507-39,138,155
(GRCh37/hg19 by Entrez Gene)
Size:
44,649 bases
Orientation:
Plus strand

chr3:39,093,489-39,138,155
(GRCh37/hg19 by Ensembl)
Size:
44,667 bases
Orientation:
Plus strand

Genomic View for WDR48 Gene

Genes around WDR48 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR48 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR48 Gene

Proteins for WDR48 Gene

  • Protein details for WDR48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAF3-WDR48_HUMAN
    Recommended name:
    WD repeat-containing protein 48
    Protein Accession:
    Q8TAF3
    Secondary Accessions:
    • B4DM86
    • B4DQI2
    • B4DY84
    • Q63HJ2
    • Q658Y1
    • Q8N3Z1
    • Q9NSK8
    • Q9P279

    Protein attributes for WDR48 Gene

    Size:
    677 amino acids
    Molecular mass:
    76210 Da
    Quaternary structure:
    • Interacts with USP46 (PubMed:19075014, PubMed:26388029). Interacts with USP1 (PubMed:18082604, PubMed:26388029). Interacts with USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Component of the USP12-WDR20-WDR48 deubiquitinating complex (PubMed:27373336). Interacts with PHLPP1 (PubMed:24145035). Interacts with RAD51AP1; the interaction is direct and promotes formation of a trimeric complex with RAD51 via RAD51AP1 (PubMed:27463890, PubMed:27239033).
    • (Microbial infection) Interacts with papillomavirus HPV11 E1 protein.
    • (Microbial infection) Interacts with Saimiriine herpesvirus TIP protein.
    SequenceCaution:
    • Sequence=AAH37168.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA95973.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH56182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH56300.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Knockdown of WDR48 increases Akt activation.

    Three dimensional structures from OCA and Proteopedia for WDR48 Gene

    Alternative splice isoforms for WDR48 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR48 Gene

Post-translational modifications for WDR48 Gene

  • Ubiquitination at Lys578, Lys106, and Lys327
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Boster Bio Antibodies for WDR48
  • Santa Cruz Biotechnology (SCBT) Antibodies for WDR48

No data available for DME Specific Peptides for WDR48 Gene

Domains & Families for WDR48 Gene

Gene Families for WDR48 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR48 Gene

GenScript: Design optimal peptide antigens:
  • p80 (WDR48_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAF3

UniProtKB/Swiss-Prot:

WDR48_HUMAN :
  • N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization (Probable). The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.
  • Belongs to the WD repeat WDR48 family.
Domain:
  • N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization (Probable). The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.
Family:
  • Belongs to the WD repeat WDR48 family.
genes like me logo Genes that share domains with WDR48: view

Function for WDR48 Gene

Molecular function for WDR48 Gene

UniProtKB/Swiss-Prot Function:
Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488).

Phenotypes From GWAS Catalog for WDR48 Gene

Gene Ontology (GO) - Molecular Function for WDR48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 31253762
GO:0003690 double-stranded DNA binding IDA 27239033
GO:0003697 single-stranded DNA binding IDA 27239033
GO:0005515 protein binding IEA,IPI 18082604
GO:0043130 ubiquitin binding IBA 21873635
genes like me logo Genes that share ontologies with WDR48: view
genes like me logo Genes that share phenotypes with WDR48: view

Human Phenotype Ontology for WDR48 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for WDR48 Gene

miRTarBase miRNAs that target WDR48

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR48

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR48 Gene

Localization for WDR48 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR48 Gene

Nucleus. Cytoplasm. Lysosome. Late endosome. Note=Mainly in cytoplasmic compartments (PubMed:12196293, PubMed:18032488). In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11 (PubMed:18032488). {ECO:0000269 PubMed:12196293, ECO:0000269 PubMed:18032488}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR48 gene
Compartment Confidence
nucleus 5
lysosome 4
endosome 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18082604
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with WDR48: view

Pathways & Interactions for WDR48 Gene

genes like me logo Genes that share pathways with WDR48: view

Pathways by source for WDR48 Gene

SIGNOR curated interactions for WDR48 Gene

Activates:

Gene Ontology (GO) - Biological Process for WDR48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA,IDA 27239033
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with WDR48: view

Drugs & Compounds for WDR48 Gene

No Compound Related Data Available

Transcripts for WDR48 Gene

mRNA/cDNA for WDR48 Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR48

Alternative Splicing Database (ASD) splice patterns (SP) for WDR48 Gene

No ASD Table

Relevant External Links for WDR48 Gene

GeneLoc Exon Structure for
WDR48

Expression for WDR48 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR48 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR48 Gene

This gene is overexpressed in Breast (21.1) and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR48 Gene



Protein tissue co-expression partners for WDR48 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR48

SOURCE GeneReport for Unigene cluster for WDR48 Gene:

Hs.109778

mRNA Expression by UniProt/SwissProt for WDR48 Gene:

Q8TAF3-WDR48_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR48 Gene

  • Nervous system(5)
  • Liver(4.3)
  • Stomach(4.3)
  • Eye(4.2)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with WDR48: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR48 Gene

Orthologs for WDR48 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR48 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR48 29 30
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR48 29 30
  • 95.08 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR48 30
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR48 30
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR48 29 30
  • 93.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr48 29
  • 88.91 (n)
Mouse
(Mus musculus)
Mammalia Wdr48 29 16 30
  • 88.56 (n)
OneToOne
Chicken
(Gallus gallus)
Aves WDR48 29 30
  • 86.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR48 30
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr48 29
  • 81.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33731 29
Zebrafish
(Danio rerio)
Actinopterygii WDR48 (3 of 3) 30
  • 91 (a)
OneToMany
WDR48 (2 of 3) 30
  • 90 (a)
OneToMany
wdr48 29 30
  • 77.6 (n)
OneToMany
wufd19a04 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001361 29
  • 58.05 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG9062 29 30
  • 57.6 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F35G12.4 29
  • 55.04 (n)
wdr-48 30
  • 45 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAF4 30
  • 16 (a)
OneToMany
MDV1 30
  • 13 (a)
OneToMany
DUF1 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LRS1 29
  • 49.64 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0165000 29
  • 49.72 (n)
Species where no ortholog for WDR48 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR48 Gene

ENSEMBL:
Gene Tree for WDR48 (if available)
TreeFam:
Gene Tree for WDR48 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR48: view image
Alliance of Genome Resources:
Additional Orthologs for WDR48

Paralogs for WDR48 Gene

(9) SIMAP similar genes for WDR48 Gene using alignment to 8 proteins:

  • WDR48_HUMAN
  • C9JC24_HUMAN
  • C9JQ19_HUMAN
  • F8W6P2_HUMAN
  • F8W7Q3_HUMAN
  • F8W7Y5_HUMAN
  • F8W9K4_HUMAN
  • L8EA86_HUMAN
genes like me logo Genes that share paralogs with WDR48: view

No data available for Paralogs for WDR48 Gene

Variants for WDR48 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR48 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs148407227 Uncertain Significance: Hereditary spastic paraplegia; not provided 39,066,559(+) T/G
NM_020839.4(WDR48):c.280T>G (p.Ser94Ala)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs35965777 Benign: not provided 39,063,106(+) T/C
NM_020839.4(WDR48):c.105T>C (p.Ala35=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDR48 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDR48 Gene

Variant ID Type Subtype PubMed ID
esv2759141 CNV loss 17122850
nsv1007100 CNV loss 25217958

Variation tolerance for WDR48 Gene

Residual Variation Intolerance Score: 7.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR48 Gene

Human Gene Mutation Database (HGMD)
WDR48
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR48
Leiden Open Variation Database (LOVD)
WDR48

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR48 Gene

Disorders for WDR48 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WDR48 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
autosomal recessive spastic paraplegia type 60
  • spg60
hereditary spastic paraplegia
  • familial spastic paraplegia
interstitial nephritis, karyomegalic
  • kmin
motor neuron disease
  • motor neuron diseases
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search WDR48 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR48

genes like me logo Genes that share disorders with WDR48: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR48 Gene

Publications for WDR48 Gene

  1. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G … Gleeson JG (Science (New York, N.Y.) 2014) 3 4 72
  2. Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes. (PMID: 18032488) Côté-Martin A … Archambault J (Journal of virology 2008) 3 4 22
  3. Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. (PMID: 12196293) Park J … Jung JU (Immunity 2002) 2 3 4
  4. The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. (PMID: 32350107) Liang F … Kupfer GM (The Journal of biological chemistry 2020) 3 4
  5. The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation. (PMID: 32587090) Hodul M … Juo P (The Journal of biological chemistry 2020) 2 3

Products for WDR48 Gene

Sources for WDR48 Gene